Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kalum Clayton"'
Autor:
Sofia Sirvent, Andres F. Vallejo, Emma Corden, Ying Teo, James Davies, Kalum Clayton, Eleanor G. Seaby, Chester Lai, Sarah Ennis, Rfeef Alyami, Gemma Douilhet, Lareb S. N. Dean, Matthew Loxham, Sarah Horswill, Eugene Healy, Graham Roberts, Nigel J. Hall, Peter S. Friedmann, Harinder Singh, Clare L. Bennett, Michael R Ardern-Jones, Marta E. Polak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human in vivo allergen challenge stud
Externí odkaz:
https://doaj.org/article/8a9e3b6f395949309fb497cf8ddaabc0
Autor:
James Davies, Sofia Sirvent, Andres F. Vallejo, Kalum Clayton, Gemma Douilhet, Patrick S. Keeler, Jonathan West, Michael Ardern-Jones, Ben D. MacArthur, Harinder Singh, Marta E. Polak
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human epidermal Langerhans cells (LCs) maintain immune homeostasis in the skin. To examine transcriptional programming of human primary LCs during homeostasis, we performed scRNA-seq analysis of LCs before and after migration from the epidermis, coup
Externí odkaz:
https://doaj.org/article/01eb019a31594305b0a55201ee8ed5e5
Autor:
Sofia Sirvent, Andres F. Vallejo, James Davies, Kalum Clayton, Zhiguo Wu, Jeongmin Woo, Jeremy Riddell, Virendra K. Chaudhri, Patrick Stumpf, Liliya Angelova Nazlamova, Gabrielle Wheway, Matthew Rose-Zerilli, Jonathan West, Mario Pujato, Xiaoting Chen, Christopher H. Woelk, Ben MacArthur, Michael Ardern-Jones, Peter S. Friedmann, Matthew T. Weirauch, Harinder Singh, Marta E. Polak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulate
Externí odkaz:
https://doaj.org/article/b437083920e842f086e6d17c31b3b048
Autor:
James Davies, Andres F. Vallejo, Sofia Sirvent, Gemma Porter, Kalum Clayton, Yamkela Qumbelo, Patrick Stumpf, Jonathan West, Clive M. Gray, Nyaradzo T. L. Chigorimbo-Murefu, Ben MacArthur, Marta E. Polak
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed ma
Externí odkaz:
https://doaj.org/article/46f330235a8f433f86a4e4a607fe5ba0
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they enco
Externí odkaz:
https://doaj.org/article/bfad3fa1f1d9479a90a9dc3a32cba73f
Autor:
Kalum Clayton, Daniel J Holbrook, Andres Vallejo, Gemma Porter, Sofia Sirvent, James Davies, Jenny Pople, Fei Ling Lim, Myron Christodoulides, Marta E Polak, Michael R Ardern-Jones
Background: acute cutaneous inflammation causes microbiome alterations as well as ultrastructural changes in epidermis stratification. However, the interactions between keratinocyte proliferation and differentiation status and the skin microbiome hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d5ec298a0e84de806912e5c2ce7429
https://eprints.soton.ac.uk/476987/
https://eprints.soton.ac.uk/476987/
Autor:
Kalum Clayton, Andres F. Vallejo, James Davies, Sofia Sirvent, Marta E Polak, F. Lim, Michael R. Ardern-Jones, Gemma Porter, Isabel Reading
Publikováno v:
British Journal of Dermatology. 184:913-922
Background: Atopic dermatitis (AD) arises from a complex interaction between an impaired epidermal barrier, environmental exposures, and the infiltration of T helper (Th)1/Th2/Th17/Th22 T cells. Transcriptomic analysis has advanced our understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb51486127a661673df5890b7ba05ea
https://doi.org/10.1111/bjd.19431
https://doi.org/10.1111/bjd.19431
Autor:
Gemma Douilhet, Mahesan Niranjan, Andres Vallejo, Kalum Clayton, James Davies, Sofia Sirvent, Jenny Pople, Michael R Ardern-Jones, Marta E Polak
The ability to reliably predict and infer cellular responses to environmental exposures would offer a major advance in the investigation of immune regulation in health and disease. One possible approach is the use of in silico modelling. Design of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dadefcbcf687ac49384d8a590c320d3
https://doi.org/10.1101/2022.02.22.481394
https://doi.org/10.1101/2022.02.22.481394
Autor:
Peter S. Friedmann, Kalum Clayton, Rfeef Alyami, Clare L. Bennett, James Davies, Emma Corden, Marta E Polak, Sarah Ennis, Sarah Horswill, Lareb S. N. Dean, Sofia Sirvent, Michael R. Ardern-Jones, Ying Teo, Harinder Singh, Nigel J. Hall, Chester Lai, Eleanor G. Seaby, Andres F. Vallejo, Eugene Healy, Matthew Loxham, Graham Roberts
Accurate regulation of cutaneous immunity is fundamental for human health and quality of life but is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance vs inflammation in human skin, we se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ec72585e094bcb1866edfa427e11d51
https://doi.org/10.1101/2021.10.07.21264714
https://doi.org/10.1101/2021.10.07.21264714
Autor:
Clive M. Gray, Sofia Sirvent, Jonathan West, Marta E Polak, Ben D. MacArthur, Kalum Clayton, Qumbelo Y, Andres F. Vallejo, Gemma Porter, Nyaradzo T. L. Chigorimbo-Murefu, Patrick S. Stumpf, James Davies
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we performed ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::718788a1fe8f59cc56f91c6f5312644e
https://doi.org/10.1101/2021.02.07.430111
https://doi.org/10.1101/2021.02.07.430111