Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kalman Somogyi"'
Autor:
Alicia Alonso de la Vega, Nuri Alpay Temiz, Rafail Tasakis, Kalman Somogyi, Lorena Salgueiro, Eleni Zimmer, Maria Ramos, Alberto Diaz-Jimenez, Sara Chocarro, Mirian Fernández-Vaquero, Bojana Stefanovska, Eli Reuveni, Uri Ben-David, Albrecht Stenzinger, Tanja Poth, Mathias Heikenwälder, Nina Papavasiliou, Reuben S. Harris, Rocio Sotillo
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background RNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The cytosine deaminase APOBEC3B is implicated in tumor evolution through DNA mutation, but whet
Externí odkaz:
https://doaj.org/article/4370126016334153b5ad7b9bf80e0892
Autor:
Fan Pan, Sara Chocarro, Maria Ramos, Yuanyuan Chen, Alicia Alonso de la Vega, Kalman Somogyi, Rocio Sotillo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-17 (2023)
Abstract Tumor progression and evolution are frequently associated with chromosomal instability (CIN). Tumor cells often express high levels of the mitotic checkpoint protein MAD2, leading to mitotic arrest and cell death. However, some tumor cells a
Externí odkaz:
https://doaj.org/article/2a0c754eb2cc466ba280dc86cbb669e4
Autor:
Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres, Rocío Sotillo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
PLK1 is a mitotic regulator overexpressed in cancer; however, whether this overexpression causally contributes to tumor development is unclear. Here the authors produce an inducible mouse model to overexpress PLK1 and show that actually this can act
Externí odkaz:
https://doaj.org/article/624e442f805148c5bac60f63e764f010
Publikováno v:
Cancers, Vol 13, Iss 23, p 6027 (2021)
Aneuploidy, an imbalance number of chromosomes, is frequently observed in lung cancer and inversely correlates with patient survival. Paradoxically, an aneuploid karyotype has detrimental consequences on cellular fitness, and it has been proposed tha
Externí odkaz:
https://doaj.org/article/0ee6f6bff3974e55a8f668dec510a176
Autor:
Lorena Salgueiro, Christopher Buccitelli, Konstantina Rowald, Kalman Somogyi, Sridhar Kandala, Jan O Korbel, Rocio Sotillo
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Abstract Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using
Externí odkaz:
https://doaj.org/article/225029ac68f7435d9344bd21f7538671
Autor:
Nicole Staudt, Andreas Molitor, Kalman Somogyi, Juan Mata, Silvia Curado, Karsten Eulenberg, Martin Meise, Thomas Siegmund, Thomas Häder, Andres Hilfiker, Günter Brönner, Anne Ephrussi, Pernille Rørth, Stephen M Cohen, Sonja Fellert, Ho-Ryun Chung, Olaf Piepenburg, Ulrich Schäfer, Herbert Jäckle, Gerd Vorbrüggen
Publikováno v:
PLoS Genetics, Vol 1, Iss 4, p e55 (2005)
This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes that affect embryonic muscle pattern formation. We
Externí odkaz:
https://doaj.org/article/f5c7e34245a2436dad6052c0874e4f95
Autor:
Alicia Alonso de la Vega, Nuri Temiz, Rafail Tasakis, Kalman Somogyi, Eli Reuveni, Uri Ben-David, Albrecht Stenzinger, Tanja Poth, Fotini Papavasiliou, Reuben Harris, Rocio Sotillo
RNA editing has been described to promote heterogeneity leading to the development of multiple disorders including cancer. The cytosine deaminase APOBEC3B is known to fuel tumor evolution through DNA mutagenesis, but whether it may also function as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8f699a8743a4fbe80f6e17ad3a4b05
https://doi.org/10.21203/rs.3.rs-1715047/v1
https://doi.org/10.21203/rs.3.rs-1715047/v1
Publikováno v:
Cancers, Vol 13, Iss 6027, p 6027 (2021)
Cancers; Volume 13; Issue 23; Pages: 6027
Cancers
Cancers; Volume 13; Issue 23; Pages: 6027
Cancers
Simple Summary In tissue homeostasis, aneuploid cells have been suggested to be recognized and eliminated by immune cells. However, these initiating cancer cells can evade the immune system and ultimately derivate a tumor. To better understand how an
Autor:
Anne-Sophie Lamort, Jan Christian Kaiser, Mario A.A. Pepe, Ioannis Lilis, Giannoula Ntaliarda, Kalman Somogyi, Magda Spella, Sabine J. Behrend, Georgia A. Giotopoulou, Willem Kujawa, Michael Lindner, Ina Koch, Rudolf A. Hatz, Juergen Behr, Rocio Sotillo, Andrea C. Schamberger, Georgios T. Stathopoulos
Publikováno v:
Eur. Respir. J. 60:2101674 (2021)
BackgroundSurvival after curative resection of early-stage lung adenocarcinoma (LUAD) varies and prognostic biomarkers are urgently needed.MethodsLarge-format tissue samples from a prospective cohort of 200 patients with resected LUAD were immunophen
Autor:
Kalman Somogyi, Konstantina Rowald, Christopher Buccitelli, Jan O. Korbel, Lorena Salgueiro, Rocio Sotillo, Sridhar Kandala
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 3, Pp n/a-n/a (2020)
Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear. Using a CIN mo