Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kallirroi Kefala"'
Autor:
Kate E. Templeton, Helen Wise, Elizabeth Wastnedge, Thomas C. Williams, Ramya Bhatia, Gina McAllister, Kallirroi Kefala, Kate Cuschieri, Ingólfur Johannessen, Fiona Hamilton, Jill Shepherd, Ian F. Laurenson, Donald Waters, Alistair Stewart
Publikováno v:
Wellcome Open Research, Vol 5 (2022)
Background: This study aimed to determine the sensitivity and specificity of reverse transcription PCR (RT-PCR) testing of upper respiratory tract samples from hospitalised patients with coronavirus disease 2019 (COVID-19), compared to the gold stand
Externí odkaz:
https://doaj.org/article/ad2170bab63b4062b69dd085a5b797fe
Autor:
Jesús Villar, Gerald Lebovic, Paolo Pelosi, Arthur S. Slutsky, David Gattas, Maureen O. Meade, Karen E. A. Burns, Deborah J. Cook, Scott K. Epstein, Leena Rizvi, Peter Dodek, Farhad N Kapadia, Andrew Jones, Kallirroi Kefala
Publikováno v:
JAMA. 325(12)
Importance Although most critically ill patients receive invasive mechanical ventilation (IMV), few studies have characterized how IMV is discontinued in practice. Objective To describe practice variation in IMV discontinuation internationally, assoc
Autor:
Christopher Bassford, Tina Van Den Broeck, Gert Boschman, Bryan Yates, A. John Simpson, Vanessa Linnett, Niall Anderson, Daniel F. McAuley, Jonathan Hulme, Jennie Parker, Cecilia M O'Kane, Gavin D. Perkins, Julian Sonksen, Anthony J. Rostron, Glenn Phair, Ashley Agus, Bronagh Blackwood, Suveer Singh, Lydia M Emerson, Kallirroi Kefala, D W James Keenan, Alistair I Roy, Ronan McMullan, Shondipon Laha, Timothy S. Walsh, Stephen Bonner, Nicole M Robin, Simon Baudouin, Paul Dark, Susan A Bowett, Ingeborg Welters, Ross L Paterson, Craig Spencer, Jonathan Scott, A Joy Allen, Jonathan Bannard-Smith, Thomas P Hellyer, Andrew Conway Morris, Stephen E Wright
Publikováno v:
Hellyer, T P, McAuley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, D W J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' More research is required to understand factors influencing antibiotic prescribing in complex conditions like suspected ventilator-associated pneumonia ', Annals of Translational Medicine, vol. 8, no. 13, pp. 840 . https://doi.org/10.21037/atm-20-3701
Ann Transl Med
ANNALS OF TRANSLATIONAL MEDICINE
Ann Transl Med
ANNALS OF TRANSLATIONAL MEDICINE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f0c723a63b6a59126a0f7be7f8a2cf
https://pure.qub.ac.uk/en/publications/more-research-is-required-to-understand-factors-influencing-antibiotic-prescribing-in-complex-conditions-like-suspected-ventilatorassociated-pneumonia(564316aa-c89d-4960-b344-374989c640ea).html
https://pure.qub.ac.uk/en/publications/more-research-is-required-to-understand-factors-influencing-antibiotic-prescribing-in-complex-conditions-like-suspected-ventilatorassociated-pneumonia(564316aa-c89d-4960-b344-374989c640ea).html
Autor:
Jill Shepherd, Alistair Stewart, Kallirroi Kefala, Fiona Hamilton, Ramya Bhatia, Donald Waters, Ingolfur Johannessen, Elizabeth Wastnedge, Ian F. Laurenson, Helen Wise, Thomas C Williams, Gina McAllister, Kate Cuschieri, Kate Templeton
Publikováno v:
Williams, T C, Wastnedge, E, Mcallister, G, Bhatia, R, Cuschieri, K, Kefala, K, Hamilton, F, Johannessen, I, Laurenson, I F, Shepherd, J, Stewart, A, Waters, D, Wise, H & Templeton, K E 2020, ' Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort study ', Wellcome Open Research, vol. 5, pp. 254 . https://doi.org/10.12688/wellcomeopenres.16342.1
Background: This study aimed to determine the sensitivity and specificity of reverse transcription PCR (RT-PCR) testing of upper respiratory tract samples from hospitalised patients with coronavirus disease 2019 (COVID-19), compared to the gold stand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00675bf9fa5451d2cb68cdb9a5014ed
Autor:
J. McCoubrey, Esther Grant, Odette Brooks, Kallirroi Kefala, Thomas H. Craven, Timothy S. Walsh, Jacqui Reilly, Ian F. Laurenson, Gosha Wojcik, Sean Keating
Publikováno v:
Craven, T H, Wojcik, G, Mccoubrey, J, Brooks, O, Grant, E, Keating, S, Reilly, J, Laurenson, I F, Kefala, K & Walsh, T S 2020, ' Ventilator-associated pneumonia surveillance using two methods ', Journal of Hospital Infection . https://doi.org/10.1016/j.jhin.2020.01.020
BackgroundVentilator-associated pneumonia surveillance is used as a quality indicator due to concerns that some cases may be preventable and may contribute to mortality. Various surveillance criteria exist for the purposes of national reporting, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7762c8a285fa623ab036a0d08ee43200
https://hdl.handle.net/20.500.11820/cd12ea32-5a13-46bd-82e6-240a8a9efc93
https://hdl.handle.net/20.500.11820/cd12ea32-5a13-46bd-82e6-240a8a9efc93
Autor:
D W James Keenan, Alistair I Roy, Ronan McMullan, Ashley Agus, Niall Anderson, Gert Boschman, Christopher Bassford, Stephen E Wright, Jonathan Scott, Anthony J. Rostron, A. John Simpson, Nicole M Robin, Cecilia O'Kane, Vanessa Linnett, Simon Baudouin, Ingeborg Welters, Jonathan Hulme, Susan A Bowett, Glenn Phair, Lydia M Emerson, Daniel F. McAuley, A Joy Allen, Julian Sonksen, Bronagh Blackwood, Paul Dark, Ross L Paterson, Kallirroi Kefala, Stephen Bonner, Gavin D. Perkins, Bryan Yates, Tina Van Den Broeck, Jennie Parker, Shondipon Laha, Timothy S. Walsh, Craig Spencer, Thomas P Hellyer, Suveer Singh, Jonathan Bannard-Smith, Andrew Conway Morris
Publikováno v:
LANCET RESPIRATORY MEDICINE
Hellyer, T P, Mcauley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, Mcmullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, D J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine . https://doi.org/10.1016/S2213-2600(19)30367-4
Ann Transl Med
Hellyer, T P, McAuley, D, Walsh, T S, Anderson, N H, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C, Baudouin, S V, Paterson, R W, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N, Welters, I, Bassford, C, Yates, B, Spencer, C, Laha, S, Hulme, J, Bonner, S, Linnett, V C, Sonksen, J, van den Broeck, T, Boschman, G, Keenan, J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2019, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182 . https://doi.org/10.1016/S2213-2600(19)30367-4
Hellyer, T P, McAuley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, DW J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182-191 . https://doi.org/10.1016/S2213-2600(19)30367-4
Hellyer, T P, Mcauley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, Mcmullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, D J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine . https://doi.org/10.1016/S2213-2600(19)30367-4
Ann Transl Med
Hellyer, T P, McAuley, D, Walsh, T S, Anderson, N H, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C, Baudouin, S V, Paterson, R W, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N, Welters, I, Bassford, C, Yates, B, Spencer, C, Laha, S, Hulme, J, Bonner, S, Linnett, V C, Sonksen, J, van den Broeck, T, Boschman, G, Keenan, J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2019, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182 . https://doi.org/10.1016/S2213-2600(19)30367-4
Hellyer, T P, McAuley, D F, Walsh, T S, Anderson, N, Conway Morris, A, Singh, S, Dark, P, Roy, A I, Perkins, G D, McMullan, R, Emerson, L M, Blackwood, B, Wright, S E, Kefala, K, O'Kane, C M, Baudouin, S V, Paterson, R L, Rostron, A J, Agus, A, Bannard-Smith, J, Robin, N M, Welters, I D, Bassford, C, Yates, B, Spencer, C, Laha, S K, Hulme, J, Bonner, S, Linnett, V, Sonksen, J, Van Den Broeck, T, Boschman, G, Keenan, DW J, Scott, J, Allen, A J, Phair, G, Parker, J, Bowett, S A & Simpson, A J 2020, ' Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation ', The Lancet Respiratory Medicine, vol. 8, no. 2, pp. 182-191 . https://doi.org/10.1016/S2213-2600(19)30367-4
Background: Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations of IL-1β and IL-8 in bronchoalveolar lavage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0819679fdb81603ef968776dfb2fb3b4
http://hdl.handle.net/10044/1/82700
http://hdl.handle.net/10044/1/82700
Autor:
Natalie Mitchell, Vanessa Quinn, Keith Couper, Jean Antonelli, Lia McNamee, Janice Montgomery, Akesh Dhrampal, Alison Hall, Ronald Carrera, Henrik Reschreiter, Samantha Hendry, Stephen T. Webb, Maurizio Cecconi, Teresa Melody, Jonathan Hackett, Emer Neau, Peter Hampshire, Sarah Hierons, Gareth Sellors, Zoe Beardow, Ron Daniels, Pratik Sinha, Colette Seasman, Dawn Kelly, Carolyn S. Calfee, Katarzyna Zamoscik, Mike Gillies, Chris Smalley, Fiona Wade-Smith, Stephen G. Ward, Carole Schilling, Alexander Binning, Cecilia O'Kane, Kulwant Dhadwal, Timothy S. Walsh, Laura Youds, Lisa Sleight, Clair Harris, Pam Ramsay, Aisling Clarkson, Stephen Drage, Amy McInerney, Murthy Buddhavarapu, Kirsty Everingham, J A Wood, Daniel Martin, Kayla Harris, Corrienne McCulloch, Cliona McDowell, Griania White, Dorothy Breen, Julie Dawson, David Rogerson, Luigi Camporota, Kallirroi Kefala, John G Laffey, Brian Marsh, Archana Paikray, Lynn Gilfeather, Andrew Burtenshaw, Kevin L. Delucchi, Kate McGuigan, David Hope, Syed Farjad Sultan, Abby Brown, Sinead O'Kane, Melissa Rosbergen, Paula Meale, Daniel F. McAuley, Anna Walker, Julie Patrick-Heselton, Noel Hemmings, Sarah James, Arlo Whitehouse, Willis J Peel, Michael A. Matthay, Louise Boardman, Julie Wollaston, John G. Laffey, Sundeep Kaul, Andrew Gratrix, Paul Jefferson, Ged Dempsey, David Shaw, Alistair Nichol, Daniel Hadfield, Veronica McInerney, Ingeborg Welters, Katie Sweet, Samantha Hagan, Conor Bentley, Karen Williams, Tom Trinick, Manu Shankar-Hari, Heidi Dawson, Andrew Johnston, Stephen Graystone, Daniel McAuley, Banwari Agarwal, Julie Camsooksai, Victoria Martinson, Catherine Jardine, Andrew R Bodenham, Prashast Prashast, James O'Rourke, Clare Mellis, Fang Gao, Craig Morris, Neil Young, Steven Henderson, Victoria Waugh, Christopher Danbury, Yongyan Qui, Georgina Parsons, Catherine Leonard, Neil Smith, Timothy Gould, Molly Chibvuri, Nicola Jacques, Sinead Helyar, Matthew Thomas, Sarah Casboult, Lukas Pokorny, Alan Davidson, Naomi Hickey, Rachael Bennett, Joanne Thompson, Orla O'Neill, Elizabeth Lemon, Paul Johnston, Cat Yates, John Trinder, Gavin Nicol, Jacqueline Baldwin, Johannes Mellinghoff, Philip Hopkins, Julian Hull, Helena Barcraft-Barnes, Lee Poole, Fiona Bottrill, Jessica Thrush, Anissa Benchiheub, Stuart Elliot, Fiona Pollock, Lauren Cooper, Grant Price, Teresa Martin, Leona Bannon, Sian Birch, Reni Jacob, Terry Martin, Gavin D. Perkins, Geraldine Ward, Donal Ryan, Esther Price, Petra Polgarova, Agnieszka Walecka, Katie Lei, Chris Nutt, Christopher Bassford, Laura Ortiz-Ruiz de Gordoa, Irfan Chaudry, Stephen E Wright
Publikováno v:
Irish Critical Care Trials Group 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial ', The Lancet Respiratory Medicine, vol. 6, no. 9, pp. 691-698 . https://doi.org/10.1016/S2213-2600(18)30177-2
Calfee, C, Delucchi, K, Sinha, P, Matthay, M, Hackett, J, Shankar-Hari, M, McDowell, C, G. Laffey, J, O’Kane, C & McAuley, D F 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin : Secondary Analysis of a Randomized Controlled Trial ', The lancet. Respiratory medicine . https://doi.org/10.1016/S2213-2600(18)30177-2
Calfee, C, Delucchi, K, Sinha, P, Matthay, M, Hackett, J, Shankar-Hari, M, McDowell, C, G. Laffey, J, O’Kane, C & McAuley, D F 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin : Secondary Analysis of a Randomized Controlled Trial ', The lancet. Respiratory medicine . https://doi.org/10.1016/S2213-2600(18)30177-2
Background: Precision medicine approaches targeting patients based on disease subtype have transformed approaches to cancer, asthma, and other heterogeneous syndromes. Two distinct subphenotypes of ARDS have been identified in three US-based clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383abcee6e51fb6ddb26ecb8bba26152
https://pure.qub.ac.uk/en/publications/acute-respiratory-distress-syndrome-subphenotypes-and-differential-response-to-simvastatin-secondary-analysis-of-a-randomised-controlled-trial(a0bb28cb-71b1-4ff0-b64d-387bd1418815).html
https://pure.qub.ac.uk/en/publications/acute-respiratory-distress-syndrome-subphenotypes-and-differential-response-to-simvastatin-secondary-analysis-of-a-randomised-controlled-trial(a0bb28cb-71b1-4ff0-b64d-387bd1418815).html
Lack of concordance between ECDC and CDC systems for surveillance of ventilator associated pneumonia
Autor:
Ian F. Laurenson, Thomas H. Craven, Gosha Wojcik, Esther Grant, J. McCoubrey, Timothy S. Walsh, Odette Brooks, Kallirroi Kefala, Jacqui Reilly
Publikováno v:
Craven, T, Wojcik, G, McCoubrey, J, Brooks, O, Grant, E, Reilly, J, Laurenson, I F, Kefala, K & Walsh, T 2018, ' Lack of concordance between ECDC and CDC systems for surveillance of ventilator associated pneumonia ', Intensive Care Medicine, vol. 44, no. 2, pp. 265 . https://doi.org/10.1007/s00134-017-4993-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de0f86b2514b0bc466cd547be722bd9
https://hdl.handle.net/20.500.11820/6b4edd15-22bb-4073-8545-49e28c8a746e
https://hdl.handle.net/20.500.11820/6b4edd15-22bb-4073-8545-49e28c8a746e
Autor:
Donald J. Davidson, Peter J. D. Andrews, Kallirroi Kefala, Timothy S. Walsh, Niall Anderson, David G. Swann, John R. W. Govan, Olga L. Moncayo-Nieto, A. John Simpson, Ian F. Laurenson, Jean-Michel Sallenave, Lesley Farrell, Kevin Dhaliwal, Andrew Conway Morris, Hamish Reid, Christopher Haslett, Thomas S. Wilkinson, Simon J. Mackenzie
Publikováno v:
Thorax
Conway-Morris, A, Kefala, K, Wilkinson, T S, Moncayo-Nieto, O L, Dhaliwal, K, Farrell, L, Walsh, T S, Mackenzie, S J, Swann, D G, Andrews, P J D, Anderson, N, Govan, J R W, Laurenson, I F, Reid, H, Davidson, D J, Haslett, C, Sallenave, J-M & Simpson, A J 2010, ' Diagnostic importance of pulmonary interleukin-1 beta and interleukin-8 in ventilator-associated pneumonia ', Thorax, vol. 65, no. 3, pp. 201-207 . https://doi.org/10.1136/thx.2009.122291
Conway-Morris, A, Kefala, K, Wilkinson, T S, Moncayo-Nieto, O L, Dhaliwal, K, Farrell, L, Walsh, T S, Mackenzie, S J, Swann, D G, Andrews, P J D, Anderson, N, Govan, J R W, Laurenson, I F, Reid, H, Davidson, D J, Haslett, C, Sallenave, J-M & Simpson, A J 2010, ' Diagnostic importance of pulmonary interleukin-1 beta and interleukin-8 in ventilator-associated pneumonia ', Thorax, vol. 65, no. 3, pp. 201-207 . https://doi.org/10.1136/thx.2009.122291
Background: Ventilator-associated pneumonia (VAP) is the most commonly fatal nosocomial infection. Clinical diagnosis of VAP remains notoriously inaccurate. The hypothesis was tested that significantly augmented inflammatory markers distinguish VAP f
Autor:
Niall Anderson, Ian Dimmick, Suveer Singh, Simon Baudouin, Stephen E Wright, Emma Browne, Daniel F. McAuley, Thomas P Hellyer, Nicole M Robin, John Widdrington, I. F. Laurenson, Andrew Conway Morris, Craig Spencer, Shondipon Laha, Timothy S. Walsh, Frans Nauwelaers, A. John Simpson, Jonathan Scott, Savita Gossain, Sarah Wiscombe, Gavin D. Perkins, Melinda Jeffels, Cecilia O'Kane, Kate Gould, Paul Dark, James G. Macfarlane, Alistair I Roy, Ronan McMullan, Marie-Hélène Ruchaud-Sparagano, Kallirroi Kefala
Publikováno v:
Hellyer, T P, Conway Morris, A, McAuley, D F, Walsh, T S, Anderson, N H, Singh, S, Dark, P, Roy, A I, Baudouin, S V, Wright, S E, Perkins, G D, Kefala, K, Jeffels, M, McMullan, R, O'Kane, C M, Spencer, C, Laha, S, Robin, N, Gossain, S, Gould, K, Ruchaud-Sparagano, M-H, Scott, J, Browne, E M, MacFarlane, J G, Wiscombe, S, Widdrington, J D, Dimmick, I, Laurenson, I F, Nauwelaers, F & Simpson, A J 2015, ' Diagnostic accuracy of pulmonary host inflammatory mediators in the exclusion of ventilator-acquired pneumonia ', Thorax, vol. 70, no. 1, pp. 41-47 . https://doi.org/10.1136/thoraxjnl-2014-205766
Background: Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion of infection may improve antibiotic stewardship in ventilator-acquired pneumonia (VAP). However, successful validation of the use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a110c92adc8abf9c19a9489bae9d28b
https://www.repository.cam.ac.uk/handle/1810/307336
https://www.repository.cam.ac.uk/handle/1810/307336