Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kal Ramnarayan"'
Autor:
Martha Mutomba, Jing Wang, Sergei Mailiartchouk, Tom Brady, Darryl Rideout, Christina Niemeyer, Hengyi Zhu, Cindy Fisher, Seymour Mong, Kal Ramnarayan
Publikováno v:
The Scientific World Journal, Vol 1, Pp 107-107 (2001)
Externí odkaz:
https://doaj.org/article/6a0522389a53490fa8fa89937ced89f9
Autor:
K. Darrell Berlin, Richard A. Bunce, Baskar Nammalwar, William W. Barrow, Shankari Mylvaganam, Philip C. Bourne, Christina R. Bourne, Esther W. Barrow, Nancy Wakeham, Kal Ramnarayan
Publikováno v:
ChemMedChem. 7:1974-1982
A series of (±)-6-alkyl-2,4-diaminopyrimidine-based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against Bacillus anthracis and Staphylococcus aureus. Biological studies reveal attenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f81fbb16ff5a056bd7eb4a97886538
https://doi.org/10.1002/cmdc.201200291
https://doi.org/10.1002/cmdc.201200291
Autor:
Mark D. Shenderovich, Cindy L. Fisher, Vladimir Tseitin, Michael J. Dudek, S. McDonald, Muthuchidambaram Prabhakaran, Kal Ramnarayan, Shankari Mylvaganam, R. Kodandapani, Jian Hua Zheng, G. Raghunathan
Publikováno v:
Current Proteomics. 2:233-258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0140d2dfb44651a02baa4d86595d13cd
https://doi.org/10.2174/157016405774641156
https://doi.org/10.2174/157016405774641156
Publikováno v:
Protein Science. 14:1870-1878
We have identified a rare HIV-1 protease (PR) mutation, I47A, associated with a high level of resistance to the protease inhibitor lopinavir (LPV) and with hypersusceptibility to the protease inhibitor saquinavir (SQV). The I47A mutation was found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49888d0cdb20ad597630bd35c036989
https://doi.org/10.1110/ps.051347405
https://doi.org/10.1110/ps.051347405
Publikováno v:
Current Proteomics. 1:145-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f14c5e048ce2fbde596d54b19627cef
https://doi.org/10.2174/1570164043379334
https://doi.org/10.2174/1570164043379334
Publikováno v:
Protein Science. 12:1706-1718
Mutations in HIV-1 drug targets lead to resistance and consequent therapeutic failure of antiretroviral drugs. Phenotypic resistance assays are time-consuming and costly, and genotypic rules-based interpretations may fail to predict the effects of mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9dbc1db8d634722a4c6b016aec7f1e
https://doi.org/10.1110/ps.0301103
https://doi.org/10.1110/ps.0301103
Publikováno v:
Drug Discovery Today. 7:1214-1220
Large-scale comparative analysis of drug-target polymorphism structures enables the rational design of next generation 'super drugs'--drugs that are less prone to development of drug resistance or that work for the largest possible fraction of the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dadce748d481d41f476f71ad60bbf2
https://doi.org/10.1016/s1359-6446(02)02514-x
https://doi.org/10.1016/s1359-6446(02)02514-x
Autor:
Edward T. Maggio, Kal Ramnarayan
Publikováno v:
Trends in Biotechnology. 19:266-272
The mapping of the human genome was completed earlier this year and efforts are underway to understand the role of gene products (i.e. proteins) in biological pathways and human disease and to exploit their functional roles to derive protein therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfddcdc0b1469c20f3254337a25efafb
https://doi.org/10.1016/s0167-7799(01)01666-3
https://doi.org/10.1016/s0167-7799(01)01666-3
Publikováno v:
Journal of Computational Chemistry. 19:548-573
A protein energy surface is constructed. Validation is through applications of global energy minimization to surface loops of protein crystal structures. For 9 of 10 predictions, the native backbone conformation is identified correctly. Electrostatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c30e9c13b7a1a54fe36ab55d549867d
https://doi.org/10.1002/(sici)1096-987x(19980415)19:5<548::aid-jcc7>3.0.co
https://doi.org/10.1002/(sici)1096-987x(19980415)19:5<548::aid-jcc7>3.0.co
Autor:
Christina R. Bourne, Esther W. Barrow, Vladimir Tseitin, Kal Ramnarayan, K. Darrell Berlin, William W. Barrow, Philip C. Bourne, Richard A. Bunce, Nancy Wakeham, Baskar Nammalwar, Shankari Mylvaganam
Background: Bacterial resistance to antibiotic therapies is increasing and new treatment options are badly needed. There is an overlap between these resistant bacteria and organisms classified as likely bioterror weapons. For example, Bacillus anthra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4365355cfa9cfeee643025baf14bbf
https://europepmc.org/articles/PMC3530638/
https://europepmc.org/articles/PMC3530638/
