Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kalarickal V. Dileep"'
Autor:
Suryavathi Viswanadhapalli, Kalarickal V. Dileep, Kam Y.J. Zhang, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
Genes and Diseases, Vol 9, Iss 4, Pp 973-980 (2022)
Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pat
Externí odkaz:
https://doaj.org/article/11bfe3f1c6824917bcc51d2e42e1421d
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe a rationally designed first-in-class inhibitor of LIFR, EC359, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07cd43c1488eac97dde539175fac68e
https://doi.org/10.1158/1535-7163.c.6538359.v1
https://doi.org/10.1158/1535-7163.c.6538359.v1
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Supplementary Figure S1 shows SPR studies and Biotin EC359 pull down assays; Supplementary Figure S2 shows superimposition of hLIFR onto the mLIFR -hLIF complex; Supplementary Figure S3 shows sequence alignment of human (P42702) and mouse (P42703) LI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ee451be075a9d46cb02b1970ab4b84
https://doi.org/10.1158/1535-7163.22506315
https://doi.org/10.1158/1535-7163.22506315
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Supplementary methods section contain description of synthesis and characterization of EC330 and EC359, SPR studies, structural and sequence comparison of human and mouse LIFR, energy minimization of hLIFR, Protein and ligand preparation, molecular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f80ccb9927594621014305b0b7429d
https://doi.org/10.1158/1535-7163.22506309.v1
https://doi.org/10.1158/1535-7163.22506309.v1
Autor:
Panagiota G.V. Liggri, Alfonso Pérez-Garrido, Katerina E. Tsitsanou, Kalarickal V. Dileep, Antonios Michaelakis, Dimitrios P. Papachristos, Horacio Pérez-Sánchez, Spyros E. Zographos
Publikováno v:
Insect Biochemistry and Molecular Biology. 157:103961
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b9576369a49ce1146cd183769600aeb
https://doi.org/10.1016/j.ibmb.2023.103961
https://doi.org/10.1016/j.ibmb.2023.103961
Publikováno v:
Journal of Cellular Biochemistry. 122:787-800
Missense mutations of human choline acetyltransferase (CHAT) are mainly associated with congenital myasthenic syndrome (CMS). To date, several pathogenic mutations have been reported, but due to the rarity and genetic complexity of CMS and difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824bc4e4e4288d452ee385998899ff3d
https://doi.org/10.1002/jcb.29913
https://doi.org/10.1002/jcb.29913
Autor:
Kalarickal V. Dileep, Minoru Yoshida, Divya M. Sivaraman, Akiko Nakata, Miyuki Kato-Murayama, Akihiro Ito, Kam Y. J. Zhang, Jay W. Shin, Mikako Shirouzu, Naoki Sakai, Kentaro Ihara
Publikováno v:
International Journal of Biological Macromolecules. 170:415-423
Alzheimer's disease (AD), a common chronic neurodegenerative disease, has become a major public health concern. Despite years of research, therapeutics for AD are limited. Overexpression of secretory glutaminyl cyclase (sQC) in AD brain leads to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cc1608d4d8f5c0ddaa2862df99f5ea
https://doi.org/10.1016/j.ijbiomac.2020.12.118
https://doi.org/10.1016/j.ijbiomac.2020.12.118
Autor:
Jianming Wang, Xuetian Yue, Fangnan Wu, Wenwei Hu, Suryavathi Viswanadhapalli, Kam Y. J. Zhang, Gulzar Ahmed, Klaus Nickisch, Zhaohui Feng, Kaitlin Kim, Ratna K. Vadlamudi, Kalarickal V. Dileep, Bindu Santhamma
Publikováno v:
Journal of Molecular Cell Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414c3044b845ad65fe0e95bc561b0b1b
https://doi.org/10.1093/jmcb/mjaa008
https://doi.org/10.1093/jmcb/mjaa008
Autor:
Mukesh Kumar, Vinod Scaria, Kavita Pandhare, Kalarickal V. Dileep, Mukta Poojary, B K Binukumar, Aditi Mhaske, Kam Y. J. Zhang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2347-2356 (2020)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
ATP7A is a critical copper transporter involved in Menkes Disease, Occipital horn Syndrome and X-linked distal spinal muscular atrophy type 3 which are X linked genetic disorders. These are rare diseases and their genetic epid
ATP7A is a critical copper transporter involved in Menkes Disease, Occipital horn Syndrome and X-linked distal spinal muscular atrophy type 3 which are X linked genetic disorders. These are rare diseases and their genetic epid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef5df33c412ea7e357918df38ea783f
https://doi.org/10.1016/j.csbj.2020.08.021
https://doi.org/10.1016/j.csbj.2020.08.021
Autor:
Remya Chandran, Kalarickal V. Dileep
Publikováno v:
Chemical biologydrug designREFERENCES. 98(5)
Secretory glutaminyl cyclase (sQC) plays an important role in the formation of the pyroglutamate-amyloid beta (pGlu-Aβ) peptide, one of the most abundant variants of Aβ found in the Alzheimer's disease (AD) brain. This post-translationally modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2886c979a7bd7ae1c6fec91182dba4e
https://pubmed.ncbi.nlm.nih.gov/34423556
https://pubmed.ncbi.nlm.nih.gov/34423556