ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer.

Autor: Wong TL; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China., Loh JJ; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Lu S; Department of Pathology, Sun Yat-Sen University Cancer Centre, Guangzhou, Guangdong, China., Yan HHN; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China., Siu HC; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China., Xi R; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Chan D; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China., Kam MJF; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Zhou L; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China., Tong M; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.; The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China.; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Copland JA; Department of Cancer Biology, Mayo Clinic Florida, Jacksonville, FL, USA., Chen L; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Yun JP; Department of Pathology, Sun Yat-Sen University Cancer Centre, Guangzhou, Guangdong, China., Leung SY; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.; The Jockey Club Centre for Clinical Innovation and Discovery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Ma S; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. stefma@hku.hk.; The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China. stefma@hku.hk.

Publikováno v: Nature communications [Nat Commun] 2023 May 19; Vol. 14 (1), pp. 2861. Date of Electronic Publication: 2023 May 19.