Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kalavathi Dasuri"'
Autor:
Linnea R Freeman, Le Zhang, Kalavathi Dasuri, Sun-Ok Fernandez-Kim, Annadora J Bruce-Keller, Jeffrey N Keller
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43193 (2012)
Mutations in amyloid precursor protein (APP) have been most intensely studied in brain tissue for their link to Alzheimer's disease (AD) pathology. However, APP is highly expressed in a variety of tissues including adipose tissue, where APP is also k
Externí odkaz:
https://doaj.org/article/f755f60a6fef4e98ab0261d797007271
Autor:
Malene Hansen, Carol Renneburg, Masaaki Komatsu, Jonathan Volkin, Sarah G Francisco, Paula Daza, Gemma Aragonès, Michael Workman, Allen Taylor, Opeoluwa Olukorede, Jose A. Rodriguez-Navarro, Helena Dominguez-Martín, Michael A. Brownlee, Caroline Kumsta, Wenxin Yang, Shun Kageyama, Xue Liang Du, Diego Ruano, Kalavathi Dasuri, Sheldon Rowan, Eloy Bejarano
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
Digital.CSIC. Repositorio Institucional del CSIC
Aging Cell
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
instname
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
Digital.CSIC. Repositorio Institucional del CSIC
Aging Cell
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of high levels of advanced glycation end products (AGEs), particularly upon aging. AGEs form when sugars or their metabolites react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a66753153f762501e685cfc80154b1f
Autor:
Kalavathi Dasuri, Jeffrey N. Keller, Jennifer K. Pepping, Sunita Gupta, Philipp E. Scherer, Annadora J. Bruce-Keller, Sun Ok Fernandez-Kim
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862:1228-1235
HIV protease inhibitors are key components of HIV antiretroviral therapies, which are fundamental in the treatment of HIV infection. However, the protease inhibitors are well-known to induce metabolic dysfunction which can in turn escalate the compli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d04adf55c27d8697a8bbd5ed6df65a
https://doi.org/10.1016/j.bbadis.2016.02.009
https://doi.org/10.1016/j.bbadis.2016.02.009
Autor:
Le Zhang, Jeffrey N. Keller, Sun O.K. Fernandez Kim, Annadora J. Bruce-Keller, Kalavathi Dasuri
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1862:274-283
Recent clinical and laboratory evidences suggest that high fat diet (HFD) induced obesity and its associated metabolic syndrome conditions promotes neuropathology in aging and age-related neurological disorders. However, the effects of high fat diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbd53438a54da508bae5a19620277f3
https://doi.org/10.1016/j.bbadis.2015.11.002
https://doi.org/10.1016/j.bbadis.2015.11.002
Autor:
Le Zhang, Jeffrey N. Keller, Annadora J. Bruce-Keller, Tina L. Beckett, Dana M. Niedowicz, M. Paul Murphy, Katharina Kohler, Sun-Ok Fernandez-Kim, Kalavathi Dasuri
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1865(9)
Alzheimer's disease (AD) is the most common age-related neurodegenerative disease, while obesity is a major global public health problem associated with the metabolic disorder type 2 diabetes mellitus (T2DM). Chronic obesity and T2DM have been identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2250c292c272f6c5d5d754764fb8e05f
https://pubmed.ncbi.nlm.nih.gov/31034991
https://pubmed.ncbi.nlm.nih.gov/31034991
Autor:
Maya Lotan-Pompan, Jedrzej Szymanski, Tal Korem, Naila Rabbani, Kerry A. Pierce, Adina Weinberger, Justin M. Scott, Christa Cassalman, Allen Taylor, Tali Avnit-Sagi, Xue Liang Du, Amy Deik, Eran Segal, Christina McGuire, Jason Szelog, Michael Brownlee, Shuhong Jiang, Sheldon Rowan, Kalavathi Dasuri, Donald Smith, Min Lee Chang, Paul J. Thornalley, James D. Baleja, Clary B. Clish, Ryoji Nagai
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(22)
Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and loss of photoreceptor cells. Epidemiologic studies indicate important contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e62f9710b3a4f23b2eb56772f2cb70
https://pubmed.ncbi.nlm.nih.gov/28507131
https://pubmed.ncbi.nlm.nih.gov/28507131
Publikováno v:
Free Radical Biology and Medicine. 62:170-185
Oxidative stress occurs in a variety of disease settings and is strongly linked to the development of neuron death and neuronal dysfunction. Cells are equipped with numerous pathways to prevent the genesis, as well as the consequences, of oxidative s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25127637467584de423edbd4911121b
https://doi.org/10.1016/j.freeradbiomed.2012.09.016
https://doi.org/10.1016/j.freeradbiomed.2012.09.016
Autor:
Jeffrey N. Keller, Anand R. Nair, Le Zhang, Linnea R. Freeman, Annadora J. Bruce-Keller, Sun-Ok Fernandez-Kim, Joseph Francis, Kalavathi Dasuri
Publikováno v:
Free Radical Biology and Medicine. 56:226-233
Nearly two-thirds of the population in the United States is overweight or obese, and this unprecedented level of obesity will undoubtedly have a profound impact on overall health, although little is currently known about the effects of obesity on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc069d97ec189fc47a498e5ade0b6cf
https://doi.org/10.1016/j.freeradbiomed.2012.08.577
https://doi.org/10.1016/j.freeradbiomed.2012.08.577
Autor:
Jeffrey N. Keller, Luke I. Szweda, Sun Ok Fernandez-Kim, Kalavathi Dasuri, Le Zhang, Annadora J. Bruce-Keller, Philip J. Ebenezer
Publikováno v:
Free Radical Biology and Medicine. 51:1727-1735
Intracellular proteins are degraded by a number of proteases including the ubiquitin-proteasome pathway (UPP). Impairments in the UPP occur during the aging of a variety of tissues, although little is known in regards to age-related alterations to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5251fb681256ad52b9616ba37411a667
https://doi.org/10.1016/j.freeradbiomed.2011.08.001
https://doi.org/10.1016/j.freeradbiomed.2011.08.001
Autor:
M. Paul Murphy, Adam M. Weidner, William R. Markesbery, Harry LeVine, Annadora J. Bruce-Keller, Jeffrey N. Keller, Sun Ok Fernandez-Kim, Kalavathi Dasuri, Philip J. Ebenezer, Le Zhang, Elena Gavilán
Publikováno v:
Journal of Alzheimer's Disease. 22:839-848
Recent studies have demonstrated a potential role for oligomeric forms of beta amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD), although it remains unclear which aspects of AD may be mediated by oligomeric Aβ. In the present study we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b23e75388349702cac472aeaede88f
https://doi.org/10.3233/jad-2010-101161
https://doi.org/10.3233/jad-2010-101161