Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.

Autor: Lyu J; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Liu Y; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Gong L; Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, and Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas., Chen M; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas., Madanat YF; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Zhang Y; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Cai F; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas., Gu Z; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Cao H; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Kaphle P; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Kim YJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Kalkan FN; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Stephens H; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Dickerson KE; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Ni M; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas., Chen W; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas., Patel P; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Mims AS; Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Borate U; Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health and Science University, Portland, Oregon., Burd A; The Leukemia & Lymphoma Society, Rye Brook, New York., Cai SF; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Yin CC; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., You MJ; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Chung SS; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., Collins RH; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas., DeBerardinis RJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas., Liu X; Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology, and Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas., Xu J; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Publikováno v: Cancer discovery [Cancer Discov] 2023 Jan 09; Vol. 13 (1), pp. 170-193.