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Discovery of VU6024578/BI02982816: An mGlu 1 Positive Allosteric Modulator with Efficacy in Preclinical Antipsychotic and Cognition Models.

Autor: Reed CW; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Kalbfleisch JF; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Turkett JA; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Trombley TA; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Nastase AF; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Spearing PK; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Haymer DH; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Sarwar MM; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Quitalig M; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Dickerson JW, Blobaum AL; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Boutaud O; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Voehringer P; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, Biberach 88397, Germany., Schuelert N; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, Biberach 88397, Germany., Cho HP; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Niswender CM; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Rook JM; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Priepke H; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, Biberach 88397, Germany., Ursu D; Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, Biberach 88397, Germany., Conn PJ; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Melancon BJ; Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37067, Unites States., Lindsley CW

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Dec 26; Vol. 67 (24), pp. 22291-22312. Date of Electronic Publication: 2024 Dec 12.