CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.

Autor: Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Hartweger H; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Loewe M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., van Schooten J; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Ramos V; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Oliveira TY; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Nishimura Y; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Koranda NS; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Wall A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA., Yao KH; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Poston D; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Gazumyan A; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Wiatr M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Horning M; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Hoffmann MAG; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Yang Z; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Abernathy ME; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Dam KA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gao H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kakutani LM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Pavlovitch-Bedzyk AJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Howarth M; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., McGuire AT; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA., Stamatatos L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Global Health, University of Washington, Seattle, WA 98195, USA., Martin MA; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Nussenzweig MC; Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.; Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Publikováno v: Science immunology [Sci Immunol] 2023 Feb 17; Vol. 8 (80), pp. eade6364. Date of Electronic Publication: 2023 Feb 10.

Insights into the C-terminal domain of apolipoprotein E from chimera studies with apolipophorin III.

Autor: Horn JVC; Department of Chemistry and Biochemistry, California State University Long Beach, 1250 Bellflower Blvd., Long Beach, CA, 90840, USA., Kakutani LM; Department of Chemistry and Biochemistry, California State University Long Beach, 1250 Bellflower Blvd., Long Beach, CA, 90840, USA., Narayanaswami V; Department of Chemistry and Biochemistry, California State University Long Beach, 1250 Bellflower Blvd., Long Beach, CA, 90840, USA., Weers PMM; Department of Chemistry and Biochemistry, California State University Long Beach, 1250 Bellflower Blvd., Long Beach, CA, 90840, USA. paul.weers@csulb.edu.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2023 Jan; Vol. 478 (1), pp. 173-183. Date of Electronic Publication: 2022 Jun 28.

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models.

Autor: Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., van Doremalen N; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA., Greaney AJ; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Genome Sciences and Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA., Andersen H; BIOQUAL, Rockville, MD, USA., Sharma A; BIOQUAL, Rockville, MD, USA., Starr TN; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Department of Genome Sciences and Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Fan C; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Schulz JE; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA., Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kakutani LM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Saturday G; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA., Lee YE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gao H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Jette CA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Lewis MG; BIOQUAL, Rockville, MD, USA., Tan TK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK., Townsend AR; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Chinese Academy of Medical Sciences, Oxford Institute, University of Oxford, Oxford OX3 9DS, UK., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98109, USA., Munster VJ; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Aug 05; Vol. 377 (6606), pp. eabq0839. Date of Electronic Publication: 2022 Aug 05.

Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env.

Autor: Escolano A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gautam R; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., DeLaitsch AT; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Abernathy ME; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Yang Z; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Wang H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Hoffmann MAG; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Nishimura Y; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Wang Z; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Koranda N; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kakutani LM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gao H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Raina H; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Cipolla M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Irvine DJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Silva M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA., Martin MA; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Nov 24; Vol. 13 (621), pp. eabk1533. Date of Electronic Publication: 2021 Nov 24.

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.

Autor: Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Lee YE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Hoffman PR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Ou S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kakutani LM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Wu HJ; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Howarth M; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., West AP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Jan 05. Date of Electronic Publication: 2021 Jan 05.