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pro vyhledávání: '"Kaleigh E. Schuler"'
Autor:
Rachel K. Lex, Weiqiang Zhou, Zhicheng Ji, Kristin N. Falkenstein, Kaleigh E. Schuler, Kathryn E. Windsor, Joseph D. Kim, Hongkai Ji, Steven A. Vokes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
GLI repression has been presumed to be the default transcriptional state and important for pre-patterning tissues. Challenging current models, the authors show that GLI3 repression is inert in the limb bud before the onset of Hedgehog signaling.
Externí odkaz:
https://doaj.org/article/f4ffb194bc634fada5ef10e4055ad247
Autor:
Kaleigh E. Schuler, Steven A. Vokes, Weiqiang Zhou, Rachel K. Lex, Kristin N. Falkenstein, Joseph Kim, Hongkai Ji, Kathryn E. Windsor, Zhicheng Ji
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
SummaryIn the absence of Hedgehog (HH) signaling, GLI proteins are post-translationally modified within cilia into transcriptional repressors that subsequently prevent sub-threshold activation of HH target genes. GLI repression is presumably importan
Autor:
Rachel K, Lex, Weiqiang, Zhou, Zhicheng, Ji, Kristin N, Falkenstein, Kaleigh E, Schuler, Kathryn E, Windsor, Joseph D, Kim, Hongkai, Ji, Steven A, Vokes
Publikováno v:
Nature communications. 13(1)
The Hedgehog (HH) pathway regulates a spectrum of developmental processes through the transcriptional mediation of GLI proteins. GLI repressors control tissue patterning by preventing sub-threshold activation of HH target genes, presumably even befor