Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kalai Selvi Shanmugam"'
Autor:
Michael Hoffmeister, Hermann Brenner, Kalai Selvi Shanmugam, Barbara Burwinkel, Jenny Chang-Claude
Publikováno v:
Carcinogenesis. 28:1914-1917
The Wnt-beta-catenin pathway plays a central role in colorectal tumorigenesis. Frizzled-related protein (FRZB, also termed secreted frizzled-related protein 3, sFRP3) antagonizes the signaling of wingless (Wnt) ligands through the frizzled membrane-b
Autor:
Barbara Burwinkel, Bernd Frank, Hermann Brenner, Lars Beckmann, Kari Hemminki, Michael Hoffmeister, Jenny Chang-Claude, Kalai Selvi Shanmugam
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 15:2002-2005
The tumor necrosis factor–related apoptosis-inducing ligand receptor modulates apoptotic response by binding to the proapoptotic death receptor 4 (DR4). Perturbed apoptosis due to missense alterations in the candidate tumor suppressor gene DR4 lead
Autor:
James H. Resau, Tad Guszczynski, Christina M. Hughes, Terry D. Copeland, Matthew Meyerson, Suraj J. Nannepaga, Orit Rozenblatt-Rosen, Kalai Selvi Shanmugam
Publikováno v:
Molecular and Cellular Biology. 25:612-620
Parafibromin, the product of the HRPT2 (hyperparathyroidism-jaw tumor syndrome 2) tumor suppressor gene, is the human homologue of yeast Cdc73, part of the yeast RNA polymerase II/Paf1 complex known to be important for histone modification and connec
Autor:
Orit Rozenblatt-Rosen, Arindam Bhattacharjee, Kalai Selvi Shanmugam, Stuart S. Levine, Graham F. Kay, D. Neil Hayes, Jeffrey C. Lee, Terry D. Copeland, Christina M. Hughes, Christine A. Biondi, Thomas A. Milne, Nicholas K. Hayward, Jay L. Hess, Matthew Meyerson
Publikováno v:
Molecular Cell. 13(4):587-597
The cellular function of the menin tumor suppressor protein, product of the MEN1 gene mutated in familial multiple endocrine neoplasia type 1, has not been defined. We now show that menin is associated with a histone methyltransferase complex contain
Autor:
Bernd Frank, Rita K. Schmutzler, Barbara Burwinkel, Claus R. Bartram, Kalai Selvi Shanmugam, Kari Hemminki, Barbara Wappenschmidt, Marion Kiechle, Alfons Meindl, Christian Sutter
Publikováno v:
BMC Cancer, Vol 6, Iss 1, p 268 (2006)
BMC Cancer
BMC Cancer
Background The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alte
Autor:
Barbara Wappenschmidt, Bernd Frank, Peter Bugert, Michael Untch, Rita K. Schmutzler, Barbara Burwinkel, Rüdiger Klaes, Alfons Meindl, Claus R. Bartram, Kalai Selvi Shanmugam, Kari Hemminki
Publikováno v:
Carcinogenesis. 26(11)
Dysregulation of apoptosis plays a crucial role in carcinogenesis. Tumour necrosis factor-related apoptosis-inducing ligand stimulates the extrinsic apoptotic pathway by binding to death receptor 4 (DR4). Thus, genetic alterations within the candidat
Autor:
Natasha J. Caplen, Christina M. Hughes, Francis S. Collins, Kalai Selvi Shanmugam, Tyra G. Wolfsberg, Arindam Bhattacharjee, Jeffrey C. Lee, Orit Rozenblatt-Rosen, Peter C. Scacheri, Lowell Umayam, Matthew Meyerson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(7)
RNA interference (RNAi) mediated by short interfering RNAs (siRNAs) is a widely used method to analyze gene function. To use RNAi knockdown accurately to infer gene function, it is essential to determine the specificity of siRNA-mediated RNAi. We hav