Insights into bear evolution from a Pleistocene polar bear genome

Autor: Tianying Lan, Kalle Leppälä, Crystal Tomlin, Sandra L. Talbot, George K. Sage, Sean D. Farley, Richard T. Shideler, Lutz Bachmann, Øystein Wiig, Victor A. Albert, Jarkko Salojärvi, Thomas Mailund, Daniela I. Drautz-Moses, Stephan C. Schuster, Luis Herrera-Estrella, Charlotte Lindqvist

Publikováno v: Lan, T, Leppälä, K, Tomlin, C, Talbot, S L, Sage, G K, Farley, S D, Shideler, R T, Bachmann, L, Wiig, Ø, Albert, V A, Salojärvi, J, Mailund, T, Drautz-Moses, D I, Schuster, S C, Herrera-Estrella, L & Lindqvist, C 2022, ' Insights into bear evolution from a Pleistocene polar bear genome ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 24 . https://doi.org/10.1073/pnas.2200016119

The polar bear (Ursus maritimus) has become a symbol of the threat to biodiversity from climate change. Understanding polar bear evolutionary history may provide insights into apex carnivore responses and prospects during periods of extreme environme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3960f62bacbae4c7a12b72d6127a1b0
http://hdl.handle.net/10138/348200

Genome-wide association study implicates CHRNA2 in cannabis use disorder

Autor: Kalle Leppälä, Ditte Demontis, Ole Mors, Thorarinn Tyrfingsson, Laura M. Huckins, Anders D. Børglum, Kari Stefansson, Mark J. Daly, David M. Hougaard, Carsten Hjorthøj, Daniel F. Gudbjartsson, Gunnar W Reginsson, Thomas Werge, Jane H. Christensen, Per Qvist, Eli A. Stahl, Hreinn Stefansson, Allan Timmermann, Valgerdur Runarsdottir, Thorgeir E. Thorgeirsson, Jonatan Pallesen, Esben Agerbo, Jonas Bybjerg-Grauholm, Merete Nordentoft, Jakob Grove, Preben Bo Mortensen, Marie Bækvad-Hansen, Mette Nyegaard, Veera M. Rajagopal, Thomas Damm Als

Publikováno v: Nature Neuroscience
Demontis, D, Rajagopal, V M, Thorgeirsson, T E, Als, T D, Grove, J, Leppälä, K, Gudbjartsson, D F, Pallesen, J, Hjorthøj, C, Reginsson, G W, Tyrfingsson, T, Runarsdottir, V, Qvist, P, Christensen, J H, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Huckins, L M, Stahl, E A, Timmermann, A, Agerbo, E, Hougaard, D M, Werge, T, Mors, O, Mortensen, P B, Nordentoft, M, Daly, M J, Stefansson, H, Stefansson, K, Nyegaard, M & Børglum, A D 2019, ' Genome-wide association study implicates CHRNA2 in cannabis use disorder ' Nature Neuroscience . https://doi.org/10.1038/s41593-019-0416-1
Demontis, D, Rajagopal, V M, Thorgeirsson, T E, Als, T D, Grove, J, Leppälä, K, Gudbjartsson, D F, Pallesen, J, Hjorthøj, C, Reginsson, G W, Tyrfingsson, T, Runarsdottir, V, Qvist, P, Christensen, J H, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Huckins, L M, Stahl, E A, Timmermann, A, Agerbo, E, Hougaard, D M, Werge, T, Mors, O, Mortensen, P B, Nordentoft, M, Daly, M J, Stefansson, H, Stefansson, K, Nyegaard, M & Børglum, A D 2019, ' Genome-wide association study implicates CHRNA2 in cannabis use disorder ', Nature Neuroscience, vol. 22, no. 7, pp. 1066-1074 . https://doi.org/10.1038/s41593-019-0416-1
Nat Neurosci
Demontis, D, Rajagopal, V M, Thorgeirsson, T E, Als, T D, Grove, J, Leppälä, K, Gudbjartsson, D F, Pallesen, J, Hjorthøj, C, Reginsson, G W, Tyrfingsson, T, Runarsdottir, V, Qvist, P, Christensen, J H, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Huckins, L M, Stahl, E A, Timmermann, A, Agerbo, E, Hougaard, D M, Werge, T, Mors, O, Mortensen, P B, Nordentoft, M, Daly, M J, Stefansson, H, Stefansson, K, Nyegaard, M & Børglum, A D 2019, ' Genome-wide association study implicates CHRNA2 in cannabis use disorder ', Nature Neuroscience, vol. 22, pp. 1066-1074 . https://doi.org/10.1038/s41593-019-0416-1

Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50db1468731ffda6e4321fc6e4f613a

Irrationality measures for almost periodic continued fractions

Autor: Marko E. Leinonen, Kalle Leppälä, Jaroslav Hančl, Silvia Dodulíková, Ondřej Kolouch

Publikováno v: Georgian Mathematical Journal. 23:55-67

We give general results which provide asymptotic irrationality measures and estimations for the denominators of the convergents for certain almost periodic simple continued fraction expansions. As an application we obtain new irrationality measures,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::287192efc55499a3e6379a043cca743d
https://doi.org/10.1515/gmj-2015-0056

The comparative genomics and complex population history of

Autor: Jeffrey, Rogers, Muthuswamy, Raveendran, R Alan, Harris, Thomas, Mailund, Kalle, Leppälä, Georgios, Athanasiadis, Mikkel Heide, Schierup, Jade, Cheng, Kasper, Munch, Jerilyn A, Walker, Miriam K, Konkel, Vallmer, Jordan, Cody J, Steely, Thomas O, Beckstrom, Christina, Bergey, Andrew, Burrell, Dominik, Schrempf, Angela, Noll, Maximillian, Kothe, Gisela H, Kopp, Yue, Liu, Shwetha, Murali, Konstantinos, Billis, Fergal J, Martin, Matthieu, Muffato, Laura, Cox, James, Else, Todd, Disotell, Donna M, Muzny, Jane, Phillips-Conroy, Bronwen, Aken, Evan E, Eichler, Tomas, Marques-Bonet, Carolin, Kosiol, Mark A, Batzer, Matthew W, Hahn, Jenny, Tung, Dietmar, Zinner, Christian, Roos, Clifford J, Jolly, Richard A, Gibbs, Kim C, Worley

Publikováno v: Science Advances

We analyzed genome sequences from 6 baboon species and found evidence of ancient and recent hybridization among divergent species.
Recent studies suggest that closely related species can accumulate substantial genetic and phenotypic differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5a6b9a0473cc399adf79b625b3fdb5e
https://pubmed.ncbi.nlm.nih.gov/30854422

Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

Autor: Li Zhang, Morigenbatu Morigenbatu, Stephen R. Bond, Xin Luo, Yingchun Liu, Tao Li, Ying Gao, Baozhu Guan, Chen Ye, Junwei Cao, Yujie Chen, Xiaolian Ning, Mingyang Jiang, Yiyi Liu, Dong Zhang, Qizhu Wu, Dandan Zhang, Yanping Xing, Wangsheng Li, Xueqiong Li, Xun Xu, Zhili Pei, Dingzhu Wang, Yanru Zhang, Xiaosen Guo, Lin Fang, Xin Liu, Fanhua Meng, Suyalatu Suyalatu, Burenbatu Burenbatu, Chunxia Liu, Tianming Lan, Zongze Wu, Christopher R. Gignoux, Ye Yin, Narisu Narisu, Liqing Yang, Huiguang Wu, Huanmin Zhou, Jirimutu Jirimutu, Bo Wang, Ningxin Dang, Kaifeng Wu, Wenhao Xu, Huanming Yang, Hashenqimuge Hashenqimuge, Shenyuan Wang, Yong Zhang, Lu Li, Haihua Bai, Kalle Leppälä, Jun Wang, Lawrence C. Brody, Karsten Kristiansen, Xukui Yang, Haorong Lu, Bingyi Ding, Huixin Xu

Publikováno v: Bai, H, Guo, X, Narisu, N, Lan, T, Wu, Q, Xing, Y, Zhang, Y, Bond, S R, Pei, Z, Zhang, Y, Zhang, D, Jirimutu, J, Zhang, D, Yang, X, Morigenbatu, M, Zhang, L, Ding, B, Guan, B, Cao, J, Lu, H, Liu, Y, Li, W, Dang, N, Jiang, M, Wang, S, Xu, H, Wang, D, Liu, C, Luo, X, Gao, Y, Li, X, Wu, Z, Yang, L, Meng, F, Ning, X, Hashenqimuge, H, Wu, K, Wang, B, Suyalatu, S, Liu, Y, Ye, C, Wu, H, Leppälä, K, Li, L, Fang, L, Chen, Y, Xu, W, Li, T, Liu, X, Xu, X, Gignoux, C R, Yang, H, Brody, L C, Wang, J, Kristiansen, K, Burenbatu, B, Zhou, H & Yin, Y 2018, ' Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia ', Nature Genetics, vol. 50, pp. 1696–1704 . https://doi.org/10.1038/s41588-018-0250-5

The genetic variation in Northern Asian populations is currently undersampled. To address this, we generated a new genetic variation reference panel by whole-genome sequencing of 175 ethnic Mongolians, representing six tribes. The cataloged variation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad35f0187a2180915c5a4f17a3e7c48
https://pure.au.dk/portal/da/publications/wholegenome-sequencing-of-175-mongolians-uncovers-populationspecific-genetic-architecture-and-gene-flow-throughout-north-and-east-asia(174df42b-304c-4c4a-a3c2-846d0b48fa3e).html