Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kam Gohil"'
Autor:
Lisa E. Ranshaw, Tracy Jane Shipley, Suzanne Elaine Keeling, Colin David Eldred, Nicola Mary Aston, B. Judkins, Ed Robinson, Kam Gohil, Naimisha Trivedi, Christopher James Lunniss, Andy Craven
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:137-140
Species specific conversion of the lead PDE4 inhibitor 1 to the quinolone 3 was identified as the major route of metabolism in the cynomolgus monkey. Modification of the template to give the cinnoline 9 retained potency and selectivity, and greatly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb271e1e882da928f3b0ee05c4c9fb31
https://doi.org/10.1016/j.bmcl.2009.11.010
https://doi.org/10.1016/j.bmcl.2009.11.010
Autor:
Adeline Walters, Roger W. Randall, Stuart G. Cockerill, Kam Gohil, Clive Yeates, Nigel R. Parry, R.W. Bonser, Ed Robinson, Robert Baxter, Martin John Slater, Wendy Snowden
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1993-1995
The synthesis and antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure–activity relationships in this series against human cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70489376f45fb8f68bd5da9cdaf6f98
https://doi.org/10.1016/s0960-894x(01)00352-3
https://doi.org/10.1016/s0960-894x(01)00352-3
Autor:
Edward Littler, Martin John Slater, Stuart Cockerill, Robert W. Bonser, Nigel R. Parry, Wendy Snowden, Robert Baxter, Kam Gohil, Clare Gowrie, Roger W. Randall, J.Edward Robinson
Publikováno v:
Bioorganicmedicinal chemistry. 7(6)
In our search for new, safer anti-HCMV agents, we discovered that the natural product Arcyriaflavin A (la) was a potent inhibitor of HCMV replication in cell culture. A series of analogues (symmetrical indolocarbazoles) was synthesised to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b37b23eaa7cc6982a37c67c99023e9
https://pubmed.ncbi.nlm.nih.gov/10428375
https://pubmed.ncbi.nlm.nih.gov/10428375