Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kamal U. Saikh"'
Autor:
Kamal U Saikh, Cyra M Ranji
Publikováno v:
Viral Immunology. 34:646-652
Host exposure to pathogens engage multiple pathogen recognition receptors (PRRs) including toll-like receptors (TLRs); recruit intracellular signaling adaptor proteins primarily myeloid differentiation primary response protein 88 (MyD88) for activati
Autor:
Kamal U Saikh
Publikováno v:
Immunologic Research
Abstract The continuous emergence of infectious pathogens along with antimicrobial resistance creates a need for an alternative approach to treat infectious diseases. Targeting host factor(s) which are critically involved in immune signaling pathways
Publikováno v:
Journal of Medical Microbiology
Introduction. Melioidosis, caused by Burkholderia pseudomallei , in endemic areas, poses a challenge for treating the diseased populations without accurate diagnosis, and the disease-specific biomarkers linked with the infection have yet to be report
Autor:
Teri L Kissner, Gordon Ruthel, Shahabuddin Alam, Enrique Mann, Dariush Ajami, Mitra Rebek, Eileen Larkin, Stefan Fernandez, Robert G Ulrich, Sun Ping, David S Waugh, Julius Rebek, Kamal U Saikh
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40773 (2012)
Staphylococcal enterotoxin B (SEB) exposure triggers an exaggerated pro-inflammatory cytokine response that often leads to toxic shock syndrome (TSS) associated with organ failure and death. MyD88 mediates pro-inflammatory cytokine signaling induced
Externí odkaz:
https://doaj.org/article/50b5c0b07b3e4f4ea5ee96de78fc9670
Publikováno v:
Immunity, Inflammation and Disease
Introduction Burkholderia mallei (B. mallei) and Burkholderia pseudomallei (B. pseudomallei), causative agents of glanders and melioidosis, respectively, are invasive intracellular pathogens that actively multiply in phagocytic and non-phagocytic cel
Autor:
Teri L Kissner, Gordon Ruthel, Shahabuddin Alam, Robert G Ulrich, Stefan Fernandez, Kamal U Saikh
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15985 (2011)
Ligands binding to Toll-like receptor (TLR), interleukin 1 receptor (IL-1R), or IFN-γR1 are known to trigger MyD88-mediated signaling, which activates pro-inflammatory cytokine responses. Recently we reported that staphylococcal enterotoxins (SEA or
Externí odkaz:
https://doaj.org/article/8baea8e7d62248f19ac86678eb572f62
Autor:
Kamal U. Saikh, Tiffany M. Mott
Publikováno v:
Current Opinion in Infectious Diseases
Purpose of review Burkholderia mallei is a facultative intracellular pathogen that causes the highly contagious and often the fatal disease, glanders. With its high rate of infectivity via aerosol and recalcitrance toward antibiotics, this pathogen i
Autor:
David M. Waag, Kamal U. Saikh, Kei Amemiya, Robert C. Bernhards, Robert G. Ulrich, Shahabuddin Alam
Publikováno v:
Microbial Pathogenesis. 78:20-28
Burkholderia pseudomallei infection causes melioidosis and is often characterized by severe sepsis. Although rare in humans, Burkholderia mallei has caused infections in laboratory workers, and the early innate cellular response to B. mallei in human
Publikováno v:
Proceedings of 3rd International Electronic Conference on Medicinal Chemistry.
Autor:
Martha Hale, Dariush Ajami, Melissa Degardin, Daniel Angus Ryan, Mitra Rebek, Michael D. Cameron, Julius Rebek, Kamal U. Saikh, Shahabuddin Alam, Teri L. Kissner
Publikováno v:
Chemical biologydrug design. 90(6)
Small molecules were developed to attenuate proinflammatory cytokines resulting from activation of MyD88-mediated toll-like receptor (TLR) signaling by Francisella tularensis. Fifty-three tripeptide derivatives were synthesized to mimic a key BB-loop