Cytomegalovirus Triplex vaccine in pediatric hematopoietic stem cell transplant patients at high risk for cytomegalovirus complications: evaluation of vaccine safety, immunogenicity and impact on viremia requiring antivirals.

Autor: La Rosa C; Department of Hematology and Hematopoietic Cell Transplantation. clarosa@coh.org., Park Y; Department of Hematology and Hematopoietic Cell Transplantation., Yang D; Department of Hematology and Hematopoietic Cell Transplantation., Zhou Q; Department of Hematology and Hematopoietic Cell Transplantation., Kaltcheva T; Department of Hematology and Hematopoietic Cell Transplantation., Karras N; Department of Pediatrics, City of Hope National Medical Center, Duarte, CA., Cheng J; Department of Pediatrics, City of Hope National Medical Center, Duarte, CA., Sun W; The Janssen Pharmaceutical Companies of Johnson and Johnson, Los Angeles, CA., Diamond DJ; Department of Hematology and Hematopoietic Cell Transplantation., Pawlowska A; Department of Pediatrics, City of Hope National Medical Center, Duarte, CA.

Publikováno v: Haematologica [Haematologica] 2024 Jul 01; Vol. 109 (7), pp. 2303-2308. Date of Electronic Publication: 2024 Jul 01.

Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform.

Autor: Yll-Pico M; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA. myllpico@coh.org., Park Y; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Martinez J; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Iniguez A; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Kha M; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Kim T; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Medrano L; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Nguyen VH; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Kaltcheva T; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Dempsey S; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Chiuppesi F; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Wussow F; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA., Diamond DJ; Department of Hematology and Transplant Center, City of Hope National Medical Center, Duarte, CA, USA.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Mar 30; Vol. 9 (1), pp. 68. Date of Electronic Publication: 2024 Mar 30.

Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus-specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis.

Autor: La Rosa C; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Aldoss I; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Park Y; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Yang D; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Zhou Q; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Gendzekhadze K; Histocompatibility Laboratory, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Kaltcheva T; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Rida W; Biostatistics Consultant, Arlington, Virginia, USA., Dempsey S; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Arslan S; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Artz A; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Ball B; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Nikolaenko L; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Pullarkat VA; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Nakamura R; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA., Diamond DJ; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California, USA.

Publikováno v: American journal of hematology [Am J Hematol] 2023 Apr; Vol. 98 (4), pp. 588-597. Date of Electronic Publication: 2023 Jan 11.

Adoptive transfer of functional SARS-COV-2-specific immunity from donor graft to hematopoietic stem cell transplant recipients.

Autor: La Rosa C; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Chiuppesi F; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Park Y; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Gendzekhadze K; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Zhou Q; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Faircloth K; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Kaltcheva T; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Johnson D; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Ortega Francisco S; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Amanam I; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Otoukesh S; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Pullarkat VA; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Nakamura R; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Diamond DJ; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Forman SJ; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA., Al Malki MM; Department of Hematology and Hematopoietic Cell Transplantation, 2Histocompatibility Laboratory, Department of Hematology and HCT, City of Hope National Medical Center, Duarte, California, USA.

Publikováno v: American journal of hematology [Am J Hematol] 2022 Nov; Vol. 97 (11), pp. E404-E407. Date of Electronic Publication: 2022 Sep 02.

Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial.

Autor: Chiuppesi F; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Zaia JA; Center for Gene Therapy, City of Hope National Medical Center, Duarte, CA, USA., Frankel PH; Department of Biostatistics, City of Hope National Medical Center, Duarte, CA, USA., Stan R; Translational Development Center, City of Hope National Medical Center, Duarte, CA, USA., Drake J; Clinical Trials Office, City of Hope National Medical Center, Duarte, CA, USA., Williams B; Clinical Trials Office, City of Hope National Medical Center, Duarte, CA, USA., Acosta AM; Clinical Trials Office, City of Hope National Medical Center, Duarte, CA, USA., Francis K; Clinical Trials Office, City of Hope National Medical Center, Duarte, CA, USA., Taplitz RA; Division of Infectious Diseases, City of Hope National Medical Center, Duarte, CA, USA.; Department of Medicine, City of Hope National Medical Center, Duarte, CA, USA., Dickter JK; Division of Infectious Diseases, City of Hope National Medical Center, Duarte, CA, USA.; Department of Medicine, City of Hope National Medical Center, Duarte, CA, USA., Dadwal S; Division of Infectious Diseases, City of Hope National Medical Center, Duarte, CA, USA.; Department of Medicine, City of Hope National Medical Center, Duarte, CA, USA., Puing AG; Division of Infectious Diseases, City of Hope National Medical Center, Duarte, CA, USA.; Department of Medicine, City of Hope National Medical Center, Duarte, CA, USA., Nanayakkara DD; Division of Infectious Diseases, City of Hope National Medical Center, Duarte, CA, USA.; Department of Medicine, City of Hope National Medical Center, Duarte, CA, USA., Ash P; Clinical Trials Office, City of Hope National Medical Center, Duarte, CA, USA.; Department of Medicine, City of Hope National Medical Center, Duarte, CA, USA., Cui Y; Department of Biostatistics, City of Hope National Medical Center, Duarte, CA, USA., Contreras H; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., La Rosa C; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Tiemann K; Translational Development Center, City of Hope National Medical Center, Duarte, CA, USA., Park Y; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Medina J; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Iniguez A; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Zhou Q; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Karpinski V; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Johnson D; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Faircloth K; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Kaltcheva T; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Nguyen J; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Kha M; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Nguyen VH; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Francisco SO; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Grifoni A; Division of Vaccine Discovery, La Jolla Institute for Immunology and University of California San Diego, La Jolla, CA, USA., Wong A; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Sette A; Division of Vaccine Discovery, La Jolla Institute for Immunology and University of California San Diego, La Jolla, CA, USA., Wussow F; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA., Diamond DJ; Department of Hematology and Hematopoietic Cell Transplantation and Hematologic Malignancies Research Institute, City of Hope National Medical Center, Duarte, CA, USA.

Publikováno v: The Lancet. Microbe [Lancet Microbe] 2022 Apr; Vol. 3 (4), pp. e252-e264. Date of Electronic Publication: 2022 Mar 09.