Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kalinka Koteva"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and persistence. Many microbes produce metallophores to sequester meta
Externí odkaz:
https://doaj.org/article/4aa65b692be64fb8949c5685458bac17
Autor:
Kalinka Koteva, David Sychantha, Caitlyn M. Rotondo, Christian Hobson, James F. Britten, Gerard D. Wright
Publikováno v:
ACS Omega, Vol 7, Iss 5, Pp 4170-4184 (2022)
Externí odkaz:
https://doaj.org/article/a352359fcc404397a4fd4bbfb0735b05
Autor:
Emily Bordeleau, Peter J. Stogios, Elena Evdokimova, Kalinka Koteva, Alexei Savchenko, Gerard D. Wright
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Apramycin is an aminoglycoside antibiotic that has been traditionally used in veterinary medicine. Recently, it has become an attractive candidate to repurpose in the fight against multidrug-resistant pathogens prioritized by the World Health Organiz
Externí odkaz:
https://doaj.org/article/41564d3daac1455389836743598c7dac
Autor:
Andrew C. Pawlowski, Peter J. Stogios, Kalinka Koteva, Tatiana Skarina, Elena Evdokimova, Alexei Savchenko, Gerard D. Wright
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
New antibiotics with reduced potential for resistance are urgently needed. Here, the authors use a multidisciplinary approach to characterize substrate discrimination in macrolide resistance kinases and present a strategy for the prediction of mutati
Externí odkaz:
https://doaj.org/article/8d1fd42155f34c23acbadc3b6245e7ca
Autor:
Andrew C. Pawlowski, Wenliang Wang, Kalinka Koteva, Hazel A. Barton, Andrew G. McArthur, Gerard D. Wright
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Antibiotic resistance is common in environmental bacteria, including those living in isolated caves. Here, Pawlowskiet al. study one of these bacterial strains, showing that it is resistant to most clinically used antibiotics through a remarkable var
Externí odkaz:
https://doaj.org/article/1c93c76c9fd94ed0a4d6faec6d60a6e2
Autor:
Peter J. Stogios, Georgina Cox, Peter Spanogiannopoulos, Monica C. Pillon, Nicholas Waglechner, Tatiana Skarina, Kalinka Koteva, Alba Guarné, Alexei Savchenko, Gerard D. Wright
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Antibiotic resistance is a major clinical problem that threatens to undermine our ability to control infectious diseases. Here the authors present detailed structural analysis of Rifampin phosphotransferase from Listeria monocytogenes, yielding insig
Externí odkaz:
https://doaj.org/article/64b0a2b6d6ba4b86bd0e1b03eb366200
Autor:
Kirandeep Bhullar, Nicholas Waglechner, Andrew Pawlowski, Kalinka Koteva, Eric D Banks, Michael D Johnston, Hazel A Barton, Gerard D Wright
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34953 (2012)
Antibiotic resistance is a global challenge that impacts all pharmaceutically used antibiotics. The origin of the genes associated with this resistance is of significant importance to our understanding of the evolution and dissemination of antibiotic
Externí odkaz:
https://doaj.org/article/4ffb073d505044cea51ba0be9129b67e
Autor:
Derek C. K. Chan, Inokentijs Josts, Kalinka Koteva, Gerard D. Wright, Henning Tidow, Lori L. Burrows
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 120(16), e2221253120 (2023). doi:10.1073/pnas.2221253120
Proceedings of the National Academy of Sciences of the United States of America 120(16), e2221253120 (2023). doi:10.1073/pnas.2221253120
The outer membrane of gram-negative bacteria prevents many antibiotics from reaching intracellular targets.
The outer membrane of gram-negative bacteria prevents many antibiotics from reaching intracellular targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b016aba5995b00f6965d0b948bf47e8
Autor:
Derek C. K. Chan, Inokentijs Josts, Kalinka Koteva, Gerard D. Wright, Henning Tidow, Lori L. Burrows
The outer membrane of Gram-negative bacteria prevents many antibiotics from reaching intracellular targets. However, some antimicrobials can take advantage of iron import transporters to cross this barrier. We showed previously that the thiopeptide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c382059b947a8c4692b19eb38efb9bf9
https://doi.org/10.1101/2022.11.18.517105
https://doi.org/10.1101/2022.11.18.517105
Autor:
Michael S. Van Nieuwenhze, David Sychantha, Gerard D. Wright, Yen-Pang Hsu, Nicholas Waglechner, Wenliang Wang, Yves V. Brun, Elizabeth J. Culp, Brian K. Coombes, Aline Fiebig-Comyn, Kalinka Koteva
Publikováno v:
Nature. 578:582-587
Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel mechanisms of action that are capable of treating drug-resistant infections1. Many antibiotics are sourced from specialized metabolites produced by bacteria, part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb06264507a24b1d5818a4e465ec676
https://doi.org/10.1038/s41586-020-1990-9
https://doi.org/10.1038/s41586-020-1990-9