Freshly Isolated Hepatocytes from Chimeric Humanized Liver Mice for the In Vitro Assessment of Drug Metabolism, Inhibition/Induction, and Safety Studies.

Autor: Kakuni M; PhoenixBio Co., Ltd., Kagamiyama, Higashi-Hiroshima, Japan.; KMT Hepatech Inc., Edmonton, Alberta, Canada.

Publikováno v: Current protocols [Curr Protoc] 2022 May; Vol. 2 (5), pp. e429.

Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.

Autor: Higashi-Kuwata N; Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan., Hayashi S; Department of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Kumamoto H; Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama, Japan., Ogata-Aoki H; Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Das D; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Venzon D; Biostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hattori SI; Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan., Bulut H; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Hashimoto M; Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan., Otagiri M; Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan., Takamune N; Kumamoto Innovative Development Organization, Kumamoto University, Kumamoto, Japan., Kishimoto N; Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan., Davis DA; Viral Oncology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Misumi S; Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan., Kakuni M; PhoenixBio Co., Ltd., Higashi-hiroshima, Hiroshima, Japan., Tanaka Y; Department of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Mitsuya H; Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Department of Clinical Sciences, Kumamoto University Hospital, Kumamoto, Japan. Electronic address: hmitsuya@hosp.ncgm.go.jp.

Publikováno v: Journal of hepatology [J Hepatol] 2021 May; Vol. 74 (5), pp. 1075-1086. Date of Electronic Publication: 2020 Dec 15.

Evaluation of Interfering RNA Efficacy in Treating Hepatitis B: Is It Promising?

Autor: Angelice, Giovana Paula¹ (AUTHOR), Roque, Pedro Henrique¹ (AUTHOR) roquephr@gmail.com, Valente, Gabriel¹ (AUTHOR) liviafiocruz@gmail.com, Galvão, Krishna¹ (AUTHOR), Villar, Livia Melo¹ (AUTHOR), Mello, Vinicius Motta¹ (AUTHOR), Mello, Francisco C. A.¹ (AUTHOR), Lago, Bárbara Vieira¹ (AUTHOR)

Publikováno v: Viruses (1999-4915). Nov2024, Vol. 16 Issue 11, p1710. 17p.

Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.

Autor: Sanoh S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan., Naritomi Y; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan., Kitamura S; Analysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc, Tsukuba, Japan., Shinagawa A; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan., Kakuni M; Study Service Dept, PhoenixBio, Co., Ltd, Tsukuba, Japan., Tateno C; R&D Dept, PhoenixBio, Co., Ltd, Higashi-Hiroshima, Japan.; Research Center for Hepatology and Gastroenterology, Hiroshima University, Higashi-Hiroshima, Japan., Ohta S; Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.; School of Pharmaceutical Sciences, Hiroshima University, Hiroshima, Japan.; Wakayama Medical University, Wakayama, Japan.

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Nov; Vol. 50 (11), pp. 1370-1379. Date of Electronic Publication: 2020 Jun 05.

High-Throughput Screening of Antiviral Compounds Using a Recombinant Hepatitis B Virus and Identification of a Possible Infection Inhibitor, Skimmianine.

Autor: Yoshita, Mika^1,2 (AUTHOR) k.murai.0612@gmail.com, Funaki, Masaya¹ (AUTHOR) funachan1@gmail.com, Shimakami, Tetsuro¹ (AUTHOR) m.kakuya.39@gmail.com, Kakuya, Masaki¹ (AUTHOR) yumeoi0812@yahoo.co.jp, Murai, Kazuhisa² (AUTHOR) asu317tama@stu.kanazawa-u.ac.jp, Sugimoto, Saiho¹ (AUTHOR) skawase.0806@gmail.com, Kawase, Shotaro¹ (AUTHOR) matsumorikoji@gmail.com, Matsumori, Koji¹ (AUTHOR) barutoest57@gmail.com, Kawane, Taro¹ (AUTHOR) rbgqy690@gmail.com, Nishikawa, Tomoki¹ (AUTHOR) liyingyi@staff.kanazawa-u.ac.jp, Nakamura, Asuka² (AUTHOR) reonandesu@gmail.com, Suzuki, Reo² (AUTHOR) atsuya.98617@gmail.com, Ishida, Atsuya² (AUTHOR) lux67ufrv@stu.kanazawa-u.ac.jp, Kawasaki, Narumi² (AUTHOR) ysa2601@stu.kanazawa-u.ac.jp, Sato, Yuga² (AUTHOR) mhonda@m-kanazawa.jp, Li, Ying-Yi¹ (AUTHOR) ariunasumi1972@gmail.com, Sumiyadorj, Ariunaa¹ (AUTHOR) nio@m-kanazawa.jp, Nio, Kouki¹ (AUTHOR) hajimetakatori@gmail.com, Takatori, Hajime¹ (AUTHOR) kawaguchi@m-kanazawa.jp, Kawaguchi, Kazunori¹ (AUTHOR) kkuroki27@gmail.com

Publikováno v: Viruses (1999-4915). Aug2024, Vol. 16 Issue 8, p1346. 17p.