Výsledky vyhledávání - "Kalback, Walter"

Akademický článek

The biochemical aftermath of anti-amyloid immunotherapy

Autor: Nicoll James AR, Masliah Eliezer, Luehrs Dean C, Patton R Lyle, Kalback Walter M, Kokjohn Tyler A, Daugs Ian D, Maarouf Chera L, Sabbagh Marwan N, Beach Thomas G, Castaño Eduardo M, Roher Alex E

Publikováno v: Molecular Neurodegeneration, Vol 5, Iss 1, p 39 (2010)

Abstract Background Active and passive immunotherapy in both amyloid-beta precursor protein (APP) transgenic mice and Alzheimer's Disease (AD) patients have resulted in remarkable reductions in amyloid plaque accumulation, although the degree of amyl

Externí odkaz: https://doaj.org/article/aacda5c61c1e44eba0eaaf1de88d63a2

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Akademický článek

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

Autor: Kalback Walter M, Patton R Lyle, Kokjohn Tyler A, Vidal Ruben, Spina Salvatore, Daugs Ian D, Maarouf Chera L, Luehrs Dean C, Walker Douglas G, Castaño Eduardo M, Beach Thomas G, Ghetti Bernardino, Roher Alex E

Publikováno v: Molecular Neurodegeneration, Vol 3, Iss 1, p 20 (2008)

Abstract Background Mutations in the presenilin (PSEN) genes are associated with early-onset familial Alzheimer's disease (FAD). Biochemical characterizations and comparisons have revealed that many PSEN mutations alter γ-secretase activity to promo

Externí odkaz: https://doaj.org/article/23e684679a654bf7a87e31ff82c530dd

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Neuropathological and biochemical assessments of an Alzheimer’s disease patient treated with the γ-secretase inhibitor semagacestat

Autor: Roher, Alex E, Maarouf, Chera L, Kokjohn, Tyler A, Whiteside, Charisse M, Kalback, Walter M, Serrano, Geidy, Belden, Christine, Liebsack, Carolyn, Jacobson, Sandra A, Sabbagh, Marwan N, Beach, Thomas G

Amyloid deposition has been implicated as the key determinant of Alzheimer's disease (AD) pathogenesis. Interventions to antagonize amyloid accumulation and mitigate dementia are now under active investigation. We conducted a combined clinical, bioch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::965a12943be79d4832e750b536801ddf
https://europepmc.org/articles/PMC4299724/

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Aβ peptides in human plasma and tissues and their significance for Alzheimer’s disease

We evaluated the amounts of amyloid beta (Abeta)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Abeta plasma levels and Alzheimer's disease (AD) pathology.Amyloid beta levels were measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80a8cf8163adeb9388cc22d11d87a9b6
https://europepmc.org/articles/PMC2663406/

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Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease

Autor: Van Vickle, Gregory D., Esh, Chera L., Kokjohn, Tyler A., Patton, R. Lyle, Kalback, Walter M., Luehrs, Dean C., Beach, Thomas G., Newel, Amanda J., Lopera, Francisco, Ghetti, Bernardino, Vidal, Rubén Alejandro, Castaño, Eduardo Miguel, Roher, Alex E.

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Presenilin (PS) mutations enhance the production of the Abeta42 peptide that is derived from the amyloid precursor protein (APP). The pathway(s) by which the Abeta42 species is preferentially produced has not been elucidated, nor is the mechanism by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::800d1e1a54f48392662a77b55602c3e7

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Altered APP Processing in PDAPP (Val717 → Phe) Transgenic Mice Yields Extended-Length Aβ Peptides

Autor: Esh, Chera, Patton, Lyle, Kalback, Walter, Kokjohn, Tyler A., Lopez, John, Brune, Daniel, Newell, Amanda J., Beach, Thomas, Schenk, Dale, Games, Dora, Paul, Steven, Bales, Kelly, Ghetti, Bernardino, Castaño, Eduardo Miguel, Roher, Alex E.

Central to the pathology of Alzheimer's disease (AD) is the profuse accumulation of amyloid-beta (Abeta) peptides in the brain of affected individuals, and several amyloid precursor protein (APP) transgenic (Tg) mice models have been created to mimic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3498::07dc82c60f6742281ebd0137573cb370

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