Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kamal P. Sajwan"'
Autor:
Maksymilian Chruszcz, Jeffrey Schneider, Jeffrey A. Toretsky, Kamal P. Sajwan, Sergey Chasovskikh, Aykut Üren, John L. Casey, Brittany L. Griffin, Radhakrishnan Padmanabhan, Sarah E. Youbi, Abraham Kallarakal, Garrett T. Graham, Hayriye V. Erkizan
Publikováno v:
Nucleic Acids Research
RNA helicases impact RNA structure and metabolism from transcription through translation, in part through protein interactions with transcription factors. However, there is limited knowledge on the role of transcription factor influence upon helicase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22de2fe355a7807b682be76072bdb48
https://doi.org/10.1093/nar/gku1328
https://doi.org/10.1093/nar/gku1328
Autor:
Kamal P. Sajwan, Lauren J. Scher, Aykut Üren, S. Ellen Gamble, Hayriye V. Erkizan, Jeffrey A. Toretsky, Julie S. Barber-Rotenberg
Publikováno v:
Cell Cycle. 10:3397-3408
Ewing tumor is driven by the oncogenic EWS-FLI1 fusion protein that functions as an aberrant transcription factor. The identification of EWS-FLI1 protein partners is essential to enhance its vulnerability as a therapeutic target. We utilized phage di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3eb396f1981ee52f506376e63f605e
https://doi.org/10.4161/cc.10.19.17734
https://doi.org/10.4161/cc.10.19.17734
Autor:
Said Rahim, Aykut Üren, Haydar Çelik, Kamal P. Sajwan, Jenny Han, Hayriye V. Erkizan, Saravana P. Selvanathan, Tsion Z. Minas, Yasemin Saygideger Kont, Benjamin J. Marsh, Jeffrey A. Toretsky, Amrita V. Pai
Publikováno v:
Molecular and cellular biology. 35(18)
Ezrin is a key regulator of cancer metastasis that links the extracellular matrix to the actin cytoskeleton and regulates cell morphology and motility. We discovered a small-molecule inhibitor, NSC305787, that directly binds to ezrin and inhibits its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fb480738109add618b4543287bd6c2
https://pubmed.ncbi.nlm.nih.gov/26149384
https://pubmed.ncbi.nlm.nih.gov/26149384
Autor:
Kamal P. Sajwan, Ellen Gamble, Aykut Üren, Julie S. Barber-Rotenberg, Hayriye V. Erkizan, Lauren M Jacobwitz‐Scher, Jeffrey A. Toretsky
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca7b336b76b240ef06a4be08d9864132
https://doi.org/10.1096/fasebj.25.1_supplement.lb112
https://doi.org/10.1096/fasebj.25.1_supplement.lb112
Autor:
Jeffrey A. Toretsky, Kamal P. Sajwan, Lymor Ringer, Metin Ozdemirli, Olga Rodriguez, Tobey J. MacDonald, Gülay Bulut, Michael D. Hall, Daniel Peaceman, Chris Albanese, Aykut Üren, Elspeth M. Beauchamp, Yichien Lee
The Hedgehog (Hh) pathway is activated in some human cancers, including medulloblastoma. The glioma-associated oncogene homolog (GLI) transcription factors are critical mediators of the activated Hh pathway, and their expression may be elevated in so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744f3a35b05ca7f0b3b26f1c2a7ac904
https://europepmc.org/articles/PMC3007144/
https://europepmc.org/articles/PMC3007144/
Publikováno v:
Analytical biochemistry. 400(2)
Protein purification is still very empirical, and a unified method for purifying proteins without an affinity tag is not available yet. In the postgenomic era, functional genomics, however, strongly demands such a method. In this paper we have formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b60b00202d29cc5e31012d288ed1a33
https://pubmed.ncbi.nlm.nih.gov/20109435
https://pubmed.ncbi.nlm.nih.gov/20109435
Autor:
Kamal P. Sajwan, Aykut Üren, Jenny J. Han, Haydar Çelik, Ben J. Marsh, Amrita V. Pai, Said Rahim, Yasemin Saygideger Kont, Jeffrey A. Toretsky, Tsion Z. Minas
Publikováno v:
Cancer Research. 75:3269-3269
Ezrin is a member of the ezrin-radixin-moesin (ERM) family of actin-membrane linker proteins that play key roles in regulating cell shape, movement, adhesion and signal transduction pathways. The expression of ezrin is linked to the metastatic progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1247c309a2dd7e48a1d031f8ab01f0
https://doi.org/10.1158/1538-7445.am2015-3269
https://doi.org/10.1158/1538-7445.am2015-3269
Autor:
Jeffrey A. Toretsky, Sarah E. Gamble, Kamal P. Sajwan, Radhakrishnan Padmanabhan, Aykut Üren, Hayriye V. Erkizan, Jeffrey Schneider, Wladek Minor, Maksymilian Chruszcz
Publikováno v:
Cancer Research. 73:2747-2747
Background: EWS-FLI1 requires the protein binding of RNA Helicase A (RHA) to enable oncogenic transformation. RHA is a DExH box RNA helicase family member. RHA has critical roles modulating transcription, splicing and translation. RHA also functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d43183220c4d7f67c70d3c637206a377
https://doi.org/10.1158/1538-7445.am2013-2747
https://doi.org/10.1158/1538-7445.am2013-2747