Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kaleb M. Naegeli"'
Autor:
Kaleb M. Naegeli, Mehmet H. Kural, Yuling Li, Juan Wang, Emmanuelle A. Hugentobler, Laura E. Niklason
Publikováno v:
Circulation Research. 131:109-126
Cardiovascular defects, injuries, and degenerative diseases often require surgical intervention and the use of implantable replacement material and conduits. Traditional vascular grafts made of synthetic polymers, animal and cadaveric tissues, or aut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8bbe249e6578773ba42f7924f3adc8
https://doi.org/10.1161/circresaha.121.319984
https://doi.org/10.1161/circresaha.121.319984
Autor:
Lauren L Lohmer, Matthew R Clay, Kaleb M Naegeli, Qiuyi Chi, Joshua W Ziel, Elliott J Hagedorn, Jieun E Park, Ranjay Jayadev, David R Sherwood
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005786 (2016)
Invadopodia are specialized membrane protrusions composed of F-actin, actin regulators, signaling proteins, and a dynamically trafficked invadopodial membrane that drive cell invasion through basement membrane (BM) barriers in development and cancer.
Externí odkaz:
https://doaj.org/article/f44cb6e4aa5b4ce4bcd0920fecf8f975
Autor:
Tammy M. Havener, Christopher R. M. Asquith, Gary L. Johnson, William J. Zuercher, Tuomo Laitinen, Michael P. East, David C Morris, Kaleb M. Naegeli, David H. Drewry, Carrow I. Wells
Publikováno v:
Journal of Medicinal Chemistry. 62:4772-4778
We describe the design of a set of inhibitors to investigate the relationship between cyclin G associated kinase (GAK) and epidermal growth factor receptor (EGFR) in chordoma bone cancers. These compounds were characterized both in vitro and using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737bf7e7c8e9eb225acd64c9e2e58c05
https://doi.org/10.1021/acs.jmedchem.9b00350
https://doi.org/10.1021/acs.jmedchem.9b00350
Autor:
Kaleb M. Naegeli, Alexander O’Brien, Guney Bademci, Hui Yi Tee, Mustafa Tekin, Wen Yih Aw, Kathleen S. Arnos, Arti Pandya
Publikováno v:
Eur J Hum Genet
Hearing loss (HL) is one of the most common sensory defects, of which X-linked nonsyndromic hearing loss (NSHL) accounts for only 1-2%. While a COL4A6 variant has been reported in a single Hungarian family with NSHL associated with inner ear malforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af8d87f04b86b5bacb7b1b9f4542f42
https://europepmc.org/articles/PMC8738723/
https://europepmc.org/articles/PMC8738723/
Autor:
Stephan Lammel, Ulrich A. K. Betz, Sebald Verkuijl, Arne Wehling, Anastasiya Sybirna, Ângelo P. Matos, Michael S Ogden, Braden T. Tierney, Janneke van Blijswijk, Lena Eismann, Maike K. Hasslacher, Petra Wuelfroth, Tetyana Berbasova, Siegfried Neumann, Christian A. Tidona, Jhon R. Enterina, Christopher R. Vickery, Lian Zhu, Lorillee Tallorin, Lorenz Adlung, Josua Jordi, Amy C. Kauffman, Lisa M. Strittmatter, Kaleb M. Naegeli
Publikováno v:
Trends in Biotechnology
Over the past 350 years, Merck has developed science and technology especially in health care, life sciences, and performance materials. To celebrate so many productive years, Merck conducted a special expanded anniversary edition of the Innovation C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c5b6d676d2cdc18d2187c61cc3d038
https://hdl.handle.net/21.11116/0000-0005-495F-0
https://hdl.handle.net/21.11116/0000-0005-495F-0
Publikováno v:
Future Drug Discovery. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b03eab9b54d9c4c2df8513cc15fe94b
https://doi.org/10.4155/fdd-2019-0003
https://doi.org/10.4155/fdd-2019-0003
Autor:
Asquith Crm, William J. Zuercher, Tammy M. Havener, David H. Drewry, David C Morris, Michael P. East, Carrow I. Wells, Kaleb M. Naegeli, Tuomo Laitinen, Gary L. Johnson
We describe the design of a set of inhibitors to investigate the relationship between cyclin G associated kinase (GAK) and epidermal growth factor receptor (EGFR) in chordoma bone cancers. These compounds were characterized both in vitro and using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea03975bfcb3d12bbb7c8886b8c4356
Autor:
Joshua W. Ziel, Kaleb M. Naegeli, David R. Sherwood, Natasha S. Savage, Zheng Wang, Elliott J. Hagedorn, Qiuyi Chi, Lara M. Linden
Publikováno v:
Journal of Cell Biology
The Journal of Cell Biology
The Journal of Cell Biology
Stabilization of oscillatory UNC-40 clustering by its ligand UNC-6 directs localized F-actin generation and polarization of cells.
The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extrac
The receptor deleted in colorectal cancer (DCC) directs dynamic polarizing activities in animals toward its extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c06bdc744e39fee652ac42f5996d78
Autor:
Kenneth P. Nephew, Elizabeth Reilly, Christina S. Melki, Seungyoon Nam, Man-Wook Hur, Kaleb M. Naegeli, Curt Balch, Alan Hyslop, Brett Ballard
Publikováno v:
Cancer biologytherapy. 13(8)
Previously, we demonstrated potent antineoplastic activity of a distinctive histone deacetylase inhibitor (HDACI), AR42, against chemoresistant CP70 ovarian cancer cells in vitro and in vivo. Here, in follow-up to that work, we explored AR42 global m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5242db20d7b93b22572af612e1c70c
https://pubmed.ncbi.nlm.nih.gov/22549158
https://pubmed.ncbi.nlm.nih.gov/22549158