Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Kam Y J Zhang"'
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75762 (2013)
One of the underlying principles in drug discovery is that a biologically active compound is complimentary in shape and molecular recognition features to its receptor. This principle infers that molecules binding to the same receptor may share some c
Externí odkaz:
https://doaj.org/article/ec45505f8aa64ca6afd98e438ef509d8
Autor:
David Simoncini, Kam Y J Zhang
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68954 (2013)
Fragment assembly is a powerful method of protein structure prediction that builds protein models from a pool of candidate fragments taken from known structures. Stochastic sampling is subsequently used to refine the models. The structures are first
Externí odkaz:
https://doaj.org/article/4ec6acbde5fe4d56b6dae532837f4689
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e38799 (2012)
Conformational sampling is one of the bottlenecks in fragment-based protein structure prediction approaches. They generally start with a coarse-grained optimization where mainchain atoms and centroids of side chains are considered, followed by a fine
Externí odkaz:
https://doaj.org/article/ac0972fe533943f886e4f1d6b9473e36
Autor:
Chunlai Tam, Mutsuko Kukimoto-Niino, Yukako Miyata-Yabuki, Kengo Tsuda, Chiemi Mishima-Tsumagari, Kentaro Ihara, Mio Inoue, Mayumi Yonemochi, Kazuharu Hanada, Takehisa Matsumoto, Mikako Shirouzu, Kam Y. J. Zhang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Structural analysis of the Ras-binding domain (RBD) of ELMO1 alone and in complex with the activator RhoG enables rational engineering and validation of a nanobody targeting ELMO1 RBD.
Externí odkaz:
https://doaj.org/article/57ffcbf5665046feb62686a925bac3cb
Autor:
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, Nobumasa Takasugi, Kunishige Onuma, Mitsuhiko Osaki, Futoshi Okada, Taichi Ukegawa, Yasuo Takeuchi, Norihisa Yasui, Atsuko Yamashita, Hiroyuki Marusawa, Yosuke Matsushita, Toyomasa Katagiri, Takahiro Shibata, Koji Uchida, Sheng-Yong Niu, Nhi B. Lang, Tomohiro Nakamura, Kam Y. J. Zhang, Stuart A. Lipton, Takashi Uehara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Here the authors demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by nitric oxide (NO). They also isolate a unique modulator (DBIC) that inhibits S-nitrosylation of DNMT3B, which mitigates cell proliferation and tumorigenic co
Externí odkaz:
https://doaj.org/article/2948479591604774a634757fd4634fae
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired humoral immune responses as
Externí odkaz:
https://doaj.org/article/d5db331983f84cb593eb79e9d7a91011
Autor:
Naveen Kumar, Rahul Kaushik, Ashutosh Singh, Vladimir N. Uversky, Kam Y. J. Zhang, Upasana Sahu, Sandeep Bhatia, Aniket Sanyal
Publikováno v:
Viruses, Vol 14, Iss 12, p 2764 (2022)
The ongoing evolution of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has resulted in the recent emergence of a highly divergent variant of concern (VOC) defined as Omicron or B.1.1.529. This VOC is of particular concern because it ha
Externí odkaz:
https://doaj.org/article/93428360d8ce4472b14f8dc6f3ab6219
Identification of Fungal and Bacterial Denitrification Inhibitors Targeting Copper Nitrite Reductase
Publikováno v:
Journal of Agricultural and Food Chemistry. 71:5172-5184
Autor:
Naveen Kumar, Rahul Kaushik, Kam Y. J. Zhang, Vladimir N. Uversky, Upasana Sahu, Richa Sood, Sandeep Bhatia
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 91:798-806
Autor:
Kundan Solanki, Sajjan Rajpoot, Ashutosh Kumar, Kam Y J Zhang, Tomokazu Ohishi, Nik Hirani, Khandu Wadhonkar, Pramod Patidar, Qiuwei Pan, Mirza S Baig
Publikováno v:
Future Virology, 17(10), 723-732. Future Medicine Ltd.
Aim: Mutations in the SARS-CoV-2 spike (S) protein have dramatically changed the transmissibility and pathogenicity of the virus. Therefore, we studied the binding affinity of Omicron spike-receptor binding domain (S-RBD) with human ACE2 receptor. Ma