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Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.

Autor: Amare AT; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia. azmeraw.amare@adelaide.edu.au., Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, UNSW Medicine & Health, University of New South Wales, Sydney, Australia., Schubert KO; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.; Northern Adelaide Local Health Network, Mental Health Services, Adelaide, SA, Australia., Fullerton JM; Neuroscience Research Australia, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Ahmed M; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia., Hartmann S; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Degenhardt F; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR Klinikum Essen, University of Duisburg-Essen, Rheinische Kliniken, Essen, Germany., Tekola-Ayele F; Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA., Hou L; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Hsu YH; HSL Institute for Aging Research, Harvard Medical School, Boston, MA, USA.; Program for Quantitative Genomics, Harvard School of Public Health, Boston, MA, USA., Shekhtman T; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Adli M; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany., Akula N; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Akiyama K; Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan., Ardau R; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy., Arias B; Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Barcelona, Spain., Aubry JM; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland., Hasler R; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland., Richard-Lepouriel H; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland., Perroud N; Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland., Backlund L; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Bhattacharjee AK; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Bellivier F; INSERM UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France., Benabarre A; Bipolar and Depressive Disorders Program,, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Bengesser S; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Birner A; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria., Marie-Claire C; INSERM UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.; Université Paris Cité, Inserm, Optimisation Thérapeutique en Neuropsychopharmacologie, F-75006, Paris, France., Cervantes P; The Neuromodulation Unit, McGill University Health Centre, Montreal, Canada., Chen HC; Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan., Chillotti C; Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy., Cichon S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University Hospital Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany., Cruceanu C; Douglas Mental Health University Institute, McGill University, Montreal, Canada., Czerski PM; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland., Dalkner N; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria., Del Zompo M; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., DePaulo JR; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Étain B; INSERM UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France., Jamain S; Inserm U955, Translational Psychiatry laboratory, Fondation FondaMental, Créteil, France., Falkai P; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Max Planck Institute of Psychiatry, Munich, Germany., Forstner AJ; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany., Frisen L; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Frye MA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Gard S; Pôle de Psychiatrie Générale Universitaire, Hôpital Charles Perrens, Bordeaux, France., Garnham JS; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Goes FS; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Grigoroiu-Serbanescu M; Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania., Fallgatter AJ; University Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tuebingen, Germany., Stegmaier S; Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany., Ethofer T; Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany.; Department of Biomedical Resonance, University of Tuebingen, Tuebingen, Germany., Biere S; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Petrova K; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Schuster C; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Adorjan K; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Heilbronner M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Kohshour MO; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Schaupp SK; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Schulte EC; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany., Vogl T; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Anghelescu IG; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, Germany., Arolt V; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Dietrich D; AMEOS Clinical Center Hildesheim, Hildesheim, Germany.; Center for Systems Neuroscience (ZSN), Hannover, Germany., Figge C; Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, 26160, Germany., Jäger M; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany., Lang FU; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany., Juckel G; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany., Konrad C; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany., Reimer J; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Psychiatry, Health North Hospital Group, Bremen, Germany., Schmauß M; Department of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Schmitt A; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, São Paulo, Brazil., Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany., von Hagen M; Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Zimmermann J; Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany., Andlauer TFM; Department of Neurology, University Hospital rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Fischer A; German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Bermpohl F; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany., Ritter P; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Matura S; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany., Gryaznova A; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Falkenberg I; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Yildiz C; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Kircher T; Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany., Schmidt J; Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany., Koch M; Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany., Gade K; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Trost S; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Haussleiter IS; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany., Lambert M; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rohenkohl AC; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kraft V; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Grof P; Mood Disorders Center of Ottawa, Ontario, Canada., Hashimoto R; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8553, Japan., Hauser J; Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland., Herms S; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University Hospital Basel, Basel, Switzerland., Hoffmann P; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.; Department of Biomedicine, University Hospital Basel, Basel, Switzerland., Jiménez E; Bipolar and Depressive Disorders Program,, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Kahn JP; Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France., Kassem L; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Kuo PH; Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Kato T; Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan., Kelsoe J; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Kittel-Schneider S; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Würzburg, Wurzburg, Germany., Ferensztajn-Rochowiak E; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., König B; Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria., Kusumi I; Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan., Laje G; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Landén M; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lavebratt C; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Leboyer M; Inserm U955, Translational Psychiatry laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France., Leckband SG; Office of Mental Health, VA San Diego Healthcare System, San Diego, CA, USA., Tortorella A; Department of Psychiatry, University of Perugia, Perugia, Italy., Manchia M; Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada., Martinsson L; Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden., McCarthy MJ; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.; Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA., McElroy S; Department of Psychiatry, Lindner Center of Hope / University of Cincinnati, Mason, OH, USA., Colom F; Mental Health Research Group, IMIM-Hospital del Mar, Barcelona, Catalonia, Spain.; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain., Millischer V; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria., Mitjans M; Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.; Centro de Investigación Biomédica en Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain., Mondimore FM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Monteleone P; Neurosciences Section, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy.; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy., Nievergelt CM; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Novák T; National Institute of Mental Health, Klecany, Czech Republic., O'Donovan C; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Ozaki N; Department of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Pisanu C; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Potash JB; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany., Reininghaus E; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada., Rybakowski JK; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland., Schalling M; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Schofield PR; Neuroscience Research Australia, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Schweizer BW; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Severino G; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Shilling PD; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Shimoda K; Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan., Simhandl C; Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria., Slaney CM; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Squassina A; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Stamm T; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.; Department of Clinical Psychiatry and Psychotherapy, Brandenburg Medical School, Brandenburg, Germany., Stopkova P; National Institute of Mental Health, Klecany, Czech Republic., Maj M; Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy., Turecki G; Douglas Mental Health University Institute, McGill University, Montreal, Canada., Vieta E; Bipolar and Depressive Disorders Program,, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., Veeh J; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Wright A; School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia., Zandi PP; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Mitchell PB; School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany., Alda M; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; National Institute of Mental Health, Klecany, Czech Republic., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., McMahon FJ; Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Norton College of Medicine, Syracuse, NY, USA., Clark SR; Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia., Baune BT; Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Parkville, VIC, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2023 Dec; Vol. 28 (12), pp. 5251-5261. Date of Electronic Publication: 2023 Jul 11.

Common genetic variants contribute to heritability of age at onset of schizophrenia.

Autor: Sada-Fuente E; Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili (IISPV), Department of Psychiatry, Universitat Rovira i Virgili (URV), Reus, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Aranda S; Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili (IISPV), Department of Psychiatry, Universitat Rovira i Virgili (URV), Reus, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, 80336, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, 80336, Munich, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, 80336, Munich, Germany., Moltó MD; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Genetics, Universitat de Valencia, 46100, Valencia, Spain.; Biomedical Research Institute INCLIVA, 46010, Valencia, Spain., Aguilar EJ; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Biomedical Research Institute INCLIVA, 46010, Valencia, Spain.; Department of Psychiatry, Hospital Clínico Universitario de Valencia, 46010, Valencia, Spain.; Faculty of Medicine, Universidad de Valencia, 46010, Valencia, Spain., González-Peñas J; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Universitario Gregorio Marañón, 28007, Madrid, Spain., Andreu-Bernabeu Á; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Universitario Gregorio Marañón, 28007, Madrid, Spain.; Faculty of Medicine, Universidad Complutense, 28007, Madrid, Spain., Arango C; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Universitario Gregorio Marañón, 28007, Madrid, Spain.; Faculty of Medicine, Universidad Complutense, 28007, Madrid, Spain., Crespo-Facorro B; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Universidad de Cantabria, 39005, Santander, Cantabria, Spain.; Hospital Universitario Marqués de Valdecilla-IDIVAL, 39008, Santander, Cantabria, Spain.; Department of Psychiatry, University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain., González-Pinto A; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Psychiatry, Hospital Universitario Araba, Instituto de Investigación Sanitaria Bioaraba, Universidad del País Vasco, 01009, Vitoria, Spain., Fañanás L; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028, Barcelona, Spain., Arias B; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028, Barcelona, Spain., Bobes J; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.; Faculty of Medicine and Health Sciences - Psychiatry, Universidad de Oviedo, 33006, Oviedo, Spain.; Mental Health Services of Principado de Asturias (SESPA), Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain.; Instituto de Neurociencias del Principado de Asturias (INEUROPA), 33003, Oviedo, Spain., Costas J; Psychiatric Genetics Group, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Servizo Galego de Saúde (SERGAS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), 15706, Santiago de Compostela, Spain., Martorell L; Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili (IISPV), Department of Psychiatry, Universitat Rovira i Virgili (URV), Reus, Spain.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, 80336, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, 80336, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, US., Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig Maximilian University of Munich, 80336, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, 80336, Munich, Germany., Vilella E; Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili (IISPV), Department of Psychiatry, Universitat Rovira i Virgili (URV), Reus, Spain. vilellae@peremata.com.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. vilellae@peremata.com., Muntané G; Hospital Universitari Institut Pere Mata, Institut d'Investigació Sanitària Pere Virgili (IISPV), Department of Psychiatry, Universitat Rovira i Virgili (URV), Reus, Spain. muntaneg@peremata.com.; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. muntaneg@peremata.com.; Institut de Biologia Evolutiva (UPF-CSIC), Departament de Medicina i Ciències de la Vida, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain. muntaneg@peremata.com.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2023 Jun 13; Vol. 13 (1), pp. 201. Date of Electronic Publication: 2023 Jun 13.

Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study.

Autor: Senner F; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany.; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Hiendl L; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of Graz, Graz, 8036, Austria., Bengesser S; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of Graz, Graz, 8036, Austria. susanne.bengesser@medunigraz.at., Adorjan K; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany.; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Anghelescu IG; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, 14050, Germany., Baune BT; Department of Psychiatry, University of Münster, Münster, 48149, Germany.; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia., Budde M; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, 48149, Germany., Dietrich DE; AMEOS Clinical Center Hildesheim, Hildesheim, 31135, Germany.; Center for Systems Neuroscience (ZSN), Hannover, 30559, Germany.; Department of Psychiatry, Medical School of Hannover, Hannover, 30625, Germany., Falkai P; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany., Fallgatter AJ; Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, 72076, Germany., Hasan A; Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, University of Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, 86156, Germany., Heilbronner M; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Jäger M; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, 89312, Germany., Juckel G; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, 44791, Germany., Kalman JL; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany.; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Konrad C; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, 27356, Germany., Kohshour MO; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Papiol S; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany.; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Reimer J; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.; Department of Psychiatry, Health North Hospital Group, Bremen, 28102, Germany., Schaupp SK; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Schmauß M; Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, University of Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, 86156, Germany., Senner S; Center for Psychiatry Reichenau, Academic Hospital University of Konstanz, Konstanz, 78479, Germany., Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, 18147, Germany., Vogl T; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Zimmermann J; Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, 26160, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany., Schulte EC; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany.; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Medical Faculty, University of Bonn, Bonn, 53105, Germany.; Institute of Human Genetics, University Hospital Bonn, Medical Faculty, University of Bonn, Bonn, 53127, Germany., Schulze TG; Institute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, 80336, Germany.; Department of Psychiatry and Behavorial Sciences, SUNY Upstate Medical University, Syracuse, 54, NY, USA., Reininghaus EZ; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of Graz, Graz, 8036, Austria., Kirchner SK; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, 80336, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, University of Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, 86156, Germany., Dalkner N; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of Graz, Graz, 8036, Austria.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2023 Mar 25; Vol. 13 (1), pp. 99. Date of Electronic Publication: 2023 Mar 25.

Lipid Alteration Signature in the Blood Plasma of Individuals With Schizophrenia, Depression, and Bipolar Disorder.

Autor: Tkachev A; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia.; Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia., Stekolshchikova E; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia., Vanyushkina A; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia., Zhang H; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Morozova A; Department Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia.; Moscow Psychiatric Hospital No. 1, named after N.A. Alekseev, Moscow, Russia., Zozulya S; Mental Health Research Center, Moscow, Russia., Kurochkin I; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia., Anikanov N; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia., Egorova A; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia., Yushina E; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia.; FSBSI N.P. Bochkov Research Center of Medical Genetics, Moscow, Russia., Vogl T; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Senner F; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Schaupp SK; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Papiol S; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Kohshour MO; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Klöhn-Saghatolislam F; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Kalman JL; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Heilbronner U; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Heilbronner M; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Gade K; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Comes AL; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Budde M; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Anderson-Schmidt H; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Adorjan K; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; German Center for Neurodegenerative Diseases, Göttingen, Germany.; Neurosciences and Signaling Group, Institute of Medicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Reininghaus EZ; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of Graz, Graz, Austria., Juckel G; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Fallgatter A; Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University Tübingen, Tübingen, Germany., Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany., Schmauß M; Department of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany., von Hagen M; Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany., Zorkina Y; Department Basic and Applied Neurobiology, V. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Moscow, Russia.; Moscow Psychiatric Hospital No. 1, named after N.A. Alekseev, Moscow, Russia., Reznik A; Moscow Psychiatric Hospital No. 1, named after N.A. Alekseev, Moscow, Russia.; Moscow State University of Food Production, Moscow, Russia., Barkhatova A; Mental Health Research Center, Moscow, Russia., Lisov R; Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia.; Moscow Institute of Physics and Technology, Dolgoprudny, Russia., Mokrov N; Moscow Institute of Physics and Technology, Dolgoprudny, Russia.; Center for Artificial Intelligence Technologies, Skolkovo Institute of Science and Technology, Moscow, Russia., Panov M; Technology Innovation Institute, Abu Dhabi, United Arab Emirates., Zubkov D; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia., Petrova D; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia., Zhou C; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China., Liu Y; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Pu J; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Falkai P; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany., Kostyuk G; Moscow Psychiatric Hospital No. 1, named after N.A. Alekseev, Moscow, Russia., Klyushnik T; Mental Health Research Center, Moscow, Russia., Schulze TG; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland., Xie P; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurobiology, Chongqing, China., Schulte EC; Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital Bonn, medical Faculty University of Bonn, Bonn, Germany., Khaitovich P; Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia.

Publikováno v: JAMA psychiatry [JAMA Psychiatry] 2023 Mar 01; Vol. 80 (3), pp. 250-259.