Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kalev Takkis"'
Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life
Autor:
Rūta Veigure, Joseph F. Standing, Kalev Takkis, Joel Starkopf, Kristel Köbas, Tuuli Metsvaht, Mari-Liis Ilmoja, Maarja Hallik, Margit Sõnajalg, Hiie Soeorg, Karin Kipper, Maila Raidmäe, Karin Uibo, Tiiu Jalas
Publikováno v:
British Journal of Clinical Pharmacology
Aims To describe the pharmacokinetics (PK) and concentration‐related effects of https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=535 in critically ill neonates in the first days of life, using nonlinear mixed effects modelling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d7a2dbecd2e6ee3be7cb161304ba1c
https://doi.org/10.1111/bcp.14146
https://doi.org/10.1111/bcp.14146
Autor:
Mari-Liis Ilmoja, Maarja Hallik, Tõnis Tasa, Rūta Veigure, Karin Kipper, Karin Uibo, Tiiu Jalas, Joseph F. Standing, Kalev Takkis, Maila Raidmäe, Joel Starkopf, Tuuli Metsvaht
Publikováno v:
Pediatric Critical Care Medicine. 20:621-629
The postoperative course of patent ductus arteriosus ligation is often complicated by postligation cardiac syndrome, occurring in 10-45% of operated infants. Milrinone might prevent profound hemodynamic instability and improve the recovery of cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e149650b02c48ec93cc4d1b079472cd
https://doi.org/10.1097/pcc.0000000000001879
https://doi.org/10.1097/pcc.0000000000001879
Autor:
Joel Starkopf, Kalev Takkis, Tuuli Metsvaht, Rūta Veigure, Maarja Hallik, Karin Kipper, Mari-Liis Ilmoja
Publikováno v:
Clinical Mass Spectrometry. 12:23-29
The purpose of this work was to develop and validate an HPLC-MS/MS method suitable for quantifying two important cardiovascular drugs, milrinone and dobutamine, in neonatal and paediatric patients’ blood plasma samples. Sufficiently low LLOQ levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a2561c33d0859183d5ddfeb1441891
https://doi.org/10.1016/j.clinms.2019.03.003
https://doi.org/10.1016/j.clinms.2019.03.003
Autor:
Jana Lass, Heili Varendi, Lenne-Triin Kõrgvee, Rudolf Aro, Karin Kipper, Kalev Takkis, Koit Herodes
Publikováno v:
Analytical and Bioanalytical Chemistry
This paper describes an LC-MS/MS method to determine the concentration of spironolactone and its metabolites 7-alpha-methylthiospironolactone and canrenone in blood plasma samples. The resulting assay is simple (using protein precipitation for sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb09ca5d2841ddba8bfac32b9c781591
http://europepmc.org/articles/PMC5395588
http://europepmc.org/articles/PMC5395588
Autor:
Kalev, Takkis, Rūta, Veigure, Tuuli, Metsvaht, Maarja, Hallik, Mari-Liis, Ilmoja, Joel, Starkopf, Karin, Kipper
Publikováno v:
Clin Mass Spectrom
The purpose of this work was to develop and validate an HPLC-MS/MS method suitable for quantifying two important cardiovascular drugs, milrinone and dobutamine, in neonatal and paediatric patients’ blood plasma samples. Sufficiently low LLOQ levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c1b0589d81a6551d78f3b729464c332
https://pubmed.ncbi.nlm.nih.gov/34841076
https://pubmed.ncbi.nlm.nih.gov/34841076
Autor:
Charlotte I. S. Barker, Hanno Evard, Lewis Couchman, Rūta Veigure, Kalev Takkis, Ivo Leito, Joseph F. Standing, Karin Kipper, Koit Herodes, Max Hecht, Atholl Johnston
Publikováno v:
Bioanalysis. 10(15)
Traditionally, bioanalytical laboratories do not report actual concentrations for samples with results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method calibration range established during validation and no data are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b1f2bc7fb9184aa2b721e45faba86b
https://pubmed.ncbi.nlm.nih.gov/30033744
https://pubmed.ncbi.nlm.nih.gov/30033744
Publikováno v:
Molecular Informatics. 34:485-492
A virtual screening to find novel inhibitors for HIV protease was performed on the ZINC database.1 A critical part in virtual screening and associated techniques is preliminary database filtering and size reduction and for that purpose a novel featur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be005326885e51d11a14243212424fd
https://doi.org/10.1002/minf.201400170
https://doi.org/10.1002/minf.201400170
Autor:
Rynno Lohmus, Kalev Takkis, Karin Kipper, Max Hecht, Koit Herodes, Rudolf Aro, Hanno Evard, Ru Ta Veigure, Ivo Leito
Publikováno v:
Analytical chemistry. 89(21)
Sample preparation for the analysis of clinical samples with the mass spectrometer (MS) can be extensive and expensive. Simplifying and speeding up the process would be very beneficial. This paper reports sponge spray—a novel sampling and direct MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ea68e48a11f660bc8ecc4eee7fe10f
https://pubmed.ncbi.nlm.nih.gov/29028329
https://pubmed.ncbi.nlm.nih.gov/29028329
Publikováno v:
QSAR & Combinatorial Science. 28:829-833
A QSAR analysis was carried out on a dataset of 126 anthraquinone-based cytotoxic compounds. A PCA of the molecular descriptors was used to cluster the dataset into smaller subsets according to their structural features and QSAR models were derived f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea68df7e9a0c305581611460e4d08039
https://doi.org/10.1002/qsar.200860180
https://doi.org/10.1002/qsar.200860180
Autor:
Sulev Sild, Kalev Takkis
Publikováno v:
QSAR & Combinatorial Science. 28:52-58
A Quantitative Structure–Activity Relationship (QSAR) analysis was carried out on a dataset of 135 six- and seven-membered cyclic urea-based Human Immunodeficiency Virus Type 1 (HIV-1) protease inhibitors. Using a larger and more diverse dataset th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ac27c3a950a3315ac7a79b3b4849aa0
https://doi.org/10.1002/qsar.200860006
https://doi.org/10.1002/qsar.200860006