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Severe White Matter Astrocytopathy in CADASIL

Autor: Hase, Y, Chen, A, Bates, LL, Craggs, LJL, Yamamoto, Y, Gemmell, E, Oakley, AE, Korolchuk, VI, Kalaria, RN

Objectives Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterised by strategic white matter (WM) hyperintensities on MRI. Pathological features include WM degeneration, arteriolosclerosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ee31043941130e6ca92abd7edc546c4a
https://eprints.whiterose.ac.uk/131114/1/Hase_BrainPathol_2018_May14_SevereAstrocytopathyCADASIL.pdf

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Stroke genomics in people of African ancestry: charting new paths

Autor: Akinyemi, RO, Ovbiagele, B, Gebreziabher, M, Warth, S, Lackland, D, Akpalu, A, Sagoe, K, Owolabi, L, Sarfo, F, Obiako, R, Tiwari, H, Arnett, D, Kalaria, RN, Melikam, E, Arulogun, O, Ogunniyi, A, Owolabi, MO

Publikováno v: Cardiovascular Journal of Africa

One in six people worldwide will experience a stroke in his/her lifetime. While people in Africa carry a disproportionately higher burden of poor stroke outcomes, compared to the rest of the world, the exact contribution of genomic factors to this di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3628568a67baaad69f4983539c6355b
http://europepmc.org/articles/PMC4557488

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Microvascular Pathology and Morphometrics of Sporadic and Hereditary Small Vessel Diseases of the Brain

Autor: Craggs, LJL, Yamamoto, Y, Deramecourt, V, Kalaria, RN

Publikováno v: Brain Pathology (Zurich, Switzerland)

Small vessel diseases (SVDs) of the brain are likely to become increasingly common in tandem with the rise in the aging population. In recent years, neuroimaging and pathological studies have informed on the pathogenesis of sporadic SVD and several s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bdcac6c9ded3931a44d8f49a23f71128
http://europepmc.org/articles/PMC4228759

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Clusterin/Apolipoprotein J immunoreactivity is associated with white matter damage in cerebral small vessel diseases

Autor: Craggs, L, Taylor, J, Slade, JY, Chen, A, Hagel, C, Kuhlenbaeumer, G, Borjesson-Hanson, A, Viitanen, M, Kalimo, H, Deramecourt, V, Oakley, AE, Kalaria, RN

Aim: Brain clusterin is known to be associated with the amyloid‐β deposits in Alzheimer's disease (AD). We assessed the distribution of clusterin immunoreactivity in cerebrovascular disorders, particularly focusing on white matter changes in small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5aefe12a7b9311b773c9743680e0cb56
https://eprints.whiterose.ac.uk/131121/1/Craggs_2016_NAN_ClusterinSVD.pdf

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Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

Autor: Craggs, LJL, Fenwick, R, Oakley, AE, Ihara, M, Kalaria, RN

Aims: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is identified by aggregates of NOTCH3 extracellular domain (N3ECD) along capillaries and the deposition of granular osmiophilic material (GOM).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::78c8db43cb1e8a43d163526d44da68ad
https://eprints.whiterose.ac.uk/131124/1/Craggs_2015_Nan_PDGFRbetaCADASIL.pdf

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White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

Autor: Craggs, LJL, Yamamoto, Y, Ihara, M, Fenwick, R, Burke, M, Oakley, AE, Roeber, S, Duering, M, Kretzschmar, H, Kalaria, RN

Background; Magnetic resonance imaging indicates diffuse white matter (WM) changes are associated with cognitive impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We examined whether t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5c2258cb72ade6f886d3e85aee9109a5
https://eprints.whiterose.ac.uk/131125/1/Craggs_2014_NaN_WMpatholFrontalLobeDisconCADASIL.pdf

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Autor: Farkas, E, De Jong, GI, Apro, E, De Vos, RAI, Steur, ENHJ, Luiten, PGM, Kalaria, RN, Ince, P

Publikováno v: Vascular factors in Alzheimer's disease, 72-82
STARTPAGE=72;ENDPAGE=82;TITLE=Vascular factors in Alzheimer's disease

The brain, as an intensely active organ, is highly dependent on a sufficient nutrient and oxygen availability in order to reach its optimal working capacity. It is well known that the vital supply of energy substrates Is provided by the circulatory s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b683e7255c4857bd78d140d55c7bed
https://research.rug.nl/en/publications/132da2e7-b393-4150-8dd4-224cd673b16c

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