Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kamal R. Abdul Azeez"'
Autor:
Kamal R. Abdul Azeez, Sneha Chatterjee, Channing Yu, Todd R. Golub, Frank Sobott, Jonathan M. Elkins
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The inner centromere protein (INCENP) activates Aurora kinase B (AURKB) and Aurora kinase C. Here the authors provide insights into the activation mechanism of AURKB/C by determining the crystal structure of fully active phosphorylated human AURKC bo
Externí odkaz:
https://doaj.org/article/62e11b721bf345adba1dccc00528f587
Autor:
Stephanie Oerum, N.A. Burgess-Brown, Kamal R. Abdul Azeez, Petra Born, Oktawia Borkowska, Rod Chalk, Opher Gileadi
The electrospray mass/charge distribution for a protein is an instantaneous measurement of surface areas during the transition from liquid to gas phase. Protonation is dependent upon surface area and surface area is related to protein folding under a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0de56052240425598c5a5b2081307b
https://doi.org/10.1101/571091
https://doi.org/10.1101/571091
Autor:
Kamal R. Abdul Azeez, Monika Beerbaum, Dermot M.F. Cooper, Adeeb El-Dahshan, Christian Schillinger, Stefan Knapp, Gesa Schäfer, Gerd Krause, Jörg Rademann, Jonathan M. Elkins, Frank Götz, Marie C. Moutty, Nanako Masada, Andreas Oder, Sylvia Niquet, Annika Kreuchwig, Brigitte Schlegel, Peter Schmieder, Enno Klussmann, Kerstin Zühlke, Walter Rosenthal, Jelena Milic, Jens Peter von Kries
Publikováno v:
Angewandte Chemie. 125:12409-12413
Autor:
Stefan Knapp, Benjamin E. Turk, Finn Wolfreys, Rebecca Konietzny, Kamal R. Abdul Azeez, Gisela Schnapp, Eidarus Salah, Paul Brennan, Hua Jane Lou, Roman Fischer, Alexander Pautsch, Cynthia Tallant, S. Mathea, Benedikt M. Kessler
The mixed lineage kinase ZAK is a key regulator of the MAPK pathway mediating cell survival and inflammatory response. ZAK is targeted by several clinically approved kinase inhibitors, and inhibition of ZAK has been reported to protect from doxorubic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f9cd267c039dfcf7b4320b315ee5e9
https://europepmc.org/articles/PMC5518171/
https://europepmc.org/articles/PMC5518171/
Autor:
David H. Drewry, Eidarus Salah, Joel Morris, John P. Overington, Jowita Mikolajczyk, Francis Atkinson, Alexander Tropsha, Karen Lackey, Jonathan M. Elkins, Kamal R. Abdul Azeez, Mark Kunkel, Nikolai Sepetov, Daniel J. Price, Xi Ping Huang, Eric C. Polley, Timothy M. Willson, Beverly A. Teicher, Vita Fedele, Susanne Müller, Ayman Al Haj Zen, William J. Zuercher, Eugene N. Muratov, Sergei Romanov, Paul Bamborough, Bryan L. Roth, Stefan Knapp, Denis Fourches, M. Szklarz
Despite the success of protein kinase inhibitors as approved therapeutics, drug discovery has focused on a small subset of kinase targets. Here we provide a thorough characterization of the Published Kinase Inhibitor Set (PKIS), a set of 367 small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3b54fff9b892e25076832396fb828f
Autor:
Jonathan M. Elkins, Sunila Pradeep, Anil K. Sood, Nathanael S. Gray, Stefan Knapp, Gabriel Lopez-Berestein, Leticia Campo, Robert C. Bast, Cristian Rodriguez-Aguayo, Fabrizio Miranda, Mohammad KaramiNejadRanjbar, Ashwag Albukhari, Sunanda Dhar, Benedikt M. Kessler, Shujuan Liu, Lingegowda S. Mangala, Serena Bivona, Donatien Fotso Chedom, Clara Redondo, Takeshi Motohara, Roman Fischer, Christopher Yau, Charlotte Taylor, Eidarus Salah, Hideyuki Saya, Hwan Geun Choi, Yiyan Zheng, David Mannion, Ruoyan Xu, Dahai Jiang, Sandra Herrero-Gonzalez, Ahmed Ashour Ahmed, Daniel Klotz, Kamal R. Abdul Azeez, Kevin A. Myers
Publikováno v:
Cancer cell. 30(2)
The adipocyte-rich microenvironment forms a niche for ovarian cancer metastasis, but the mechanisms driving this process are incompletely understood. Here we show that salt-inducible kinase 2 (SIK2) is overexpressed in adipocyte-rich metastatic depos
Autor:
Katharina Schrade, Jessica Tröger, Adeeb Eldahshan, Kerstin Zühlke, Kamal R Abdul Azeez, Jonathan M Elkins, Martin Neuenschwander, Andreas Oder, Mohamed Elkewedi, Sarah Jaksch, Karsten Andrae, Jinliang Li, Joao Fernandes, Paul Markus Müller, Stephan Grunwald, Stephen F Marino, Tanja Vukićević, Jenny Eichhorst, Burkhard Wiesner, Marcus Weber, Michael Kapiloff, Oliver Rocks, Oliver Daumke, Thomas Wieland, Stefan Knapp, Jens Peter von Kries, Enno Klussmann
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191423 (2018)
Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane
Externí odkaz:
https://doaj.org/article/90f46ed5dd9245e28b25eb7c6c87fe03