Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kalani Halemano"'
Autor:
Kira Rubtsova, Anatoly V Rubtsov, Kalani Halemano, Sam X Li, John W Kappler, Mario L Santiago, Philippa Marrack
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166322 (2016)
Knowledge of the processes that underlie IgG subclass switching could inform strategies designed to counteract infections and autoimmunity. Here we show that TLR7 ligands induce subsets of memory CD4 and CD8 T cells to secrete interferon γ (IFNγ) i
Externí odkaz:
https://doaj.org/article/3291481214dc474f89bec8bd87f8082c
Autor:
Kalani Halemano, Bradley S Barrett, Sam X Li, Michael S Harper, Diana S Smith, Karl J Heilman, Mario L Santiago
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60500 (2013)
Understanding the host genetics of the immune response in retrovirus infection models could provide insights for basic HIV vaccine discovery. In Friend retrovirus (FV) infection of mice, Fv1 differentially inhibits N-tropic versus B-tropic FV infecti
Externí odkaz:
https://doaj.org/article/57cde0d6dcd2499eab7aae2adf100672
Autor:
Karl J. Heilman, Michael S. Harper, Yaqiong Wang, Miki Katuwal, Kimberly Schmitt, Kejun Guo, Mario L. Santiago, Edward B. Stephens, Takeo Kuwata, Kalani Halemano
Publikováno v:
Immunogenetics. 67:355-370
B cell functional defects are associated with delayed neutralizing antibody development in pathogenic lentivirus infections. However, the timeframe for alterations in the antibody repertoire and somatic hypermutation (SHM) remains unclear. Here, we u
Autor:
Kejun Guo, Mario L. Santiago, Kalani Halemano, Edward B. Stephens, Miki Katuwal, Kimberly Schmitt, Yaqiong Wang
Publikováno v:
Virology. :532-544
The APOBEC3 (A3) deaminases are retrovirus restriction factors that were proposed as inhibitory components of HIV-1 gene therapy vectors. However, A3 mutational activity may induce undesired genomic damage and enable HIV-1 to evade drugs and immune r
Autor:
Kalani Halemano, Kim J. Hasenkrug, Mario L. Santiago, Diana S. Smith, Kejun Guo, Bradley S. Barrett, Karl J. Heilman
Publikováno v:
Proceedings of the National Academy of Sciences. 111:7759-7764
Somatic hypermutation (SHM) is an integral process in the development of high-affinity antibodies that are important for recovery from viral infections and vaccine-induced protection. Ig SHM occurs predominantly in germinal centers (GC) via the enzym
Autor:
Amanda K. Steele, Michael S. Harper, Kejun Guo, Kalani Halemano, Sam X. Li, Bradley S. Barrett, Karl J. Heilman, Mario L. Santiago, Robert H. Silverman
Publikováno v:
Virology. 443(1):134-142
Ribonuclease L (RNase L) is a type I interferon regulated factor that can significantly inhibit retroviruses in vitro and may activate cytoplasmic sensing pathways to augment adaptive immunity. However, the antiretroviral activity of RNase L remains
Autor:
Bradley S. Barrett, Karl J. Heilman, Sam X. Li, Kalani Halemano, Mario L. Santiago, Kejun Guo, Michael S. Harper
Publikováno v:
Immunologic Research. 55:249-260
Major conceptual roadblocks impede the development of an HIV-1 vaccine that can stimulate a potent neutralizing antibody response. Animal models that support HIV-1 replication and allow for host genetic manipulation would be an ideal platform for tes
Publikováno v:
Letters in Drug Design & Discovery. 5:369-376
Publikováno v:
Journal of virology. 89(7)
Antiretroviral neutralizing antibody (NAb) responses are often evaluated in the absence of Fc-dependent immune effectors. In murine Friend retrovirus infection, Apobec3/Rfv3 promotes a potent polyclonal NAb response. Here, we show that the Apobec3/Rf
Autor:
Philippa Marrack, John W. Kappler, Kalani Halemano, Sam X. Li, Anatoly V. Rubtsov, Mario L. Santiago, Kira Rubtsova
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166322 (2016)
PLoS ONE
PLoS ONE
Knowledge of the processes that underlie IgG subclass switching could inform strategies designed to counteract infections and autoimmunity. Here we show that TLR7 ligands induce subsets of memory CD4 and CD8 T cells to secrete interferon γ (IFNγ) i