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Akademický článek

Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy

Autor: Wilson, Kaley D., de Jong, Susan D., Tam, Ying K.

Publikováno v: In Advanced Drug Delivery Reviews 2009 61(3):233-242

Akademický článek

The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN.

Autor: Raney, Sameersingh G.¹ (AUTHOR), Wilson, Kaley D.^1,2 (AUTHOR) kaley@interchange.ubc.ca, Sekirov, Laura¹ (AUTHOR), Chikh, Ghania¹ (AUTHOR), de Jong, Susan D.² (AUTHOR), Cullis, Pieter R.² (AUTHOR), Tam, Ying K.¹ (AUTHOR)

Publikováno v: Journal of Drug Targeting. Aug2008, Vol. 16 Issue 7/8, p564-577. 14p. 8 Graphs.

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Abstract P4-13-04: Estrogen and Avoidance of Invasive Breast Cancer, Coronary Heart Disease and All-cause Mortality. Public Health Impact of Estrogen Guidelines for Women entering Menopause

Autor: Hubert Wong, Shayan Shakeraneh, Joseph Ragaz, Kaley D. Wilson, J Budlovsky

Publikováno v: Cancer Research. 72:P4-13

BACKGROUND. Estrogen [E] for women entering menopause is not perceived beneficial for either iBrCa or CHD. However, data from RCTs suggest that use of Estrogen reduces: a. rates of invasive breast cancer [iBrCa], andb. atherogenesis, vessel pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9abe83bb7859a3406dfc2e9bba45416d
https://doi.org/10.1158/0008-5472.sabcs12-p4-13-04

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Abstract P6-09-09: Dual Estrogen Effects on Breast Cancer: Endogenous Estrogen Stimulates, Exogenous Estrogen Protects. Further Investigation of Estrogen Chemoprevention Is Warranted

Autor: Kaley D. Wilson, G Muraca, J. Froehlich, Joseph Ragaz, J Budlovsky

Publikováno v: Cancer Research. 70:P6-09

Introduction Until the randomized Women Healths Initiative [WHI] trials 1,2, most hormone replacement therapy (HRT) studies showed an association of HRT with higher BrCa risk. However, our recent reviews of the WHI trials suggested that Estrogen alon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf52651e2e55e39ca8e576036572b89e
https://doi.org/10.1158/0008-5472.sabcs10-p6-09-09

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Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles

Autor: Susan D. de Jong, Pieter R. Cullis, Sameersingh G. Raney, Laura Sekirov, Jan P. Dutz, Ghania Chikh, Mikameh Kazem, Ying K. Tam, Kaley D. Wilson

Publikováno v: International Immunology. 21:757-767

Although it is well documented that the immunological activity of cytosine-guanine (CpG) motifs is abrogated by 5' methylation of the cytosine residue, encapsulation within stabilized lipid nanoparticles endows these methylated cytosine-guanine- (mCp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996d6b6640c815b4beb30496c1ecd9fa
https://doi.org/10.1093/intimm/dxp044

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Lipid-based delivery of CpG oligodeoxynucleotides for cancer immunotherapy

Autor: Ying K. Tam, Kaley D. Wilson

Publikováno v: Expert review of clinical pharmacology. 2(2)

The anti-tumor activity of CpG-containing oligodeoxynucleotides (ODNs) has been well established in numerous animal models and confirmed in a number of early clinical trials. While the use of chemical modifications has effectively reduced the sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8a2ea1204151192a143d3a0a8bd7ae
https://pubmed.ncbi.nlm.nih.gov/24410650

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The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes

Autor: Pieter R. Cullis, Ying Tam, Mikameh Kazem, Susan D. de Jong, Wilf Jefferies, Genc Basha, Kaley D. Wilson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 184(11)

TLR9 recognizes CpG motifs present in pathogenic DNA and triggers potent immune responses. It is generally accepted that TLR9 distinguishes pathogenic DNA based, in part, on methylation status, where TLR9 binds unmethylated but not methylated CpG. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9d7c5161a3446a5fcc9e52f9959315
https://pubmed.ncbi.nlm.nih.gov/20427776

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The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine

Autor: Pieter R. Cullis, Ying K. Tam, Kaley D. Wilson, Michael J. Hope, Susan D. de Jong, Mikameh Kazem, Ryan Lall

Publikováno v: The journal of gene medicine. 11(1)

Background DNA vaccines offer unique potential for generating protective and therapeutic immunity against infectious and malignant diseases. Unfortunately, rapid degradation and poor cellular uptake has significantly limited the efficacy of ‘naked�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92917e5186185b625515df24d44cd79
https://pubmed.ncbi.nlm.nih.gov/19003796

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