Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Kalpana Patel"'
Autor:
Sandra Brosda, Lauren G. Aoude, Vanessa F. Bonazzi, Kalpana Patel, James M. Lonie, Clemence J. Belle, Felicity Newell, Lambros T. Koufariotis, Venkateswar Addala, Marjan M. Naeini, AGITG DOCTOR Investigators, John V. Pearson, Lutz Krause, Nicola Waddell, Andrew P. Barbour
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Oesophageal adenocarcinoma (OAC) is a highly heterogeneous cancer with poor survival. Standard curative treatment is chemotherapy with or without radiotherapy followed by oesophagectomy. Genomic heterogeneity is a feature of OAC a
Externí odkaz:
https://doaj.org/article/43ba55869131407abd9450bd4e269118
Autor:
Marjan M. Naeini, Felicity Newell, Lauren G. Aoude, Vanessa F. Bonazzi, Kalpana Patel, Guy Lampe, Lambros T. Koufariotis, Vanessa Lakis, Venkateswar Addala, Olga Kondrashova, Rebecca L. Johnston, Sowmya Sharma, Sandra Brosda, Oliver Holmes, Conrad Leonard, Scott Wood, Qinying Xu, Janine Thomas, Euan Walpole, G. Tao Mai, Stephen P. Ackland, Jarad Martin, Matthew Burge, Robert Finch, Christos S. Karapetis, Jenny Shannon, Louise Nott, Robert Bohmer, Kate Wilson, Elizabeth Barnes, John R. Zalcberg, B. Mark Smithers, John Simes, Timothy Price, Val Gebski, Katia Nones, David I. Watson, John V. Pearson, Andrew P. Barbour, Nicola Waddell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Oesophageal adenocarcinoma is a poor prognosis cancer and the molecular features underpinning response to treatment remain unclear. We investigate whole genome, transcriptomic and methylation data from 115 oesophageal adenocarcinoma patients
Externí odkaz:
https://doaj.org/article/10a795104a0f4275aaca1728299e2389
Autor:
James M. Lonie, Sandra Brosda, Vanessa F. Bonazzi, Lauren G. Aoude, Kalpana Patel, Ian Brown, Sowmya Sharma, Guy Lampe, Venkateswar Addala, Lambros T. Koufariotis, Scott Wood, Nicola Waddell, Riccardo Dolcetti, Andrew P. Barbour
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
A plateau in treatment effect can be seen for the current ‘one-size-fits-all’ approach to oesophageal adenocarcinoma (OAC) management using neoadjuvant chemoradiotherapy (nCRT) or chemotherapy (nCT). In OAC, the tumour microenvironment (TME) is l
Externí odkaz:
https://doaj.org/article/ec22afdcfa7d427aa2f5260f1b5f5596
Autor:
Jeffrey Molendijk, Cathryn M. Kolka, Henry Cairns, Sandra Brosda, Ahmed Mohamed, Alok K. Shah, Ian Brown, Mark P. Hodson, Thomas Hennessy, Guanghao Liu, Thomas Stoll, Renee S. Richards, Michael Gartside, Kalpana Patel, Nicholas J. Clemons, Wayne A. Phillips, Andrew Barbour, Johan A. Westerhuis, Michelle M. Hill
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Abstract Background The risk of esophageal adenocarcinoma (EAC) is associated with gastro‐esophageal reflux disease (GERD) and obesity. Lipid metabolism‐targeted therapies decrease the risk of progressing from Barrett's esophagus (BE) to EAC, but
Externí odkaz:
https://doaj.org/article/83267b7d1c744d739752ec479435fbf3
Autor:
Felicity Newell, Kalpana Patel, Michael Gartside, Lutz Krause, Sandra Brosda, Lauren G. Aoude, Kelly A. Loffler, Vanessa F. Bonazzi, Ann-Marie Patch, Stephen H. Kazakoff, Oliver Holmes, Qinying Xu, Scott Wood, Conrad Leonard, Guy Lampe, Reginald V. Lord, David C. Whiteman, John V. Pearson, Katia Nones, Nicola Waddell, Andrew P. Barbour
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-14 (2019)
Abstract Background Oesophageal adenocarcinoma (EAC) incidence is increasing and has a poor survival rate. Barrett’s oesophagus (BE) is a precursor condition that is associated with EAC and often occurs in conjunction with chronic gastro-oesophagea
Externí odkaz:
https://doaj.org/article/d3f969ebfdee44c79042fd747735c98a
Publikováno v:
Journal of Taibah University for Science, Vol 11, Iss 5, Pp 729-740 (2017)
Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for malaria. The present work aims to develop and validate a simple, accurate, precise and rapid ratio first order derivative spectrophotometric method for the si
Externí odkaz:
https://doaj.org/article/297ff1d0ea8844bbb0c817029bbd31c7
Publikováno v:
Journal of Taibah University for Science, Vol 11, Iss 1, Pp 121-132 (2017)
The present study examines simultaneous multiple response optimization using Derringer's desirability function for the development of an HPTLC method to detect Clonazepam and Paroxetine hydrochloride in pharmaceutical dosage form. Central composite d
Externí odkaz:
https://doaj.org/article/5e639d7030bb43d297c025d61d3ad093
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32386 (2012)
The inositol (1,4,5) trisphosphate 3-kinases comprise a family of enzymes (A, B, and C) that phosphorylate the calcium mobilising molecule inositol (1,4,5) trisphosphate (IP(3)) to generate inositol (1,3,4,5) tetrakisphosphate. This molecule can func
Externí odkaz:
https://doaj.org/article/9f0c330a81d847d09e083e7e5b943ac9
Autor:
Jennifer D Watkins, Nagadenahalli B Siddappa, Samir K Lakhashe, Michael Humbert, Anton Sholukh, Girish Hemashettar, Yin Ling Wong, John K Yoon, Wendy Wang, Francis J Novembre, Francois Villinger, Chris Ibegbu, Kalpana Patel, Davide Corti, Gloria Agatic, Fabrizia Vanzetta, Siro Bianchi, Jonathan L Heeney, Federica Sallusto, Antonio Lanzavecchia, Ruth M Ruprecht
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18207 (2011)
Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer cross-clade protection in viv
Externí odkaz:
https://doaj.org/article/18a1fa172f0a46cfb860a5bf3ee5b5cf
Publikováno v:
International Journal of Pharmaceutical Research And Allied Sciences. 12:17-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b977937104a9f97556d41e54878455b3
https://doi.org/10.51847/w70ezeztys
https://doi.org/10.51847/w70ezeztys