Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kalpana, Parikh"'
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16545 (2011)
Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical
Externí odkaz:
https://doaj.org/article/3d4bc5b97eb745c5b8b85ffdefa4701c
Publikováno v:
Chemico-Biological Interactions. 203:191-195
Human liver prolidase, a metal-dependent dipeptidase, is being tested as a potential catalytic bioscavenger against organophosphorus (OP) chemical warfare nerve agents. The purpose of this study was to determine whether persistent and high-levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1fc2f4381936d527258d626d0f25d6
https://doi.org/10.1016/j.cbi.2012.08.021
https://doi.org/10.1016/j.cbi.2012.08.021
Autor:
Oksana Lockridge, Kalpana Parikh, Neil S. Jensen, Veeraswamy Manne, Ellen G. Duysen, Nageswararao Chilukuri, Benjamin Snow
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:92-101
Gene delivery using an adenoviral system has been effective in introducing therapeutic proteins in vitro and in vivo. This study tested the feasibility of using adenovirus to deliver clinically relevant amounts of butyrylcholinesterase (BChE), a prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f7281c1cd6e944f663340a2612a25b
https://doi.org/10.1124/jpet.110.175646
https://doi.org/10.1124/jpet.110.175646
Autor:
Wei Sun, Kalpana Parikh, Bhupendra P. Doctor, Lin Tang, Ashima Saxena, Nageswararao Chilukuri, Ramachandra S. Naik
Publikováno v:
Toxicology and Applied Pharmacology. 231:423-429
Human serum butyrylcholinesterase (Hu BChE) serves as an efficacious bioscavenger of highly toxic organophosphorus (OP) compounds. Since there is a concern that the supply of native Hu BChE may be limited, monomeric and tetrameric forms of recombinan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e42ecd551d25f9498fe21fd9419db8c
https://doi.org/10.1016/j.taap.2008.05.016
https://doi.org/10.1016/j.taap.2008.05.016
Autor:
Nageswararao Chilukuri, Kalpana Parikh, Ashima Saxena, Bhupendra P. Doctor, Ellen G. Duysen, Oksana Lockridge, Wei Sun
Publikováno v:
Chemico-Biological Interactions. 175:327-331
Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents, pesticide intoxication, and cocaine overdose. However, its widespread application is hampered by difficulties in large-scale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b0eb99a5998c2334298c878fc6ba56
https://doi.org/10.1016/j.cbi.2008.04.009
https://doi.org/10.1016/j.cbi.2008.04.009
Autor:
Wei Sun, Nageswararao Chilukuri, Ramachandra S. Naik, Lin Tang, Kalpana Parikh, Bhupendra P. Doctor, Ashima Saxena
Publikováno v:
Chemico-Biological Interactions. 175:255-260
The therapeutic value of human serum butyrylcholinesterase (Hu BChE) as a bioscavenger of chemical warfare agents is due to its high reactivity with organophosphorus compounds and prolonged circulatory stability. Native Hu BChE is mostly tetrameric i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8289cd2a298169bbddd6bfd58e859cc3
https://doi.org/10.1016/j.cbi.2008.05.020
https://doi.org/10.1016/j.cbi.2008.05.020
Autor:
Stephen Anderson, Kalpana Parikh, Guang Lan, Steven R. Head, Michael T. Boyce-Jacino, Yu-Hui Rogers, Philip Goelet
Publikováno v:
Nucleic Acids Research. 25:5065-5071
There is a growing and significant demand for reliable, simple and sensitive methods for repeated scanning of a given gene or gene fragment for detection and characterization of mutations. Solid-phase sequencing by single base primer extension of nes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9578a79b0b07695464eb6abc6a341174
https://doi.org/10.1093/nar/25.24.5065
https://doi.org/10.1093/nar/25.24.5065
Autor:
Ellen G. Duysen, Veeraswamy Manne, Oksana Lockridge, Kalpana Parikh, Nageswararao Chilukuri, Vineela Aleti
Publikováno v:
Gene therapy. 18(3)
Human paraoxonase1 (hPON1) is a potential therapeutic against the toxicity of organophosphorus (OP) pesticides and chemical warfare nerve agents. We tested whether PON1 gene transfer using adenovirus provides protection against the toxicity of the OP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d432210fd1ae9df5bb2f09fb4ffc7433
https://pubmed.ncbi.nlm.nih.gov/20981111
https://pubmed.ncbi.nlm.nih.gov/20981111
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e16545 (2011)
PLoS ONE, Vol 6, Iss 2, p e16545 (2011)
Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf39ee80831363758dfc2a0d5adb749a
https://pubmed.ncbi.nlm.nih.gov/21347421
https://pubmed.ncbi.nlm.nih.gov/21347421
Autor:
Oksana Lockridge, Nageswararao Chilukuri, Robert C. diTargiani, Ellen G. Duysen, Ashima Saxena, Kalpana Parikh, Bhupendra P. Doctor
Publikováno v:
Molecular pharmacology. 76(3)
Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents. We have showed previously that recombinant (r) Hu BChE can be expressed at very high levels, 400 to 600 U/ml in mouse blood,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c36b3dc25cb58ed164dd464e0827643
https://pubmed.ncbi.nlm.nih.gov/19542320
https://pubmed.ncbi.nlm.nih.gov/19542320