Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kalpita R. Karan"'
Autor:
Weichen Zhou, Kalpita R. Karan, Wenjin Gu, Hans-Ulrich Klein, Gabriel Sturm, Philip L. De Jager, David A. Bennett, Michio Hirano, Martin Picard, Ryan E. Mills
Publikováno v:
PLoS Biology, Vol 22, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/8dc4a1b8a8b649f6a70f4e4b765b8a7d
Autor:
Gabriel Sturm, Kalpita R. Karan, Anna S. Monzel, Balaji Santhanam, Tanja Taivassalo, Céline Bris, Sarah A. Ware, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J. McManus, Andres Cardenas, Jue Lin, Elissa S. Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G. Haller, Guy Lenaers, Douglas C. Wallace, Marie-Pierre St-Onge, Saeed Tavazoie, Vincent Procaccio, Brett A. Kaufman, Erin L. Seifert, Michio Hirano, Martin Picard
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-22 (2023)
A meta-analysis of 17 cohorts of mitochondrial disease patients reveals that OxPhos defects are associated with signs of hypermetabolism. Experiments in patient-derived fibroblast show that mitochondrial OxPhos defects trigger hypermetabolism in a ce
Externí odkaz:
https://doaj.org/article/8f3a6949c7834f1f9cf472f8feac04b2
Autor:
Gabriel Sturm, Anna S. Monzel, Kalpita R. Karan, Jeremy Michelson, Sarah A. Ware, Andres Cardenas, Jue Lin, Céline Bris, Balaji Santhanam, Michael P. Murphy, Morgan E. Levine, Steve Horvath, Daniel W. Belsky, Shuang Wang, Vincent Procaccio, Brett A. Kaufman, Michio Hirano, Martin Picard
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-19 (2022)
Measurement(s) gene expression assay • DNA Methylation • Telomere Length • Seahorse Bioenergetics • mtDNA copy number • Whole Genome Sequencing • Cytokine • cell-free DNA • mtDNA sequencing • cell-free GDF15 • cell-free IL6 Techno
Externí odkaz:
https://doaj.org/article/d6a7639344dc491583d7e15621e35c15
Autor:
Shannon Rausser, Caroline Trumpff, Marlon A McGill, Alex Junker, Wei Wang, Siu-Hong Ho, Anika Mitchell, Kalpita R Karan, Catherine Monk, Suzanne C Segerstrom, Rebecca G Reed, Martin Picard
Publikováno v:
eLife, Vol 10 (2021)
Using a high-throughput mitochondrial phenotyping platform to quantify multiple mitochondrial features among molecularly defined immune cell subtypes, we quantify the natural variation in mitochondrial DNA copy number (mtDNAcn), citrate synthase, and
Externí odkaz:
https://doaj.org/article/66750d7ee5894ea68f42b14e43507f68
Autor:
Kalpita R. Karan, Caroline Trumpff, Marissa Cross, Kristin M. Englestad, Anna L. Marsland, Peter McGuire, Michio Hirano, Martin Picard
Publikováno v:
J Mol Med (Berl)
Patients with oxidative phosphorylation (OxPhos) defects causing mitochondrial diseases appear particularly vulnerable to infections. Although OxPhos defects modulate cytokine production in vitro and in animal models, little is known about how circul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea621e0520ba19bb574282d09f0ac14
https://doi.org/10.1007/s00109-022-02206-2
https://doi.org/10.1007/s00109-022-02206-2
Autor:
Weichen Zhou, Kalpita R. Karan, Wenjin Gu, Hans-Ulrich Klein, Gabriel Sturm, Philip L. De Jager, David A. Bennett, Michio Hirano, Martin Picard, Ryan E Mills
Publikováno v:
bioRxiv
The transfer of mitochondrial DNA into the nuclear genomes of eukaryotes (Numts) has been linked to lifespan in non-human species1–3and recently demonstrated to occur in rare instances from one human generation to the next4. Here we investigated nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16179b92923f3a4097a1d67e513cebcb
https://doi.org/10.1101/2023.02.03.527065
https://doi.org/10.1101/2023.02.03.527065
Autor:
Caroline Trumpff, Shannon Rausser, Rachel Haahr, Kalpita R. Karan, Gilles Gouspillou, Eli Puterman, Clemens Kirschbaum, Martin Picard
Publikováno v:
Psychoneuroendocrinology
Mitochondria contain their own genome that can be released in multiple biofluids such as blood and cerebrospinal fluid, as cell-free mitochondrial DNA (cf-mtDNA). In clinical studies, blood cf-mtDNA predicts mortality and higher cf-mtDNA levels are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40356996171cb4a90336bb62ed7eb4b3
https://europepmc.org/articles/PMC9888586/
https://europepmc.org/articles/PMC9888586/
Autor:
Jeremy Michelson, Kalpita R Karan, Brett A. Kaufman, Gabriel Sturm, Caroline Trumpff, Martin Picard, Daniel Lindqvist, Dirk Moser, Claudia J. Lagranha, Johan Fernström, Veronica Taleon
Publikováno v:
Mitochondrion
Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to psychobiology. A systematic review of the literature reveals that blood cf-mtDNA varies in resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74aae41b3b2208e7076c352669bdc5ee
http://europepmc.org/articles/PMC8418815
http://europepmc.org/articles/PMC8418815
Autor:
Natalia Bobba-Alves, Gabriel Sturm, Jue Lin, Sarah A Ware, Kalpita R. Karan, Anna S. Monzel, Céline Bris, Vincent Procaccio, Guy Lenaers, Albert Higgins-Chen, Morgan Levine, Steve Horvath, Balaji S Santhanam, Brett A Kaufman, Michio Hirano, Elissa Epel, Martin Picard
Stress triggers anticipatory physiological responses that promote survival, a phenomenon termed allostasis. However, the chronic activation of energy-dependent allostatic responses results in allostatic load, a dysregulated state that predicts functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::105732f6ef54502dc166ff4b65a5f5d1
https://doi.org/10.1101/2022.02.22.481548
https://doi.org/10.1101/2022.02.22.481548
Autor:
Gabriel Sturm, Kalpita R Karan, Anna Monzel, Balaji S Santhanam, Tanja Taivassalo, Céline Bris, Sarah A Ware, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J McManus, Andres Cardenas, Jue Lin, Elissa S Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G Haller, Guy Lenaers, Douglas C Wallace, Marie-Pierre St-Onge, Saeed Tavazoie, Vincent Procaccio, Brett A Kaufman, Erin L Seifert, Michio Hirano, Martin Picard
Patients with primary mitochondrial diseases present with fatigue and multi-system disease, are often lean, and die prematurely, but the mechanistic basis for this clinical picture remains unclear. Integrating data from 17 cohorts of patients with mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d676cc902a2622d17050275451ae02d
https://doi.org/10.1101/2021.11.29.470428
https://doi.org/10.1101/2021.11.29.470428