Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kalin Mayberry"'
Autor:
Jonathan Yen, Gregory A. Newby, Kalin Mayberry, Akshay Sharma, Michelle Richter, Thiyagaraj Mayuranathan, Kevin T. Zhao, Cicera R. Lazzarotto, Christophe Lechauve, Theodosia A. Kalfa, Elizabeth Thaman, Luke W. Koblan, Shondra M. Pruett-Miller, Heather Sheppard-Tillman, David R. Liu, Mitchell J. Weiss, Shengdar Q. Tsai, John F. Tisdale, Kaitly J. Woodard, Yoonjeong Jang, Christopher J. Podracky, Kelcee A. Everette, Shannon M. Miller, Tina Wang, Shaina N. Porter, Anton P. McCaffrey, Jordana M. Henderson, Yichao Li, Yu Yao
Publikováno v:
Nature
Sickle cell disease (SCD) is caused by a mutation in the β-globin gene HBB1. We used a custom adenine base editor (ABE8e-NRCH)2,3 to convert the SCD allele (HBBS) into Makassar β-globin (HBBG), a non-pathogenic variant4,5. Ex vivo delivery of mRNA
Autor:
Thiyagaraj Mayuranathan, Gregory A. Newby, Ruopeng Feng, Yu Yao, Kalin Mayberry, Guolian Kang, Cicera Lazzarotto, Yichao Li, Rachel Levine, Erin Dempsey, Shaina N. Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Senthil Bhoopalan, Nikitha Nimmagadda, Akshay Sharma, John Tisdale, Shondra Miller, Yong Cheng, Shengdar Tsai, Mitchell J. Weiss, David R. Liu, Jonathan S Yen
Publikováno v:
Blood. 140:7784-7785
Autor:
Richa Sharma, Senthil Bhoopalan, Lei Han, Yu Yao, Kalin Mayberry, Baranda S Hansen, Shondra Miller, Claudia Khurana, Miriam Erlacher, Marcin W Wlodarski
Publikováno v:
Blood. 140:2955-2956
Autor:
Georgios E. Christakopoulos, Thiyagaraj Mayuranathan, Alfonso G. Fernandez, Kalin Mayberry, Yu Yao, Rahul Telange, Michael Dudley, Rachel Levine, Erin Dempsey, David R. Liu, Jonathan S Yen, Mitchell J. Weiss
Publikováno v:
Blood. 140:10660-10661
Autor:
Ruopeng Feng, Thiyagaraj Mayuranathan, Peng Huang, Phillip A. Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E. Palmer, Kalin Mayberry, Georgios E. Christakopoulos, Peng Xu, Chunliang Li, Yong Cheng, Gerd A. Blobel, M. Celeste Simon, Mitchell J. Weiss
Publikováno v:
Nature
Around birth, globin expression in human red blood cells (RBCs) shifts from γ-globin to β-globin, resulting in fetal hemoglobin (HbF, α2γ2) being gradually replaced by adult hemoglobin (HbA, α2β2) (1). This process has motivated innovative appr
Autor:
Yiping Fan, Junmin Peng, Yuxin Li, Wenjian Bi, Lance E. Palmer, Hong Wang, Arno F. Alpi, Li Cheng, Daniel C. Scott, Yu Yao, Moeko T. King, Brenda A. Schulman, Florian Bassermann, Beisi Xu, Ruopeng Feng, Chunliang Li, Yong-Dong Wang, Ria Spallek, Mitchell J. Weiss, Yong Cheng, James B Papizan, Kalin Mayberry, Shondra M. Pruett-Miller, Peng Xu
Publikováno v:
Blood
The histone mark H3K27me3 and its reader/writer polycomb repressive complex 2 (PRC2) mediate widespread transcriptional repression in stem and progenitor cells. Mechanisms that regulate this activity are critical for hematopoietic development but are
Autor:
Thiyagaraj Mayuranathan, Senthil Velan Bhoopalan, Robert Throm, Jonathan Yen, Mitchell J. Weiss, Yu Yao, Marcin W. Wlodarski, Sheng Zhou, Kalin Mayberry
Publikováno v:
Blood. 138:859-859
Diamond-Blackfan anemia (DBA) is a congenital hypoplastic anemia that typically manifests in infancy as macrocytic anemia with reticulocytopenia. About 80% of DBA cases are caused by heterozygous loss-of-function mutations or deletions in one of 23 r
Autor:
Jingjing Zhang, Ruopeng Feng, Peng Huang, Yong Cheng, M. Celeste Simon, Yu Yao, Kalin Mayberry, Lance E. Palmer, Yichao Li, Gerd A. Blobel, Shaela Wright, Phillip A. Doerfler, Peng Xu, Thiyagaraj Mayuranathan, Mitchell J. Weiss, Chunliang Li
Publikováno v:
Blood. 138:574-574
Defining the mechanisms that control the perinatal switch from γ-globin (HBG1 and HBG2) to β-globin (HBB) gene expression in human red blood cells (RBCs) has informed novel approaches to reactivate fetal hemoglobin (HbF, α2γ2) therapeutically for
Autor:
Jingjing Zhang, Shaina N. Porter, Jonathan Yen, Kalin Mayberry, Kaitly J. Woodard, Gregory A. Newby, Jonathan S Yen, Kelcee A. Everette, Mitchell J. Weiss, Anton P. McCaffrey, Thiyagaraj Mayuranathan, Jordana M. Henderson, John F. Tisdale, Shengdar Q. Tsai, Yu Yao, David R. Liu
Publikováno v:
Blood. 136:13-14
Sickle cell disease (SCD) is a chronic, life-altering multisystem disorder that affects millions of individuals worldwide. Strategies for genetic therapy of autologous SCD hematopoietic stem cells (HSCs) include lentiviral vector (LV) delivery of an
Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling
Autor:
John F. Tisdale, Jingjing Zhang, Shengdar Q. Tsai, Yu Yao, David R. Liu, Gregory A. Newby, Akshay Sharma, Kaitly J. Woodard, Thiyagaraj Mayuranathan, Mitchell J. Weiss, Shondra M. preutt-Miller, Jonathan Yen, Shaina N. Porter, Kalin Mayberry
Publikováno v:
Blood. 136:21-22
Rare variants in the γ-globin (HBG2 and HBG1) promoters cause sustained postnatal expression of fetal hemoglobin (HbF, α2γ2) in red blood cells (RBCs). This benign condition is termed hereditary persistence of fetal hemoglobin (HPFH). Individuals