Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kamal Thapar"'
Publikováno v:
Endocrine pathology. 4(1)
Publikováno v:
Operative Techniques in Neurosurgery. 5:226-230
The transsphenoidal approach has undergone several advancements since its introduction at the beginning of the 20 th century. The operative microscope illuminated and magnified the once dark and narrow corridor and intraoperative videofluoroscopy ass
Publikováno v:
Operative Techniques in Neurosurgery. 5:200-209
For the last 30 years, the transsphenoidal approach has been the principal corridor for the treatment of pituitary tumors. However, transsphenoidal surgery did not reach this position in isolation. Significant contributions in the field of endocrinol
Publikováno v:
Neurosurgery. 51:435-444
THE TRANSSPHENOIDAL APPROACH for sellar tumors has evolved significantly since it was described initially during the first decade of the 20th century. The approach currently incorporates technological advancements and refinements in patient selection
Publikováno v:
Journal of Neuro-Oncology. 54:129-137
Soon after the initial description of acromegaly in the late 19th century, neurosurgeons performed the first operative procedures for the disease. Transcranial procedures eventually yielded to the transsphenoidal approach. Reasonably effective medica
Publikováno v:
Endocrine Pathology. 11:41-48
Octreotide, a somatostatin analog used to treat acromegalic patients harboring a pituitary tumor, acts via somatostatin subtype 2 receptor (SSTR2) and causes significant decrease of circulating GH levels and sometimes mild to moderate tumor shrinkage
Publikováno v:
Hormone Research in Paediatrics. 53:71-75
Active acromegaly is almost always the result of a benign growth hormone (GH)-secreting adenoma of the pituitary gland. Because the same pituitary stem cell can produce both GH and prolactin (PRL), many acromegalic patients also have hyperprolactinem
Publikováno v:
Transgenic Research. 8:191-202
PEPCK/bGH transgenic mice have very high blood levels of foreign GH, and prominent reproductive disturbances, especially in females. To obtain a deeper insight into the causes of these abnormalities, pituitaries of PEPCK/bGH transgenics were studied
Autor:
Kamal Thapar, Lucia Stefaneanu, Bernd W. Scheithauer, Edward R. Laws, Joseph Li, Eva Horvath, Kalman Kovacs, Ricardo V. Lloyd
Publikováno v:
Mayo Clinic Proceedings. 72:893-900
Objective To determine and quantify the in vivo effects of octreotide on the cell cycle kinetics of growth hormone-producing pituitary adenomas. Design A multicenter randomized trial had been conducted to assess the clinical efficacy of octreotide, a
Publikováno v:
Neurosurgery. :765-771
Although most pituitary tumors are well differentiated, histologically benign neoplasms, their clinical behavior is known to vary greatly. These lesions are relentlessly aggressive in some instances yet biologically indolent in others, but these prog