Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kalli Kappel"'
Autor:
Xin Liu, Tao Sun, Anna Shcherbina, Qin Li, Inga Jarmoskaite, Kalli Kappel, Gokul Ramaswami, Rhiju Das, Anshul Kundaje, Jin Billy Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.
Externí odkaz:
https://doaj.org/article/f291ffe598744dbb9b94da4931988805
Autor:
Kaiming Zhang, Shanshan Li, Kalli Kappel, Grigore Pintilie, Zhaoming Su, Tung-Chung Mou, Michael F. Schmid, Rhiju Das, Wah Chiu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
The conformational heterogeneity of RNA molecules makes their structure determination by X-ray crystallography and NMR challenging. Here the authors show that RNA structures can be solved by cryo-EM and present the structures of a 40 kDa SAM-IV ribos
Externí odkaz:
https://doaj.org/article/5de6b22e3c6a4ad29f1e5dabe8c50f5e
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background The understanding of the importance of RNA has dramatically changed over recent years. As in the case of proteins, the function of an RNA molecule is encoded in its tertiary structure, which in turn is determined by the molecule
Externí odkaz:
https://doaj.org/article/8bff1f97adab4e51ab2b602ab0a344ad
Typical drug discovery and development processes are costly, time consuming and often biased by expert opinion. Aptamers are short, single-stranded oligonucleotides (RNA/DNA) that bind to target proteins and other types of biomolecules. Compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160c58c7cc3fbfaa0b83d0827d77b436
https://doi.org/10.1101/2022.11.30.518473
https://doi.org/10.1101/2022.11.30.518473
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626863
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec5111fa1cb7993f9385e5aa1b87a033
https://doi.org/10.1007/978-1-0716-2687-0_13
https://doi.org/10.1007/978-1-0716-2687-0_13
Autor:
Haiyun, Ma, Phillip, Pham, Bingnan, Luo, Ramya, Rangan, Kalli, Kappel, Zhaoming, Su, Rhiju, Das
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2568
RNA three-dimensional structures provide rich and vital information for understanding their functions. Recent advances in cryogenic electron microscopy (cryo-EM) allow structure determination of RNAs and ribonucleoprotein (RNP) complexes. However, li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a54ce35f45f90fad257f6e5c8dc51813
https://pubmed.ncbi.nlm.nih.gov/36227570
https://pubmed.ncbi.nlm.nih.gov/36227570
Autor:
Shanshan, Li, Michael Z, Palo, Grigore, Pintilie, Xiaojing, Zhang, Zhaoming, Su, Kalli, Kappel, Wah, Chiu, Kaiming, Zhang, Rhiju, Das
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(37)
The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63942d8fd7f3d2a81d0f8bce835fbbf0
https://pubmed.ncbi.nlm.nih.gov/36067294
https://pubmed.ncbi.nlm.nih.gov/36067294
Autor:
Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E. Wilkinson, Soumya Kannan, F. Esra Demircioglu, Rui Yan, Momoko Shiozaki, Zhiheng Yu, Kira S. Makarova, Eugene V. Koonin, Rhiannon K. Macrae, Feng Zhang
Publikováno v:
Nature. 610(7932)
RNA-guided systems, such as CRISPR–Cas, combine programmable substrate recognition with enzymatic function, a combination that has been used advantageously to develop powerful molecular technologies1,2. Structural studies of these systems have illu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfae629cc6e40fae3d1d2f1a1a537528
https://pubmed.ncbi.nlm.nih.gov/36224386
https://pubmed.ncbi.nlm.nih.gov/36224386
Autor:
Wipapat Kladwang, Ramya Rangan, Ivan N Zheludev, Wah Chiu, Andrew M. Watkins, Zhaoming Su, Ved V Topkar, Kaiming Zhang, Rhiju Das, Shanshan Li, Joseph D. Yesselman, Kalli Kappel, Grigore D. Pintilie
Publikováno v:
Nature methods
The discovery and design of biologically important RNA molecules is outpacing three-dimensional structural characterization. Here, we demonstrate that cryo-electron microscopy can routinely resolve maps of RNA-only systems and that these maps enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfd7bf7535c0f5f3cd109ce914441ab
https://doi.org/10.1038/s41592-020-0878-9
https://doi.org/10.1038/s41592-020-0878-9
Autor:
Michael F. Schmid, Wah Chiu, Tung-Chung Mou, Rhiju Das, Shanshan Li, Zhaoming Su, Kaiming Zhang, Kalli Kappel, Grigore D. Pintilie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
Nature Communications
Nature Communications
Specimens below 50 kDa have generally been considered too small to be analyzed by single-particle cryo-electron microscopy (cryo-EM). The high flexibility of pure RNAs makes it difficult to obtain high-resolution structures by cryo-EM. In bacteria, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf93913c3bbfe652b1bda606972104f
http://link.springer.com/article/10.1038/s41467-019-13494-7
http://link.springer.com/article/10.1038/s41467-019-13494-7