Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kakaly Ghosh"'
Autor:
Yi Bao, Gokce Oguz, Wee Chyan Lee, Puay Leng Lee, Kakaly Ghosh, Jiayao Li, Panpan Wang, Peter E. Lobie, Sidse Ehmsen, Henrik J. Ditzel, Andrea Wong, Ern Yu Tan, Soo Chin Lee, Qiang Yu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Resistance to anti-HER2 therapies in breast cancer remains a significant clinical challenge. Here, the authors demonstrate that EZH2 regulates response to HER2-targeting therapies in breast cancer, in part, by modulating the expression of PPP2R2B.
Externí odkaz:
https://doaj.org/article/d3c09063233a46f7b4d0dbd7cf8055f0
Autor:
Steven O'Reilly, Kakaly Ghosh, Bhairav Paleja, Andrea Low Hsiu Ling, Nevin Zhihao, Anissa A. Widjaja, Sivakumar Viswanathan, Sebastian Schafer, Eleonora Adami, Benjamin Ng, Pei Min Lio, Benjamin L. George, Umut Altunoglu, Jessie Tan, Stuart A. Cook, Salvatore Albani, Sonia Chothani, Bruno Reversade
Publikováno v:
Rheumatology
Rheumatology (Oxford, England)
Rheumatology (Oxford, England)
Objectives: interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with activation of human dermal fibroblasts (HDFs) from patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7833e40a14eeb4a6d498b16f0981b2c5
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9360
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9360
Autor:
Bruno Reversade, Puck Wee Chan, Naveenan Navaratnam, Hülya Kayserili, Alvin Yu Jin Ng, Thong Teck Tan, Oz Pomp, Carine Bonnard, Rishita Changede, Byrappa Venkatesh, David Carling, Sumanty Tohari, Kakaly Ghosh, Umut Altunoglu
Publikováno v:
Journal of experimental medicine, 217(12):e20191561. Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
A germline homozygous loss-of-function mutation in NUAK2 causes human fetal death due to anencephaly. Our functional tests establish that NUAK2, operating on the Hippo signaling axis, is an essential kinase that regulates cytoskeletal processes that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf55835f168b5f1f3c475ce7d430f86a
http://www.scopus.com/inward/record.url?scp=85089994511&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85089994511&partnerID=8YFLogxK
Autor:
A O Frois, Kanda Sangthongpitag, Vishal Pendharkar, Esther Hq Ong, Enrico Petretto, David M. Virshup, Nathan Harmston, Babita Madan, Jenefer Alam, I H Virshup, Thomas H. Keller, Duraiswamy Athisayamani Jeyaraj, Kakaly Ghosh, Jeffrey Hill, Zhiyuan Ke, Alex Matter, May Ann Lee, Soo Yei Ho, Vithya Manoharan
Publikováno v:
Oncogene
Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part by mutations regulating the abundance of their receptors. Whether these mutations identify a clinical opportunity is an important question. Inhibition of Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72602c084261426c44771fd994ae8f4e
Autor:
Dmitry V. Bulavin, Bryan C Tan, Kamini Kunasegaran, Victor Ho, Gerard A. Tarulli, Alexandra M Pietersen, Kakaly Ghosh, Duvini De Silva
Publikováno v:
Breast Cancer Research : BCR
Introduction The molecular circuitry of different cell types dictates their normal function as well as their response to oncogene activation. For instance, mice lacking the Wip1 phosphatase (also known as PPM1D; protein phosphatase magnesium-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8117e699df06a108cadd8db319c941ae
https://doi.org/10.1186/bcr3381
https://doi.org/10.1186/bcr3381
Autor:
Li Jun Ding, Kanda Sangthongpitag, Kakaly Ghosh, May Ann Lee, Sifang Wang, Babita Madan, Yun Shan Chew, Thomas H. Keller, Shermaine Q.y. Lim, Jeffrey Hill, Zhiyuan Ke, Duraiswamy Athisayamani Jeyaraj, David M. Virshup, Jenefer Alam, Vishal Pendharkar, Vithya Monoharan, Soo Yei Ho, Esther H. Q. Ong
Publikováno v:
Cancer Research. 75:4449-4449
Various mutations in the Wnt pathway contribute to aberrant activation of Wnt signaling, which is implicated in multiple cancers. Besides the mutation of Adenomatous polyposis coli (APC) or beta-catenin which causes the continuous activation of Wnt s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0987ef4557fcda0be1c4167f74fb4aa
https://doi.org/10.1158/1538-7445.am2015-4449
https://doi.org/10.1158/1538-7445.am2015-4449
Autor:
Jenefer Alam, Duraiswamy Athisayamani Jeyaraj, Thomas H. Keller, Li Jun Ding, Jamal Aliyev, Sifang Wang, Kanda Sangthongpitag, Kakaly Ghosh, Yun Shan Chew, Babita Madan, May Ann Lee, Zhiyuan Ke, Soo Yei Ho, Vishal Pendharkar, Shermaine Q.y. Lim, David M. Virshup
Publikováno v:
Molecular Cancer Therapeutics. 12:C248-C248
Dysregulation of the Wnt signaling cascades is implicated in multiple disorders. There are 19 human Wnts that mediate signaling through diverse downstream pathways. To achieve maximum benefit from inhibition of Wnt signaling, targeting all of these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fae1c3c84edb8d3b16105b29bf4e543
https://doi.org/10.1158/1535-7163.targ-13-c248
https://doi.org/10.1158/1535-7163.targ-13-c248