Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kalyan S. Chakrabarti"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract A complex interplay between various processes underlies the neuropathology of Alzheimer’s disease (AD) and its progressive course. Several lines of evidence point to the coupling between Aβ aggregation and neuroinflammation and its role i
Externí odkaz:
https://doaj.org/article/59860d9f1319420095994f8d230905ad
Autor:
Kalyan S. Chakrabarti, Simon Olsson, Supriya Pratihar, Karin Giller, Kerstin Overkamp, Ko On Lee, Vytautas Gapsys, Kyoung-Seok Ryu, Bert L. de Groot, Frank Noé, Stefan Becker, Donghan Lee, Thomas R. Weikl, Christian Griesinger
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The authors provide a litmus test for the recognition mechanism of transiently binding proteins based on nuclear magnetic resonance and find a conformational selection binding mechanism through concentration-dependent kinetics of ubiquitin and SH3.
Externí odkaz:
https://doaj.org/article/e8ba332421814557b30a7a29637552f0
Autor:
Kalyan S. Chakrabarti, Roman V. Agafonov, Francesco Pontiggia, Renee Otten, Matthew K. Higgins, Gebhard F.X. Schertler, Daniel D. Oprian, Dorothee Kern
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 32-42 (2016)
Molecular recognition plays a central role in biology, and protein dynamics has been acknowledged to be important in this process. However, it is highly debated whether conformational changes happen before ligand binding to produce a binding-competen
Externí odkaz:
https://doaj.org/article/4046190bf416435697bf9fbeb119b1d5
Autor:
Rashmi Agrata, Priyesh Mohanty, Aravind Ravichandran, Sanju Kumari, Nishant Varshney, GS Arun, Kanchan Chauhan, Jess Li, Kalyan S. Chakrabarti, R. Andrew Byrd, Ranabir Das
The deamidases secreted byBurkholderia pseudomalleiandEnteropathogenic Ecolimodify the residue 40 in ubiquitin from a Glutamine (Q) to Glutamate (E), triggering several downstream processes to cause cell cycle arrest and activate immune responses. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c155ad57c471d5ee10a7d8388d135ae
https://doi.org/10.1101/2023.05.22.541748
https://doi.org/10.1101/2023.05.22.541748
Stability, convergence and bifurcation of a reduced Boissonade-De Kepper model with delayed feedback
Publikováno v:
IFAC-PapersOnLine. 54:76-83
Autor:
Smita K. Nair, Khushboo Kumari, N. Megha Karanth, Handanahal S. Savithri, Kalyan S. Chakrabarti, Siddhartha P. Sarma, Karuna Dixit
Publikováno v:
Biochemistry. 59:4663-4680
The plant Sesbania mosaic virus [a (+)-ssRNA sobemovirus] VPg protein is intrinsically disordered in solution. For the virus life cycle, the VPg protein is essential for replication and for polyprotein processing that is carried out by a virus-encode
Autor:
Kalyan S. Chakrabarti, Mathias Bähr, Anupam Raina, Christian Griesinger, Sameehan Mahajani, Stefan Becker, Diana Voll, Sebastian Kügler, Kristian Leite, Sofia Guerin
Publikováno v:
Journal of Neurochemistry. 156:674-691
A contribution of α-Synuclein (α-Syn) to etiology of Parkinson´s disease (PD) and Dementia with Lewy bodies (DLB) is currently undisputed, while the impact of the closely related β-Synuclein (β-Syn) on these disorders remains enigmatic. β-Syn h
Autor:
Myeongkyu Kim, Jung-Hye Ha, Joonhyeok Choi, Bo-Ram Kim, Vytautas Gapsys, Ko On Lee, Jun-Goo Jee, Kalyan S. Chakrabarti, Bert L. de Groot, Christian Griesinger, Kyoung-Seok Ryu, Donghan Lee
Publikováno v:
Journal of medicinal chemistry. 65(3)
Biliverdin IXβ reductase B (BLVRB) has recently been proposed as a novel therapeutic target for thrombocytopenia through its reactive oxygen species (ROS)-associated mechanism. Thus, we aim at repurposing drugs as new inhibitors of BLVRB. Based on I
Autor:
Karuna, Dixit, N Megha, Karanth, Smita, Nair, Khushboo, Kumari, Kalyan S, Chakrabarti, Handanahal S, Savithri, Siddhartha P, Sarma
Publikováno v:
Biochemistry. 59(49)
The plant
Publikováno v:
Structure
Conformational dynamics plays a fundamental role in molecular recognition and activity in enzymes. The ubiquitin-conjugating enzyme (E2) Ube2g2 functions with the ubiquitin ligase (E3) gp78 to assemble poly-ubiquitin chains on target substrates. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624050a0267a846bd8ece91d985bfec4
https://hdl.handle.net/11858/00-001M-0000-002D-598F-B11858/00-001M-0000-002D-598A-611858/00-001M-0000-002D-598D-F11858/00-001M-0000-002D-598E-D11858/00-001M-0000-002D-5990-511858/00-001M-0000-002D-598C-2
https://hdl.handle.net/11858/00-001M-0000-002D-598F-B11858/00-001M-0000-002D-598A-611858/00-001M-0000-002D-598D-F11858/00-001M-0000-002D-598E-D11858/00-001M-0000-002D-5990-511858/00-001M-0000-002D-598C-2