Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B

Autor: Lv, Gang, Shi, Qiong, Zhang, Ting, Li, Jinhua, Long, Yan, Zhang, Wenhui, Choudhry, Namrta, Yang, Kevin, Li, Hongmei, Kalashova, Julia, Yang, Chenglu, Zhou, Xiaohu, Reddy, Mallu Chenna, Anantoju, Kishore Kumar, Zhang, Shenqiu, Zhang, Jing, Allen, Thaddeus D., Liu, Hong, Nimishetti, Naganna, Yang, Dun

Publikováno v: In Bioorganic & Medicinal Chemistry 15 February 2023 80

The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells.

Autor: Kalashova, Julia^1,2 (AUTHOR), Yang, Chenglu^1,2 (AUTHOR), Li, Hongmei^1,2 (AUTHOR), Long, Yan^1,2 (AUTHOR), Yu, Duo¹ (AUTHOR), Zhang, Ting^1,2 (AUTHOR), Liu, Xumei¹ (AUTHOR), Choudhry, Namrta^1,2 (AUTHOR), Shi, Qiong^1,2 (AUTHOR) qshi@anticancerbio.com, Allen, Thaddeus D.^1,2 (AUTHOR) qshi@anticancerbio.com

Publikováno v: PLoS ONE. 10/30/2023, Vol. 18 Issue 10, p1-19. 19p.

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Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment.

Autor: Li J; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Zhang T; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Shi Q; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Lv G; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Zhou X; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Choudhry N; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Kalashova J; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Yang C; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Li H; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Long Y; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Sakthivel B; Anticancer Bioscience (India), Hyderabad 500051, India., Nimishetti N; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Liu H; Anticancer Bioscience (US), South San Francisco, California 94080, United States., Allen TD; Anticancer Bioscience (US), South San Francisco, California 94080, United States., Zhang J; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China., Yang D; Chengdu Anticancer Bioscience, Chengdu 610000, China.; J. Michael Bishop Institute of Cancer Research, Chengdu 610000, China.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2023 Jul 21; Vol. 6 (8), pp. 1155-1163. Date of Electronic Publication: 2023 Jul 21 (Print Publication: 2023).