Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kalpana J Nattamai"'
Autor:
M Carolina Florian, Markus Klose, Mehmet Sacma, Jelena Jablanovic, Luke Knudson, Kalpana J Nattamai, Gina Marka, Angelika Vollmer, Karin Soller, Vadim Sakk, Nina Cabezas-Wallscheid, Yi Zheng, Medhanie A Mulaw, Ingmar Glauche, Hartmut Geiger
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2003389 (2018)
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is controlled by the activity of the small RhoGTPase cell division control prot
Externí odkaz:
https://doaj.org/article/edd84f3477ed491c831b529cfab0e5ea
Autor:
Andreas Brown, Desiree Schuetz, Yang Han, Deidre Daria, Kalpana J. Nattamai, Karina Eiwen, Vadim Sakk, Johannes Pospiech, Thomas Saller, Gary van Zant, Wolfgang Wagner, Hartmut Geiger
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/a8b73ebd065f46b89fa1a0c24c629585
Autor:
Kodandaramireddy Nalapareddy, Kalpana J. Nattamai, Rupali S. Kumar, Rebekah Karns, Kathryn A. Wikenheiser-Brokamp, Leesa L. Sampson, Maxime M. Mahe, Nambirajan Sundaram, Mary-Beth Yacyshyn, Bruce Yacyshyn, Michael A. Helmrath, Yi Zheng, Hartmut Geiger
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2608-2621 (2017)
Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number, and cell composition upon aging. Second, we identify a decline
Externí odkaz:
https://doaj.org/article/c6980a428dc64392a7a39bc4956b9d03
Autor:
Sachin Kumar, Jeffrey D Vassallo, Kalpana J Nattamai, Aishlin Hassan, Rebekah Karns, Angelika Vollmer, Karin Soller, Vadim Sakk, Mehmet Sacma, Travis Nemkov, Angelo D'Alessandro, Hartmut Geiger
Publikováno v:
EMBO reports. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55ace1faf8253303aa4a1a55a1c6a4a
https://doi.org/10.15252/embr.202255373
https://doi.org/10.15252/embr.202255373
Autor:
Chen Wang, Zhaowei Tu, Xiongwei Cai, Weinan Wang, Ashley Kuenzi Davis, Kalpana J Nattamai, Aditi Paranjpe, Phillip Dexheimer, Jianqiang Wu, L. Frank Huang, Hartmut Geiger, Gang Huang, Yi Zheng
Publikováno v:
Blood Advances.
As a member of the RUNT domain family core-binding transcription factors, RUNX1 is crucial for multiple stages of hematopoiesis and its mutation can cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). Previous wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70609746e332af2ff404b57714158468
https://doi.org/10.1182/bloodadvances.2022008591
https://doi.org/10.1182/bloodadvances.2022008591
Autor:
Ali Hageb, Torsten Thalheim, Kalpana J Nattamai, Bettina Möhrle, Mehmet Saçma, Vadim Sakk, Lars Thielecke, Kerstin Cornils, Carolin Grandy, Fabian Port, Kay-E Gottschalk, Jan-Philipp Mallm, Ingmar Glauche, Jörg Galle, Medhanie A Mulaw, Hartmut Geiger
Publikováno v:
Life Science Alliance. 5:e202201408
Upon aging, the function of the intestinal epithelium declines with a concomitant increase in aging-related diseases. ISCs play an important role in this process. It is known that ISC clonal dynamics follow a neutral drift model. However, it is not c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849a723ce6e132849a329c48aea8498f
https://doi.org/10.26508/lsa.202201408
https://doi.org/10.26508/lsa.202201408
Autor:
Maria Carolina, Florian, Hanna, Leins, Michael, Gobs, Yang, Han, Gina, Marka, Karin, Soller, Angelika, Vollmer, Vadim, Sakk, Kalpana J, Nattamai, Ahmad, Rayes, Xueheng, Zhao, Kenneth, Setchell, Medhanie, Mulaw, Wolfgang, Wagner, Yi, Zheng, Hartmut, Geiger
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Aging cell 19(9), e13208 (2020). doi:10.1111/acel.13208
Aging Cell
Universidad de Barcelona
Aging cell 19(9), e13208 (2020). doi:10.1111/acel.13208
Aging Cell
Cdc42 is a small RhoGTPase regulating multiple functions in eukaryotic cells. The activity of Cdc42 is significantly elevated in several tissues of aged mice, while the Cdc42 gain���of���activity mouse model presents with a premature agin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14529b9cae0e8e9b79cc6333c04b8040
Autor:
Sachin, Kumar, Kalpana J, Nattamai, Aishlin, Hassan, Amanda, Amoah, Rebekah, Karns, Cuiping, Zhang, Ying, Liang, Akiko, Shimamura, M Carolina, Florian, Ute, Bissels, Martha, Luevano, Andreas, Bosio, Stella M, Davies, Medhanie, Mulaw, Hartmut, Geiger, Kasiani C, Myers
Publikováno v:
Leukemia. 35(6)
Shwachman-Diamond syndrome (SDS) is a bone marrow failure (BMF) syndrome associated with an increased risk of myelodysplasia and leukemia. The molecular mechanisms of SDS are not fully understood. We report that primitive hematopoietic cells from SDS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb3e532d2617268e3050e04a48f2107d
https://pubmed.ncbi.nlm.nih.gov/33077869
https://pubmed.ncbi.nlm.nih.gov/33077869
Autor:
Andreas, Brown, Desiree, Schuetz, Yang, Han, Deidre, Daria, Kalpana J, Nattamai, Karina, Eiwen, Vadim, Sakk, Johannes, Pospiech, Thomas, Saller, Gary, van Zant, Wolfgang, Wagner, Hartmut, Geiger
Publikováno v:
Haematologica. 105(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::304d8be67d76408961e6cb3d647ecc39
https://pubmed.ncbi.nlm.nih.gov/32005650
https://pubmed.ncbi.nlm.nih.gov/32005650
Autor:
Thomas R. Kimball, Jo El J. Schultz, Sandra A. Witt, Lynne H. Liu, John N. Lorenz, Muthu Periasamy, Gary E. Shull, Betty J. Glascock, Michelle L. Nieman, Kalpana J. Nattamai
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 286:H1146-H1153
We recently developed a mouse model with a single functional allele of Serca2 ( Serca2+/–) that shows impaired cardiac contractility and relaxation without overt heart disease. The goal of this study was to test the hypothesis that chronic reductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa9aa2e97b184e69b9d8d19d279257d
https://doi.org/10.1152/ajpheart.00720.2003
https://doi.org/10.1152/ajpheart.00720.2003