Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kalyan C. Vinnakota"'
Autor:
Bonnie V. Dougherty, Kristopher D. Rawls, Glynis L. Kolling, Kalyan C. Vinnakota, Anders Wallqvist, Jason A. Papin
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108836- (2021)
Summary: In diseased states, the heart can shift to use different carbon substrates, measured through changes in uptake of metabolites by imaging methods or blood metabolomics. However, it is not known whether these measured changes are a result of t
Externí odkaz:
https://doaj.org/article/f11fdfb8df8c425fb8412d81b59ad1ea
Autor:
Kalyan C. Vinnakota, Venkat R. Pannala, Martha L. Wall, Mohsin Rahim, Shanea K. Estes, Irina Trenary, Tracy P. O’Brien, Richard L. Printz, Jaques Reifman, Masakazu Shiota, Jamey D. Young, Anders Wallqvist
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The liver—a central metabolic organ that integrates whole-body metabolism to maintain glucose and fatty-acid regulation, and detoxify ammonia—is susceptible to injuries induced by drugs and toxic substances. Although plasma metabolite profiles ar
Externí odkaz:
https://doaj.org/article/31160d3a38544dea8291b4a19412e827
Autor:
Jaques Reifman, Richard L. Printz, Tatsuya Oyama, Kalyan C. Vinnakota, Shanea K. Estes, Jamey D. Young, Venkat R. Pannala, Masakazu Shiota, Jason A. Papin, Irina Trenary, Tracy P OˈBrien, Anders Wallqvist
Publikováno v:
Toxicol Sci
Identifying early indicators of toxicant-induced organ damage is critical to provide effective treatment. To discover such indicators and the underlying mechanisms of toxicity, we used gentamicin as an exemplar kidney toxicant and performed systemati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2256b2c329caa57764a68ed2d245735
https://doi.org/10.1093/toxsci/kfz228
https://doi.org/10.1093/toxsci/kfz228
Autor:
Kalyan C. Vinnakota, Glynis L. Kolling, Bonnie V. Dougherty, Kristopher D. Rawls, Jason A. Papin, Anders Wallqvist
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108836-(2021)
Summary In diseased states, the heart can shift to use different carbon substrates, measured through changes in uptake of metabolites by imaging methods or blood metabolomics. However, it is not known whether these measured changes are a result of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046e52bb7ce0398942ead1090eda6942
http://www.sciencedirect.com/science/article/pii/S2211124721001509
http://www.sciencedirect.com/science/article/pii/S2211124721001509
Autor:
Kalyan C. Vinnakota, Anders Wallqvist, Glynis L. Kolling, Bonnie V. Dougherty, Jason A. Papin, Kristopher D. Rawls
SummaryThe heart is a metabolic omnivore, known to consume many different carbon substrates in order to maintain function. In diseased states, the heart’s metabolism can shift between different carbon substrates; however, there is some disagreement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cd85b0c6c6e589bb0187321c6fa1397
https://doi.org/10.1101/2020.07.20.212274
https://doi.org/10.1101/2020.07.20.212274
Autor:
Glynis L. Kolling, Bonnie V. Dougherty, Kalyan C. Vinnakota, Anders Wallqvist, Kristopher D. Rawls, Edik M. Blais, Jason A. Papin, Venkat R. Pannala
Publikováno v:
Toxicological Sciences
Context-specific GEnome-scale metabolic Network REconstructions (GENREs) provide a means to understand cellular metabolism at a deeper level of physiological detail. Here, we use transcriptomics data from chemically-exposed rat hepatocytes to constra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2327dfa8f52b9f01b7a67d86e861ea46
https://pubmed.ncbi.nlm.nih.gov/31501904
https://pubmed.ncbi.nlm.nih.gov/31501904
Autor:
Richard L. Printz, Anders Wallqvist, Kristopher D. Rawls, Venkat R. Pannala, Jason A. Papin, Jaques Reifman, Masakazu Shiota, Shanea K. Estes, Jamey D. Young, Kalyan C. Vinnakota, Tracy P. O’Brien
Publikováno v:
Toxicol Appl Pharmacol
Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug in the world. Yet, it poses a major risk of liver injury when taken in excess of the therapeutic dose. Current clinical markers do not detect the early onset of liver injur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441840f2e7ff4271e3c90009e3deb98a
https://pubmed.ncbi.nlm.nih.gov/30974156
https://pubmed.ncbi.nlm.nih.gov/30974156
Autor:
Kristopher D. Rawls, Bonnie V. Dougherty, Kalyan C. Vinnakota, Anders Wallqvist, Jason A. Papin, Glynis L. Kolling, Venkat R. Pannala
Publikováno v:
Toxicol Appl Pharmacol
The kidneys are metabolically active organs with importance in several physiological tasks such as the secretion of soluble wastes into the urine and synthesizing glucose and oxidizing fatty acids for energy in fasting (non-fed) conditions. Once dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dbe0831d4dae15827c910c4bd2afbf
https://doi.org/10.1016/j.taap.2020.115390
https://doi.org/10.1016/j.taap.2020.115390
Publikováno v:
Biophysical Journal. 110(4):962-971
Competing models of mitochondrial energy metabolism in the heart are highly disputed. In addition, the mechanisms of reactive oxygen species (ROS) production and scavenging are not well understood. To deepen our understanding of these processes, a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013b16ad42cea7e7bd16ec2c6cb4989f
Autor:
Kalyan C. Vinnakota, Robert W. Wiseman, Françoise Van den Bergh, Masoumeh Bagher-Oskouei, Daniel A. Beard, Abhishek Singhal
Publikováno v:
Biophysical Journal. 110(4):954-961
In cardiac muscle, mitochondrial ATP synthesis is driven by demand for ATP through feedback from the products of ATP hydrolysis. However, in skeletal muscle at higher workloads there is an apparent contribution of open-loop stimulation of ATP synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695fac7ddda182bdff038ba1b6e8e7b3