Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kamalakannan Vishnu"'
Autor:
Jessica L. Childs-Disney, Alicia J. Angelbello, Matthew D. Disney, Sarah Wagner-Griffin, Raphael I. Benhamou, Jonathan L. Chen, Kamalakannan Vishnu, Masahito Abe
Publikováno v:
J Med Chem
Myotonic dystrophy type 2 (DM2) is one of >40 microsatellite disorders caused by RNA repeat expansions. The DM2 repeat expansion, r(CCUG)(exp) (where “exp” denotes expanded repeating nucleotides), is harbored in intron 1 of the CCHC-type zinc fin
Autor:
Alexander Adibekian, Jessica L. Childs-Disney, Jie Zhang, Hye Jin Park, Matthew D. Disney, M. Maral Mouradian, Kamalakannan Vishnu, Ryan J. Andrews, Peiyuan Zhang, Matthew G. Costales, Sai Pradeep Velagapudi, Daniel Abegg, Eunsung Junn, Walter N. Moss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Parkinson’s disease and its associated dementia can be caused by elevated levels of α-synuclein protein. Despite many efforts, however, targeting α-synuclein at the protein level has been challenging. In this manuscript, we describe
Publikováno v:
Cell chemical biology. 26(8)
Summary Small-molecule targeted recruitment of nucleases to RNA is a powerful method to affect RNA biology. Inforna, a sequence-based design approach to target RNA, enables the design of small molecules that bind to and cleave RNA in a selective and