Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Kalle Sigfridsson"'
Autor:
Krishna C. Aluri, Kalle Sigfridsson, Aixiang Xue, Niresh Hariparsad, Dermot McGinnity, Diane Ramsden
Publikováno v:
International Journal of Pharmaceutics. 636:122787
Publikováno v:
European Journal of Pharmaceutical Sciences. 128:128-136
AZ3411 was selected as a lead compound for the treatment of Inflammatory Bowel Disease (IBD). The present research aimed to perform an early pharmaceutical assessment of this NK antagonist candidate focusing on the challenging solid-state part of the
Autor:
Sofia Martinsson, Christopher J.H. Porter, Erik Michaëlsson, Kalle Sigfridsson, Anna Lindgren, Lennart Lindfors, Enyuan Cao, Luojuan Hu, Natalie L. Trevaskis, Urban Skantze
Publikováno v:
Journal of Controlled Release. 296:29-39
Lymphocytes play a central role in the pathology of a range of chronic conditions such as autoimmune disease, transplant rejection, leukemia, lymphoma HIV/AIDs and cardiometabolic diseases such as atherosclerosis. Current treatments for lymphocyte-as
Autor:
Aixiang Xue, Torbjörn Arvidsson, David J. Wagner, Kalle Sigfridsson, Guangnong Zhang, Marie Strimfors, Petar Pop-Damkov
Publikováno v:
International journal of pharmaceutics. 581
The aim of the present study was to evaluate and interpret the pharmacokinetic profiles after subcutaneous (s.c.) administration of crystalline AZ’72 nano- and microsuspensions to rodents. Both formulations were injected at 1.5 and 150 mg/kg to rat
Publikováno v:
International Journal of Pharmaceutics. 606:120883
In the present study we describe a way of working to overcome oral administration challenges in an early preclinical project. As candidate drugs were obtained, the preclinical delivery route was replaced by the intended route of the product and resou
Autor:
Kalle Sigfridsson, Karin E. Carlsson
Publikováno v:
European Journal of Pharmaceutical Sciences. 109:650-656
A candidate drug within the cardiovascular area was identified during early research and evaluated for further development. The aim was to understand and explain the degradation mechanisms for the present compound. The stability of the active pharmac
Publikováno v:
European Journal of Pharmaceutical Sciences. 104:262-272
A compound, which is a selective peroxisome proliferator activated receptor (PPAR) agonist, was investigated. The aim of the presented studies was to evaluate the potential of the further development of the compound. Fundamental physicochemical prope
Autor:
Kjetil Elvevold, Bård Smedsrød, Erik Michaëlsson, Lena Svensson, Lars Löfgren, Lennart Lindfors, Pär Nordell, Kalle Sigfridsson, Britt Fuglesteg, Urban Skantze, Pia Skantze
Publikováno v:
International Journal of Pharmaceutics. 524:248-256
A stabilized high drug load intravenous formulation could allow compounds with less optimal pharmacokinetic profiles to be developed. Polyethylene glycol (PEG)-ylation is a frequently used strategy for particle delivery systems to avoid the liver, th
Autor:
Svante Johansson, Bård Smedsrød, Urban Skantze, Lennart Lindfors, Pia Skantze, Kjetil Elvevold, Britt Fuglesteg, Iain Grant, Kalle Sigfridsson
Publikováno v:
International Journal of Pharmaceutics. 518:29-40
In the present work, milled nanocrystals of a poorly soluble compound using different stabilizers were prepared and characterized. The aim of the study was to evaluate a fundamental set of properties of the formulations prior to i.v. injection of the
Publikováno v:
International journal of pharmaceutics. 566
The objective of the study was to evaluate the pharmacokinetic profile after different subcutaneous (s.c.) administrations of nano- and microparticle suspensions of griseofulvin to mice. The solubility of the compound was determined as approximately