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of 5
pro vyhledávání: '"Kaley A. Graves"'
Autor:
Angelika Doetzlhofer, Kaley A. Graves, Brandon C. Cox, Elena Chrysostomou, Luyi Zhou, Yuanzhao L. Darcy
Publikováno v:
J Neurosci
During cochlear development, the Notch ligand JAGGED 1 (JAG1) plays an important role in the specification of the prosensory region, which gives rise to sound-sensing hair cells and neighboring supporting cells (SCs). While JAG1's expression is maint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0c0af619deefeddcc9b9701957f931
https://doi.org/10.1523/jneurosci.1192-20.2020
https://doi.org/10.1523/jneurosci.1192-20.2020
Autor:
Brandon C. Cox, Angelika Doetzlhofer, Yuanzhao L. Darcy, Luyi Zhou, Kaley A. Graves, Elena Chrysostomou
During cochlear development, the Notch ligand JAGGED 1 (JAG1) plays an important role in the specification of the prosensory region, which gives rise to sound-sensing hair cells and neighboring supporting cells (SCs). While JAG1’s expression is mai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf5960859bdb90f0dffd5072c26662d
Publikováno v:
Development (Cambridge, England). 146(4)
Supporting cells (SCs) are known to spontaneously regenerate hair cells (HCs) in the neonatal mouse cochlea, yet little is known about the relative contribution of distinct SC subtypes which differ in morphology and function. We have previously shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8104cf9ed3187bcc0f91d712888cb3b
https://pubmed.ncbi.nlm.nih.gov/30770379
https://pubmed.ncbi.nlm.nih.gov/30770379
Age-related hearing loss is experienced by one-third of individuals aged 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4e2afca6ce8dd2ff62c30bdd741f87
https://europepmc.org/articles/PMC5743589/
https://europepmc.org/articles/PMC5743589/
Four CreER lines that are commonly used in the auditory field to label cochlear supporting cells (SCs) are expressed in multiple SC subtypes, with some lines also showing reporter expression in hair cells (HCs). We hypothesized that altering the tamo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3580bd6139b3305e45b980b1b544f9c1
https://europepmc.org/articles/PMC5352607/
https://europepmc.org/articles/PMC5352607/