Zobrazeno 1 - 10
of 418
pro vyhledávání: '"Kalkunte S"'
Publikováno v:
Cells, Vol 13, Iss 15, p 1272 (2024)
Human NAD(P)H-quinone oxidoreductase1 (HNQO1) is a two-electron reductase antioxidant enzyme whose expression is driven by the NRF2 transcription factor highly active in the prooxidant milieu found in human malignancies. The resulting abundance of NQ
Externí odkaz:
https://doaj.org/article/81f67f9972c74e4f8ff56e350ec1b973
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 305-323 (2018)
Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma an
Externí odkaz:
https://doaj.org/article/188c8ca4ac824ea7b6c4851b2b0de682
Autor:
Surendra R. Punganuru, Viswanath Arutla, Wei Zhao, Mehrdad Rajaei, Hemantkumar Deokar, Ruiwen Zhang, John K. Buolamwini, Kalkunte S. Srivenugopal, Wei Wang
Publikováno v:
Cells, Vol 9, Iss 7, p 1592 (2020)
There is a desperate need for novel and efficacious chemotherapeutic strategies for human brain cancers. There are abundant molecular alterations along the p53 and MDM2 pathways in human glioma, which play critical roles in drug resistance. The prese
Externí odkaz:
https://doaj.org/article/0aba6ac868e54a4a99c45cc966adebbf
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
In Neoplasia April 2018 20(4):305-323
Autor:
Punganuru, Surendra R., Madala, Hanumantha Rao, Venugopal, Sanjay N., Samala, Ramakrishna, Mikelis, Constantinos, Srivenugopal, Kalkunte S.
Publikováno v:
In European Journal of Medicinal Chemistry 1 January 2016 107:233-244
Publikováno v:
Cancer Research. 83:457-457
NAD(P)H-quinone oxidoreductase 1 (NQO1) is a rational target for designing tumor-selective anticancer therapies because the 2-electron reductase is expressed at very low levels in normal tissues but present abundantly (5 to 200-fold) in human cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4902c3711241afba2b5fad02b4b8b9
https://doi.org/10.1158/1538-7445.am2023-457
https://doi.org/10.1158/1538-7445.am2023-457
Publikováno v:
In Placenta 2011 32 Supplement 2:182-185
Publikováno v:
In Free Radical Biology and Medicine 2010 49(5):908-917
Publikováno v:
Cancer Research. 82:1826-1826
Background: Disulfiram (DSF) in combination with copper pills has emerged as a safe and exciting anticancer strategy and is undergoing clinical trials in multiple human cancers. However, DSF breaks down in the gut or blood immediately and chances of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50dbfb18f09a1824718a3d52ef8b3bc9
https://doi.org/10.1158/1538-7445.am2022-1826
https://doi.org/10.1158/1538-7445.am2022-1826