Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kam-Wing Jair"'
Autor:
Lindsay M. De Biase, Raffaello Cimbro, Kornel E. Schuebel, Wendy Xin, Antonello Bonci, Kam wing Jair, David Goldman
Publikováno v:
Neuropsychopharmacology
Astrocytes are ubiquitous CNS cells that support tissue homeostasis through ion buffering, neurotransmitter recycling, and regulation of CNS vasculature. Yet, despite the essential functional roles they fill, very little is known about the physiology
Publikováno v:
Cancer Research. 66:729-735
Previous work has shown that DNA hypermethylation of tumor suppressor genes in colorectal cancer cells may be maintained in the absence of the major mammalian methyltransferase, DNA methyltransferase 1 (DNMT1). In an effort to dissect the dependency
Autor:
Kornel E. Schuebel, Kurtis E. Bachman, Ray Whay Chiu Yen, Hiromu Suzuki, Angela H. Ting, Ina Rhee, Kam Wing Jair, Stephen B. Baylin
Publikováno v:
Cancer Research. 66:682-692
A major obstacle toward understanding how patterns of abnormal mammalian cytosine DNA methylation are established is the difficulty in quantitating the de novo methylation activities of DNA methyltransferases (DNMT) thought to catalyze these reaction
Autor:
Chun Yan Ren, Manon van Engeland, Hiromu Suzuki, Yoshimitsu Akiyama, James G. Herman, Manel Esteller, Kam Wing Jair, Stephen B. Baylin, Yasuhito Yuasa, D. Neil Watkins, Hidekazu Sakai
Publikováno v:
Molecular and Cellular Biology. 23:8429-8439
The GATA family of transcription factors participates in gastrointestinal (GI) development. Increases in GATA-4 and -5 expression occur in differentiation and GATA-6 expression in proliferation in embryonic and adult settings. We now show that in col
Autor:
Takashi Tokino, Kazuhiro Ogi, Kohzoh Imai, Takefumi Kikuchi, Jean Pierre J. Issa, Yasushi Sasaki, Minoru Toyota, Hiromu Suzuki, Kam Wing Jair, Ayumi Satoh, Kornel E. Schuebel, Nobuyuki Tanaka, Hiroaki Mita, Fumio Itoh
Publikováno v:
Proceedings of the National Academy of Sciences. 100:7818-7823
Cell-cycle checkpoints controlling the orderly progression through mitosis are frequently disrupted in human cancers. One such checkpoint, entry into metaphase, is regulated by the CHFR gene encoding a protein possessing forkhead-associated and RING
Autor:
Christoph Lengauer, Stephen B. Baylin, Ina Rhee, Ray Whay Chiu Yen, Hengmi Cui, Andrew P. Feinberg, Kurtis E. Bachman, Bert Vogelstein, Ben Ho Park, Kenneth W. Kinzler, Kornel E. Schuebel, Kam Wing Jair
Publikováno v:
Nature. 416:552-556
Inactivation of tumour suppressor genes is central to the development of all common forms of human cancer. This inactivation often results from epigenetic silencing associated with hypermethylation rather than intragenic mutations. In human cells, th
Autor:
Beat Thöny, Kirsten Skarstad, Xin Yu, Kam Wing Jair, Nobuyuki Fujita, Akira Ishihama, Richard E. Wolf
Publikováno v:
Journal of Bacteriology. 178:2507-2513
The Rob protein, isolated on the basis of its ability to bind to the right arm of the Escherichia coli origin of chromosomal replication, is about 50% identical in amino acid sequence to SoxS and MarA, the direct regulators of the superoxide (soxRS)
Autor:
Ting, Angela H.1,2, Kam-Wing Jair2, Suzuki, Hiromu2, Ray-Whay Chiu Yen2, Baylin, Stephen B.1,2 sbaylin@jhmi.edu, Schuebel, Kornel E.2 kornels@jhmi.edu
Publikováno v:
Nature Genetics. Jun2004, Vol. 36 Issue 6, p582-584. 3p.
Autor:
Hiromu Suzuki, Angela H. Ting, Ray Whay Chiu Yen, Kam Wing Jair, Stephen B. Baylin, Kornel E. Schuebel
Publikováno v:
Cell Cycle. 3:1022-1024
The role of DNA methyltransferase 1, DNMT1, in human cancer cells has recently been contested. In this setting, DNMT1’s function as the sole maintenance methyltransferase was based on the assumption that its biological activity is identical to the
Autor:
Debby M.E.I. Hellebrekers, Manon van Engeland, Emmanuelle Viré, Sayaka Eguchi, Stephen B. Baylin, Nicole Hoebers, Mario F. Fraga, Arjan W. Griffioen, François Fuks, Manel Esteller, Kam Wing Jair
Publikováno v:
Molecular Cancer Therapeutics, 5(2), 467-75. American Association for Cancer Research Inc.
Inhibitors of DNA methyltransferases (DNMT) and histone deacetylases can reactivate epigenetically silenced tumor suppressor genes and thereby decrease tumor cell growth. Little, however, is known on the effects of these compounds in endothelial cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7f098cb7c8ff9a1e39d0e1810d94af
https://cris.maastrichtuniversity.nl/en/publications/cc267b5f-a8a3-4320-9450-7ed34626c4b2
https://cris.maastrichtuniversity.nl/en/publications/cc267b5f-a8a3-4320-9450-7ed34626c4b2