Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kamala, Pant"'
Publikováno v:
Environmental and Molecular Mutagenesis. 59:785-797
Splenic tumors have been reported in rat cancer bioassays with para-chloroaniline (PCA) and aniline. Development of these tumors is hypothesized to be due to hematotoxicity via the formation of methemoglobin (MetHb) and not direct DNA reactivity. To
Publikováno v:
Environmental and Molecular Mutagenesis. 58:190-198
In vitro cell transformation assays (CTA) are used to assess the carcinogenic potential of chemicals and complex mixtures and can detect nongenotoxic as well as genotoxic carcinogens. The Bhas 42 CTA has been developed with both initiation and promot
Autor:
Michelle O. Kenyon, Patricia A. Escobar, Rohan Kulkarni, Melisa Masuda-Herrera, Aparajita Dutta, Megan Young, M. Vijayaraj Reddy, Joel P. Bercu, Robert A. Jolly, Caren Brown, Shannon W. Bruce, Julia Kenny, Kamala Pant, Krista L. Dobo, Marie McKeon, Alejandra Trejo-Martin, Sheila M. Galloway
Publikováno v:
Environmental and molecular mutagenesisREFERENCES. 60(9)
Arylboronic acids and esters (referred to collectively as arylboronic compounds) are commonly used intermediates in the synthesis of pharmaceuticals but pose a challenge for chemical syntheses because they are often positive for bacterial mutagenicit
Autor:
Kamala Pant, Emily Dakoulas, Valentine O. Wagner, Rohan Kulkarni, Shannon W. Bruce, Edgar Andrus, Nicola J. Hewitt, Sandra Springer, Michelle Klug Laforce, Jamie E. Sly, Mark Cecil
Publikováno v:
Environmental and Molecular Mutagenesis. 57:483-496
Bacterial mutation assays are conducted routinely as part of the safety assessment of new chemicals. The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay, required for regulatory submissions. Higher throughput
Autor:
Jessica C Pickles, Andrew D. Scott, Lisa A. Mcginty, Hemad Yasaei, Terry Roberts, Robert F. Newbold, Kamala Pant
Publikováno v:
Mutation Research. Genetic Toxicology and Environmental Mutagenesis
Highlights • Mechanistic evaluation of SHE CTA, specific to B(a)P. • Applicability of the Syrian hamster as a relevant model of carcinogenesis. • Molecular analysis of immortal lines derived from benzo(a)pyrene-induced MT clones. • Morphologi
Publikováno v:
Environmental and Molecular Mutagenesis. 57:220-228
Cigarette smoking remains a major health risk worldwide. Development of newer tobacco products requires the use of quantitative toxicological assays. Recently, v-Ha-ras transfected BALB/c3T3 (Bhas 42) cell transformation assay was established that si
Autor:
John Nicolette, Alison Kondratiuk, G. Jayakumar, Paul Sonders, Meredith Crosby, A. Patel, Emily Dakoulas, Joel Murray, Kamala Pant, R. Vicente, K. Datta, M. Mathur, Rohan Kulkarni, Kyle L. Kolaja
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 100
The bacterial reverse mutation assay (Ames) is a fundamental genetic toxicology test, and efforts to miniaturize the regulatory GLP version are essential in assessing genotoxic liabilities earlier in the drug development pipeline. Two versions of the
Publikováno v:
Environmental and molecular mutagenesis. 59(9)
Splenic tumors have been reported in rat cancer bioassays with para-chloroaniline (PCA) and aniline. Development of these tumors is hypothesized to be due to hematotoxicity via the formation of methemoglobin (MetHb) and not direct DNA reactivity. To
Combination comet/micronucleus assay validation performed by BioReliance under the JaCVAM initiative
Autor:
Jamie E. Sly, Michelle L. Klug La Force, Shannon W. Bruce, Marilyn J. Aardema, Samuel Atta-Safoh, Ljubica Krsmanovic, Sandra Springer, Mirna Arevalo, Fekadu Debelie, Tawney Kelley, Madhav Paranjpe, Timothy Lawlor, Kamala Pant
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :87-97
In the international validation study of the in vivo rat alkaline comet assay (comet assay), the Japanese Center for the Validation of Alternative Methods (JaCVAM) provided three coded chemicals to BioReliance, 1,3-dichloropropene, ethionamide and bu
Autor:
Kimberly Pendino, Kamala Pant, Shannon W. Bruce, Nicholas M. Roden, Craig Wood, Charles Zhang
Publikováno v:
Environmental and Molecular Mutagenesis. 56:777-787
14-Hydroxycodeinone (14-HC) is an α,β-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert for genotoxicity. 14-HC was tested in a combined Modified and Standard Comet Assay to determine if the slight decrease in