Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kakeru, Ozaki"'
Autor:
Shinsuke Ochiai, Kazuya Tokumura, Gyujin Park, Kakeru Ozaki, Tetsuhiro Horie, Takanori Yamada, Sayuki Iwahashi, Kaname Ohta, Hiroki Fusawa, Yasuka Okayama, Katsuyuki Kaneda, Takashi Iezaki, Eiichi Hinoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 1-5 (2021)
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailt
Externí odkaz:
https://doaj.org/article/8bb19e32b3b8492a93d071b9d27caabe
Autor:
Takashi Iezaki, Tetsuhiro Horie, Kazuya Fukasawa, Makoto Kitabatake, Yuka Nakamura, Gyujin Park, Yuki Onishi, Kakeru Ozaki, Takashi Kanayama, Manami Hiraiwa, Yuka Kitaguchi, Katsuyuki Kaneda, Takayuki Manabe, Yasuhito Ishigaki, Mutsuhito Ohno, Eiichi Hinoi
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Summary: The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs
Externí odkaz:
https://doaj.org/article/a74140fb7e634b20b5faa27345d65c2c
Autor:
Manami Hiraiwa, Kakeru Ozaki, Takanori Yamada, Takashi Iezaki, Gyujin Park, Kazuya Fukasawa, Tetsuhiro Horie, Hikari Kamada, Kazuya Tokumura, Mei Motono, Katsuyuki Kaneda, Eiichi Hinoi
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the pathogenesis of various diseases, including cancer, obesity, and cardiovascular disease. Bone homeostasis is maintained by the actions of bone-resorbing osteoclasts and
Externí odkaz:
https://doaj.org/article/77d5728b82864ecfb103a2d6f83a5a78
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 216-223 (2016)
We previously demonstrated a marked upregulation in the bone morphogenic protein (BMP)/growth differentiation factor (GDF) family member, GDF5, which is capable of promoting brown adipogenesis, in brown adipose tissue (BAT) of obese mice. In this stu
Externí odkaz:
https://doaj.org/article/cf484434d96a4c9f8b6ef16305eab2a6
Autor:
Kakeru Ozaki, Maika Okamoto, Kazuya Fukasawa, Takashi Iezaki, Yuki Onishi, Yukio Yoneda, Minoru Sugiura, Eiichi Hinoi
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 1, Pp 72-77 (2015)
Although β-cryptoxanthin, a xanthophyll carotenoid, has been shown to exert an anabolic effect on bone calcification, little attention has been paid thus far to the precise mechanism of bone remodeling. Daily oral administration of β-cryptoxanthin
Externí odkaz:
https://doaj.org/article/a7bcf46d52404deb841aa4afe209067f
Autor:
Kazuya Tokumura, Eiichi Hinoi, Katsuyuki Kaneda, Sayuki Iwahashi, Kaname Ohta, Tetsuhiro Horie, Takashi Iezaki, Gyujin Park, Shinsuke Ochiai, Hiroki Fusawa, Yasuka Okayama, Kakeru Ozaki, Takanori Yamada
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 1-5 (2021)
Bone remodeling is sophisticatedly regulated by two different cell types: bone-resorbing osteoclasts and bone-forming osteoblasts. Hochu-Ekki-To, a Japanese traditional herbal medicine, is commonly used for the treatment of chronic diseases or frailt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8b3a61f05bb5662ca2889448198cc3
https://doi.org/10.1016/j.jphs.2020.09.007
https://doi.org/10.1016/j.jphs.2020.09.007
Autor:
Manami Hiraiwa, Makoto Kitabatake, Katsuyuki Kaneda, Takayuki Manabe, Gyujin Park, Takashi Iezaki, Yuka Kitaguchi, Kazuya Fukasawa, Mutsuhito Ohno, Eiichi Hinoi, Takashi Kanayama, Yuki Onishi, Tetsuhiro Horie, Yuka Nakamura, Yasuhito Ishigaki, Kakeru Ozaki
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Stem Cell Reports, Vol 11, Iss 1, Pp 228-241 (2018)
Summary The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dda4619f6033f9a6cc306811c31388
https://doi.org/10.1016/j.stemcr.2018.05.020
https://doi.org/10.1016/j.stemcr.2018.05.020
Autor:
Gyujin Park, Yuka Kitaguchi, Kazuya Fukasawa, Yuki Onishi, Manami Hiraiwa, Takashi Iezaki, Tetsuhiro Horie, Katsuyuki Kaneda, Takashi Kanayama, Eiichi Hinoi, Kakeru Ozaki
Publikováno v:
Pharmacology. 101:64-71
The availability of amino acid in the brown adipose tissue (BAT) has been shown to be altered under various conditions; however, little is known about the possible expression and pivotal role of amino acid transporters in BAT under physiological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb5b995b818dfc4926289eb11533afdc
https://doi.org/10.1159/000480405
https://doi.org/10.1159/000480405
Autor:
Tetsuhiro Horie, Takashi Iezaki, Takashi Kanayama, Gyujin Park, Minoru Sugiura, Maika Okamoto, Kakeru Ozaki, Yuki Onishi, Kazuya Fukasawa, Eiichi Hinoi
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 81:1014-1017
β-cryptoxanthin, a xanthophyll carotenoid, exerts preventive effects on various lifestyle-related diseases. Here, we found that daily oral administration of β-cryptoxanthin significantly ameliorated the development of tactile allodynia following sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7d6675725678221c68fccfb12f3e46
https://doi.org/10.1080/09168451.2017.1280661
https://doi.org/10.1080/09168451.2017.1280661
Autor:
Shu Takeda, Takashi Iezaki, Ryota Nakazato, Shigeki Shimba, Ayumi Kodama, Michihiro Mieda, Kakeru Ozaki, Saki Nakamura, Cheng Xu, Daisuke Yamada, Hajime Tei, Eiichi Hinoi, Yukio Yoneda, Koichi Fujikawa, Kazuya Fukasawa, Takeshi Takarada, Rika Numano, Akiko Hida, Hiroki Ochi
Publikováno v:
Journal of Bone and Mineral Research. 32:872-881
We have previously shown that endochondral ossification is finely regulated by the Clock system expressed in chondrocytes during postnatal skeletogenesis. Here we show a sophisticated modulation of bone resorption and bone mass by the Clock system th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21d98766a81b92945e49b1508d4d8d6
https://doi.org/10.1002/jbmr.3053
https://doi.org/10.1002/jbmr.3053