In vivo polarisation sensitive optical coherence tomography for fibrosis assessment in interstitial lung disease: a prospective, exploratory, observational study

Autor: Michael W T Tanck, Onno M Mets, Erik Thunnissen, Jouke T Annema, Peter I Bonta, Inge A H van den Berk, Margherita Vaselli, Kirsten Kalverda-Mooij, Johannes F de Boer

Publikováno v: BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)

Introduction Endobronchial polarisation sensitive optical coherence tomography (EB-PS-OCT) is a bronchoscopic imaging technique exceeding resolution of high-resolution CT (HRCT) by 50-fold. It detects collagen birefringence, enabling identification a

Externí odkaz: https://doaj.org/article/5cd12ee71d6c4ff7923b1b0b0b041585

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Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infectionResearch in context

Autor: Lihui Guo, Brent Appelman, Kirsten Mooij-Kalverda, Riekelt H. Houtkooper, Michel van Weeghel, Frédéric M. Vaz, Annemiek Dijkhuis, Tamara Dekker, Barbara S. Smids, Jan Willem Duitman, Marianna Bugiani, Paul Brinkman, Jonne J. Sikkens, H.A. Ayesha Lavell, Rob C.I. Wüst, Michèle van Vugt, René Lutter, M.A. van Agtmael, A.G. Algera, B. Appelman, F.E.H.P. van Baarle, M. Beudel, H.J. Bogaard, M. Bomers, P.I. Bonta, L.D.J. Bos, M. Botta, J. de Brabander, G.J. de Bree, S. de Bruin, M. Bugiani, E.B. Bulle, O. Chouchane, A.P.M. Cloherty, D. Buis, M.C.F.J. de Rotte, M. Dijkstra, D.A. Dongelmans, R.W.G. Dujardin, P.E. Elbers, L.M. Fleuren, S.E. Geerlings, T.B.H. Geijtenbeek, A.R.J. Girbes, A. Goorhuis, M.P. Grobusch, L.A. Hagens, J. Hamann, V.C. Harris, R. Hemke, S.M. Hermans, L.M.A. Heunks, M.W. Hollmann, J. Horn, J.W. Hovius, M.D. de Jong, R. Koing, E.H.T. Lim, N. van Mourik, J.F. Nellen, E.J. Nossent, F. Paulus, E. Peters, D. Piña-Fuentes, T. van der Poll, B. Preckel, J.M. Prins, S.J. Raasveld, T.D.Y. Reijnders, M. Schinkel, F.A.P. Schrauwen, M.J. Schultz, A.R. Schuurman, J. Schuurmans, K. Sigaloff, M.A. Slim, P. Smeele, M.R. Smit, C. Stijnis, W. Stilma, C.E. Teunissen, P. Thoral, A.M. Tsonas, P.R. Tuinman, M. van der Valk, D.P. Veelo, C. Volleman, H. de Vries, L.A. van Vught, M. van Vugt, D. Wouters, A.H. Zwinderman, M.C. Brouwer, W.J. Wiersinga, A.P.J. Vlaar, D. van de Beek

Publikováno v: EBioMedicine, Vol 94, Iss , Pp 104729- (2023)

Summary: Background: Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/seve

Externí odkaz: https://doaj.org/article/d01232b4f65044ae908001bceb0907e4

Leukocyte differentiation in bronchoalveolar lavage fluids using higher harmonic generation microscopy and deep learning

Autor: Laura M. G. van Huizen, Max Blokker, Yael Rip, Mitko Veta, Kirsten A. Mooij Kalverda, Peter I. Bonta, Jan Willem Duitman, Marie Louise Groot

Publikováno v: PLoS ONE, Vol 18, Iss 6 (2023)

Background In diseases such as interstitial lung diseases (ILDs), patient diagnosis relies on diagnostic analysis of bronchoalveolar lavage fluid (BALF) and biopsies. Immunological BALF analysis includes differentiation of leukocytes by standard cyto

Externí odkaz: https://doaj.org/article/da77b1ae39df442d860f04fc99a19118

Grb2 binding induces phosphorylation-independent activation of Shp2

Autor: Chi-Chuan Lin, Lukasz Wieteska, Kin Man Suen, Arnout P. Kalverda, Zamal Ahmed, John E. Ladbury

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of

Externí odkaz: https://doaj.org/article/edb9c4facda0446e8198cbaac3dd988c