Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Kalkunte S. Srivenugopal"'
Publikováno v:
Cells, Vol 13, Iss 15, p 1272 (2024)
Human NAD(P)H-quinone oxidoreductase1 (HNQO1) is a two-electron reductase antioxidant enzyme whose expression is driven by the NRF2 transcription factor highly active in the prooxidant milieu found in human malignancies. The resulting abundance of NQ
Externí odkaz:
https://doaj.org/article/81f67f9972c74e4f8ff56e350ec1b973
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 305-323 (2018)
Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma an
Externí odkaz:
https://doaj.org/article/188c8ca4ac824ea7b6c4851b2b0de682
Publikováno v:
Genes, Vol 12, Iss 6, p 888 (2021)
Background: The therapeutically important DNA repair gene O6-methylguanine DNA methyltransferase (MGMT) is silenced by promoter methylation in human brain cancers. The co-players/regulators associated with this process and the subsequent progression
Externí odkaz:
https://doaj.org/article/76be742c2e3440eead403cb6f474e178
Autor:
Mohammed A. Ibrahim Al-Obaide, Viswanath Arutla, Manny D. Bacolod, Wei Wang, Ruiwen Zhang, Kalkunte S. Srivenugopal
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2492 (2021)
Background: The molecular regulation of increased MGMT expression in human brain tumors, the associated regulatory elements, and linkages of these to its epigenetic silencing are not understood. Because the heightened expression or non-expression of
Externí odkaz:
https://doaj.org/article/f17df3d5e13b48f3a14d8a7dc1418671
Autor:
Surendra R. Punganuru, Viswanath Arutla, Wei Zhao, Mehrdad Rajaei, Hemantkumar Deokar, Ruiwen Zhang, John K. Buolamwini, Kalkunte S. Srivenugopal, Wei Wang
Publikováno v:
Cells, Vol 9, Iss 7, p 1592 (2020)
There is a desperate need for novel and efficacious chemotherapeutic strategies for human brain cancers. There are abundant molecular alterations along the p53 and MDM2 pathways in human glioma, which play critical roles in drug resistance. The prese
Externí odkaz:
https://doaj.org/article/0aba6ac868e54a4a99c45cc966adebbf
Publikováno v:
Cancers, Vol 10, Iss 12, p 470 (2018)
Human NAD(P)H quinone oxidoreductase-1 (hNQO1) is an important cancer-related biomarker, which shows significant overexpression in malignant cells. Developing an effective method for detecting NQO1 activity with high sensitivity and selectivity in tu
Externí odkaz:
https://doaj.org/article/8bfa096ea6754556a9e3e6ba33b9cb1d
Autor:
Hanumantha Rao Madala, Surendra R. Punganuru, Viswanath Arutla, Subhasis Misra, T. J. Thomas, Kalkunte S. Srivenugopal
Publikováno v:
Cancers, Vol 10, Iss 2, p 49 (2018)
Isocitrate dehydrogenases 1 and 2 (IDH1,2), the key Krebs cycle enzymes that generate NADPH reducing equivalents, undergo heterozygous mutations in >70% of low- to mid-grade gliomas and ~20% of acute myeloid leukemias (AMLs) and gain an unusual new a
Externí odkaz:
https://doaj.org/article/2e3cc98806044d53a8835a74693c53dc
Publikováno v:
Cancer Research. 83:457-457
NAD(P)H-quinone oxidoreductase 1 (NQO1) is a rational target for designing tumor-selective anticancer therapies because the 2-electron reductase is expressed at very low levels in normal tissues but present abundantly (5 to 200-fold) in human cancers
Publikováno v:
Cancer Research. 82:1826-1826
Background: Disulfiram (DSF) in combination with copper pills has emerged as a safe and exciting anticancer strategy and is undergoing clinical trials in multiple human cancers. However, DSF breaks down in the gut or blood immediately and chances of
Autor:
Racheal G, Akwii, Md S, Sajib, Fatema T, Zahra, Hanumantha R, Madala, Kalkunte S, Srivenugopal, Constantinos M, Mikelis
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2193
Lymphangiogenesis, the formation of lymphatic vessels from preexisting ones, is an important process in wound-healing physiology. Deregulation of lymphangiogenesis and lymphatic vascular remodeling have been implicated in a range of inflammatory cond