Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kalyani Jambunathan"'
Autor:
Huifen Ding, Kalyani Jambunathan, Guochun Jiang, David M. Margolis, Iris Leng, Michael Ihnat, Jian-Xing Ma, Jon Mirsalis, Yuanyuan Zhang
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1042 (2022)
Mitochondrial toxicity (Mito-Tox) risk has increased due to the administration of several classes of drugs, particularly some life-long antiretroviral drugs for HIV+ individuals. However, no suitable in vitro assays are available to test long-term Mi
Externí odkaz:
https://doaj.org/article/4edd98a16a124c7d8b2c51a623bc668d
Autor:
Ashley N. Brown, George L. Drusano, Jonathan R. Adams, Jaime L. Rodriquez, Kalyani Jambunathan, Dodge L. Baluya, David L. Brown, Awewura Kwara, Jon C. Mirsalis, Richard Hafner, Arnold Louie
Publikováno v:
mBio, Vol 6, Iss 6 (2015)
ABSTRACT Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis. Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhibition of mitochondrial prot
Externí odkaz:
https://doaj.org/article/0a8207688af7408c9f377cb7543d327b
Publikováno v:
BioTechniques, Vol 51, Iss 2, Pp 95-104 (2011)
Proteases are candidate biomarkers and therapeutic targets for many diseases. Sensitive and robust techniques are needed to quantify proteolytic activities within the complex biological milieu. We hypothesized that a combinatorial protease substrate
Externí odkaz:
https://doaj.org/article/b3eee29f09e54cf88210f7b9f811c0c2
Autor:
Douglas S Watson, Xizhi Feng, David S Askew, Kalyani Jambunathan, Krishna Kodukula, Amit K Galande
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21001 (2011)
The filamentous fungus Aspergillus fumigatus (AF) can cause devastating infections in immunocompromised individuals. Early diagnosis improves patient outcomes but remains challenging because of the limitations of current methods. To augment the clini
Externí odkaz:
https://doaj.org/article/7adfcdfa19da47a8b13c53a593d93d9f
Autor:
Margaret V Powers-Fletcher, Kalyani Jambunathan, Jordan L Brewer, Karthik Krishnan, Xizhi Feng, Amit K Galande, David S Askew
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28865 (2011)
Calnexin is a membrane-bound lectin chaperone in the endoplasmic reticulum (ER) that is part of a quality control system that promotes the accurate folding of glycoproteins entering the secretory pathway. We have previously shown that ER homeostasis
Externí odkaz:
https://doaj.org/article/0076ab3ad40845b793d59adae349f017
Autor:
Benben Song, Kalyani Jambunathan, Patrick Kibler, Aaron N. Endsley, Surendra Kumar Nayak, Amit K. Galande
Publikováno v:
Chemical Biology & Drug Design. 86:1433-1437
Hemopressin is a naturally occurring and therapeutically relevant peptide with applications in hypertension, pain, addiction, and obesity. We had previously demonstrated that hemopressin converts into amyloid-like fibrils under aqueous conditions. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b2272d5a5979eae3e273f58260e806
https://doi.org/10.1111/cbdd.12610
https://doi.org/10.1111/cbdd.12610
Autor:
Amit K. Galande, Kalyani Jambunathan
Publikováno v:
PROTEOMICS - Clinical Applications. 8:299-307
Purpose Proteolytic enzymes are promising diagnostic targets since they play key roles in diverse physiological processes and have been implicated in numerous human diseases. Human blood is a relatively noninvasive source for disease-specific proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435635a7461c044685b765a46e7032c2
https://doi.org/10.1002/prca.201300037
https://doi.org/10.1002/prca.201300037
Autor:
Kalyani Jambunathan, Amit K. Galande
Publikováno v:
Protein & Peptide Letters. 21:32-38
Serum has a high intrinsic proteolytic activity that leads to continuous processing of peptides and proteins. Strategies to protect bioactive peptides from serum proteolytic degradation include incorporation of unnatural amino acids, conformational c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f3a412e8b0705035f3623f214563d3
https://doi.org/10.2174/09298665113209990069
https://doi.org/10.2174/09298665113209990069
Autor:
Douglas S. Watson, Laura K. Najvar, Amit K. Galande, William R. Kirkpatrick, Thomas F. Patterson, David S. Askew, Krishna Kodukula, Nathan P. Wiederhold, Kalyani Jambunathan
Publikováno v:
Medical Mycology. 51:592-602
Improved diagnostics are needed to detect invasive pulmonary aspergillosis, a life-threatening infection caused by the pathogenic fungus Aspergillus fumigatus . We are investigating secreted fungal proteases as novel biomarkers for the diagnosis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599609bc7fdb6d8c385093e98b1f5b64
https://doi.org/10.3109/13693786.2012.761360
https://doi.org/10.3109/13693786.2012.761360
Publikováno v:
Drug Development Research. 74:81-91
Preclinical Research Proteases play an important role in many cellular functions and represent promising biomarkers in addition to being targets for many diseases ranging from cardiovascular and neurological disorders to respiratory problems and canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60b123b5f7356a2f6e5640759cc6fcc9
https://doi.org/10.1002/ddr.21062
https://doi.org/10.1002/ddr.21062