Výsledky vyhledávání - "Kalverda, AP"

Generating Ensembles of Dynamic Misfolding Proteins

Autor: Karamanos, TK, Kalverda, AP, Radford, SE

Publikováno v: Frontiers in neuroscience. 16

The early stages of protein misfolding and aggregation involve disordered and partially folded protein conformers that contain a high degree of dynamic disorder. These dynamic species may undergo large-scale intra-molecular motions of intrinsically d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bcd3125a7b14ada5541bdab8ef5f63
https://pubmed.ncbi.nlm.nih.gov/35431773

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Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase

Autor: Drulyte, I, Obajdin, J, Trinh, CH, Kalverda, AP, van der Kamp, MW, Hemsworth, GR, Berry, A

Publikováno v: IUCrJ
Drulyte, I, Obajdin, J, Trinh, C H, Kalverda, A, Van der Kamp, M W, Hemsworth, G R & Berry, A 2019, ' Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase ', IUCrJ, vol. 6, no. 6, pp. 1120-1133 . https://doi.org/10.1107/S2052252519012399
IUCrJ, Vol 6, Iss 6, Pp 1120-1133 (2019)
'IUCrJ ', vol: 6, pages: 1120-1133 (2019)

The crystal structure of IdmH from the biosynthetic gene cluster for indanomycin is presented. NMR data show that this enzyme binds its postulated product, indanomycin, and QM/MM modelling of the reaction strongly supports the view that IdmH catalyse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fbc8c8f097684919718daf5ebd73be81
http://europepmc.org/articles/PMC6830212

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The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A

Autor: Monteiro, DCF, Patel, V, Bartlett, CP, Nozaki, S, Grant, TD, Gowdy, JA, Thompson, GS, Kalverda, AP, Snell, EH, Niki, H, Pearson, AR, Webb, ME

Publikováno v: Chemistry & Biology. 22(4):492-503

SummaryCoenzyme A (CoA) is an ubiquitous and essential cofactor, synthesized from the precursor pantothenate. Vitamin biosynthetic pathways are normally tightly regulated, including the pathway from pantothenate to CoA. However, no regulation of pant

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Visualization of Transient Protein-Protein Interactions that Promote or Inhibit Amyloid Assembly

Autor: Karamanos, TK, Kalverda, AP, Thompson, GS, Radford, SE

Publikováno v: Molecular Cell. 55(2):214-226

In the early stages of amyloid formation, heterogeneous populations of oligomeric species are generated, the affinity, specificity, and nature of which may promote, inhibit, or define the course of assembly. Despite the importance of the intermolecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4c6f025857fd65a18207c1025e09096e

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A population shift between sparsely populated folding intermediates determines amyloidogenicity

Autor: Karamanos, TK, Pashley, CL, Kalverda, AP, Thompson, GS, Mayzel, M, Orekhov, VY, Radford, SE

The balance between protein folding and misfolding is a crucial determinant of amyloid assembly. Transient intermediates that are sparsely populated during protein folding have been identified as key players in amyloid aggregation. However, due to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a13013529b2214acafa609da46626ee6
https://kar.kent.ac.uk/71794/1/jacs.6b02464.pdf

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Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

Autor: Foster, TL, Thompson, GS, Kalverda, AP, Kankanala, J, Bentham, M, Wetherill, LF, Thompson, J, Barker, AM, Clarke, D, Noerenberg, M, Pearson, AR, Rowlands, D. J., Homans, SW, Harris, M, Foster, R, Griffin, S

Publikováno v: Hepatology (Baltimore, Md.)

Current interferon-based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct-acting antivirals (DAA) with the first protease-targeted drugs licensed in 2012. Many compounds are in the pipeline

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¹H, ¹?N, and ¹³C backbone chemical shift assignment of titin domains A59-A60 and A60 alone

Autor: Czajlik, A, Thompson, GS, Khan, GN, Kalverda, AP, Homans, SW, Trinick, J

The giant protein titin is the third most abundant protein of vertebrate striated muscle. The titin molecule is > 1 ?m long and spans half the sarcomere, from the Z-disk to the M-line, and has important roles in sarcomere assembly, elasticity and int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::69a529bd8d5b8d1cbfde14d29444497a
https://kar.kent.ac.uk/71800/1/Czajlik2014_Article_1H15NAnd13CBackboneChemicalShi.pdf

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